广州医药 ›› 2018, Vol. 49 ›› Issue (3): 55-58.DOI: 10.3969/j.issn.1000-8535.2018.03.015

• 论著 • 上一篇    下一篇

2011—2016年铜绿假单胞菌耐药性变迁分析

赵祝香1, 周泉1, 陈惠玲1, 王轲1, 李裕军1, 胡国平2   

  1. 1 广州医科大学附属市一人民医院( 广州 510180)
    2 广州医科大学附属第三医院(广州 510150)
  • 收稿日期:2017-12-18 出版日期:2018-05-20 发布日期:2021-12-01
  • 通讯作者: 胡国平,E-mail:hgpgz@126.com

The changes of drug resistance of Pseudomonas aeruginosa from 2011 to 2016

ZHAO Zhuxiang1, ZHOU Quan1, CHEN Huiling1, WANG Ke1, LI Yujun1, HU Guoping2   

  1. 1 Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China
    2 The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150, China
  • Received:2017-12-18 Online:2018-05-20 Published:2021-12-01

摘要: 目的 分析2011—2016年间铜绿假单胞菌分离株的耐药性及变迁情况, 为临床合理用药提供科学依据。方法 对2011年1月—2016年12月广州市第一人民院患者各类标本中分离到的铜绿假单胞菌2 257株进行细菌鉴定及药敏试验,并对耐药性变迁进行统计分析。结果 铜绿假单胞菌在痰液标本中的检出率最高为56.9%;6年铜绿假单胞菌平均耐药率以妥布霉素最低,为9.9%,对哌拉西林/他唑巴坦、头孢吡肟、头孢他啶、左氧氟沙星、环丙沙星、亚胺培南、庆大霉素等药物的耐药率均<20%,在2013年耐药率最低,此后三年逐年上升。结论 铜绿假单胞菌对广州市第一人民院常用抗生素的耐药率在近3年呈逐年上升趋势, 临床医师应根据药敏结果合理选择抗菌药物, 以提高疗效和减缓耐药菌的产生。

关键词: 铜绿假单胞菌, 抗菌药物, 耐药性

Abstract: Objective To analyze the changes of drug resistance of Pseudomonas aeruginosa (Pae) and to provide basis for the use of antibiotics in clinic. Methods 2 257 strains of Pae were cultured and isolated in the First People Hospitalof Guangzhou from 2011 to 2016, API bacterial identification system was applied to carry out bacterial identification and K-B method was used for drug sensitivity analysis. Results Most of the Pae (56.9%) were detected from the sputum specimen. It showed the highest sensitivity to tobramycin. The drug resistance of Pae to piperacillin/tazobactam, cefepime, ceftazidime, levofloxacin, ciprofloxacin, imipenem and gentamicin in 2013 was the lowest and has been increasing year by year. Conclusion Pseudomonas aeruginosa isolated in our hospital showed a rising trend of clinical drug resistance in the past three years. It was of the top priority for clinicians to use antibiotics rationally to retard the production of drug resistant strains.

Key words: Pseudomonas aeruginosa, Antibiotics, Drug resistance