广州医药 ›› 2019, Vol. 50 ›› Issue (2): 44-46.DOI: 10.3969/j.issn.1000-8535.2019.02.011

• 论著 • 上一篇    下一篇

输尿管镜下钬激光碎石术治疗输尿管结石疗效及对氧化应激指标的影响

谢斌   

  1. 廉江市人民医院(廉江 524400)
  • 收稿日期:2018-11-17 出版日期:2019-03-20 发布日期:2021-12-17

The efficacy of ureteroscopic holmium laser lithotripsy in the treatment of ureteral calculi and its effect on oxidative stress

XIE Bin   

  1. Lianjiang People's Hospital, Lianjiang 524400, China
  • Received:2018-11-17 Online:2019-03-20 Published:2021-12-17

摘要: 目的 研究输尿管镜下钬激光碎石术治疗输尿管结石疗效及对氧化应激指标的影响。方法 选取我院2016年3月—2017年4月间收治的输尿管结石患者60例,随机将其分为对照组和观察组,每组各30例。观察组接受输尿管钬激光碎石术治疗,对照组接受传统开放手术治疗。比较两组手术前后白细胞介素-10(IL-10)、C反应蛋白(CRP)、白细胞(WBC)等炎性因子以及皮质醇(Cor)、丙二醛(MDA)、超氧化物歧化酶(SOD)等氧化应激指标水平,同时比较两组碎石情况。结果 观察组手术时间、住院天数低于对照组,结石排净率高于对照组(P<0.05);术后,观察组IL-10、CRP、WBC高于对照组(P<0.05);观察组Cor、MDA低于对照组,而SOD高于对照组(P<0.05)。结论 输尿管镜下钬激光碎石术治疗输尿管结石疗效显著,能够抑制炎性因子,减轻应激反应,促进患者疾病康复,值得临床推广。

关键词: 输尿管镜, 钬激光碎石术, 输尿管结石, 应激反应

Abstract: Objective To study the effect of ureteroscopic holmium laser lithotripsy in the treatment of ureteral calculi and its effect on oxidative stress. Methods Sixty patients with ureteral calculi admitted to our hospital from March 2016 to April 2017 were randomly divided into control group and observation group, with 30 cases in each group. The observation group received ureteroscopic holmium laser lithotripsy and the control group received conventional open surgery. We compared inflammatory factors such as interleukin-10 (IL-10), C-reactive protein (CRP), and white blood cells (WBC) before and after surgery, as well as cortisol (Cor), malondialdehyde (MDA), and superoxide dismutase (SOD) and other levels of oxidative stress indicators, while comparing the two groups of debris. Results The operation time and hospitalization days in the observation group were lower than those in the control group. The stone removal rate was higher than that in the control group (P<0.05). After operation, the IL-10, CRP and WBC in the observation group were higher than those in the control group (P< 0.05). Cor and MDA in the observation group were lower than the control group, and SOD was higher than the control group (P<0.05). Conclusion Ureteroscopic holmium laser lithotripsy is effective in the treatment of ureteral calculi. It can inhibit inflammatory factors, reduce stress response, and promote the recovery of patients' diseases. It is worthy of clinical promotion.

Key words: Ureteroscopy, Holmium laser lithotripsy, Ureteral calculi, Stress response