呼气丙酮用于糖尿病肾病患者早期诊断的探讨

doi:10.3969/j.issn.1000-8535.2017.03.006

广州医药 ›› 2017, Vol. 48 ›› Issue (3): 26-28.DOI: 10.3969/j.issn.1000-8535.2017.03.006

呼气丙酮用于糖尿病肾病患者早期诊断的探讨

臧宁, 黄燕文, 岑美婷, 臧诗蕾

广州市第一人民医院南沙医院检验科(广州 511457)

收稿日期:2017-01-21 发布日期:2021-12-01
通讯作者: 臧宁,E-mail:305153437@qq.com
基金资助:
广州市医药卫生科技一般引导项目西医类(20151A010014)

Exhaled acetone is beneficial to early diagnosis of diabetic nephropathy

ZANG Ning, HUANG Yanwen, CEN Meiting, ZANG Shilei

Nansha Hospital of Guangzhou First People's Hospital,Guangzhou 511457,China

Received:2017-01-21 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨呼出气体中丙酮能否用于糖尿病肾病的早期诊断。方法对健康对照组、2型糖尿病组(T2MD)和糖尿病肾病组(DN)分别采用气相色谱-质谱(GC-MS)法测定呼气丙酮含量、全自动生化仪的乳胶透射免疫比浊法测定尿微量白蛋白、酶速率法测试β-羟丁酸以及全自动尿液分析仪干化学法测定尿酮体,并对上述结果进行分析。结果在T2MD组和DN组中呼气中的丙酮含量均高于健康对照组(P<0.01);在DN组,丙酮与尿微量白蛋白水平呈线性相关(r=0.79,P<0.05)。结论检测呼气中的丙酮有助于糖尿病肾病的早期诊断,能及时反映病人肾脏损伤情况。

关键词: 呼气丙酮, 糖尿病肾病, 气相色谱-质谱, 尿微量白蛋白

Abstract: Objective To explore the early diagnosis of diabetic nephropathy by exhaled acetone. Methods Respectively using GC-MS method for the determination of exhaled acetone content, emulsion transmission turbidimetric immunoassay method in automatic biochemical analyzer for determination of urinary microalbumin, enzyme rate method for testing β-hydroxybutyric acidand and dry chemical method in urine automatic analyzer for determination of urine ketone on healthy control group, type-2 diabetes mellitus group(T2MD), and diabetic nephropathy group(DN), and the above results were analyzed. Results The exhale acetone level in T2MD and DN groups were higher than those in control group(P<0.01); In DN group, the level of exhale acetone with urinary microalbumin had a linear correlation. Conclusion The detection of exhale acetone is helpful to early diagnosis in diabetic nephropathy, also may reflect the renal injury promptly.

Key words: Exhaled acetone, Diabetic nephropathy, GC-MS, Urinary microalbumin

臧宁, 黄燕文, 岑美婷, 臧诗蕾. 呼气丙酮用于糖尿病肾病患者早期诊断的探讨[J]. 广州医药, 2017, 48(3): 26-28.

ZANG Ning, HUANG Yanwen, CEN Meiting, ZANG Shilei. Exhaled acetone is beneficial to early diagnosis of diabetic nephropathy[J]. Guangzhou Medical Journal, 2017, 48(3): 26-28.

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呼气丙酮用于糖尿病肾病患者早期诊断的探讨

Exhaled acetone is beneficial to early diagnosis of diabetic nephropathy

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