NLR、PLR、MLR与冠状动脉疾病严重程度的相关性分析

doi:10.3969/j.issn.1000-8535.2023.11.005

摘要/Abstract

摘要： 目的探讨接受冠状动脉造影患者的中性粒细胞-淋巴细胞比值（NLR）、血小板-淋巴细胞比值（PLR）和单核细胞-淋巴细胞比值（MLR）与冠状动脉疾病（CAD）严重程度的关系。方法收集2021年1月—2021年12月在六安市人民医院接受冠状动脉造影的150例急性冠脉综合征（ACS）患者。CAD的严重程度通过Gensini评分进行评估,150例ACS患者根据评分被分为轻度病变组（≤14分,41例）、中度病变组（15~47分,69例）和重度病变组（≥48分,40例）。比较3组的临床指标,采用相关统计学分析NLR、PLR、MLR与CAD严重性（Gensini评分）的相关性。结果纳入研究的150例患者的平均年龄为（66.49±11.43）岁,男性占67.3%。在重度病变组,NLR和PLR值高于其他两组。在Pearson相关性检验中,Gensini评分与NLR呈正相关（r=0.319,P<0.001）,然而,Gensini评分与MLR、PLR之间无相关性（P>0.05）。在Logistic回归分析中,NLR（OR：1.306,95%CI：0.107~0.427）是CAD的独立危险因素。在ROC曲线分析中,发现NLR的曲线下面积最高,为0.723（95%CI：0.629~0.817,P<0.001）,NLR≥0.25为识别CAD存在的最佳临界值,灵敏度为78.49%,特异度为60.26%。结论根据Gensini评分,NLR与CAD的严重程度呈正相关,而研究中未观察到MLR、PLR与CAD严重程度之间的关联。

关键词: 急性冠脉综合征, 中性粒细胞-淋巴细胞比值（NLR）, 血小板-淋巴细胞比值（PLR）, 单核细胞-淋巴细胞比值（MLR）, Gensini评分

Abstract: Objective To explore the correlation of neutrophil-to-lymphocyte ratio（NLR）,platelet-to-lymphocyte ratio（PLR）,monocyte-to-lymphocyte ratio（MLR）with coronary artery disease（CAD）severity in patients undergoing coronary angiography．Methods A total of 150 patients with acute coronary syndrome（ACS）who underwent coronary angiography in Lu'an People's Hospital from January 2021 to December 2021 were enrolled．The severity of CAD was assessed by Gensini score,according to the score,150 patients with ACS were divided into mild disease group（≤14 points,41 cases）,moderate disease group（15-47 points,69 cases）and severe disease group（≥48 points,40 cases）．Clinical indicators of the three groups were compared,and related statistics were used to analyze the correlation between NLR,PLR,MLR and the severity of coronary artery lesions（Gensini score）．Results The average age of selected 150 patients was（66.49±11.43）,67.3% were male．In the severe disease group,NLR,PLR values were higher than the other two groups．A positive significant correlation was found between Gensini score and NLR（r=0.319,P<0.001）by Pearson's correlation test．However,no correlation was found between Gensini score and MLR and PLR（P>0.05）．In the Logistic regression analysis,NLR（OR：1.306,95% CI：0.107-0.427）was the independent risk factor of CAD．In receiver operating characteristic curve analysis,NLR was found to have highest area under the curve at 0.723（95% CI：0.629-0.817,P<0.001）,with an optimal cut-off value of 0.25,predicting the severe coronary lesion with a sensitivity of 60.26% and specificity of 78.49%．Conclusions The NLR is positively correlated with the severity of CAD．No correlation between MLR,PLR and severity of CAD in the cohort were observed．

Key words: acute coronary syndrome, NLR, PLR, MLR, Gensini score

罗寒玉, 冯俊, 曹瑞, 王本龙. NLR、PLR、MLR与冠状动脉疾病严重程度的相关性分析[J]. 广州医药, 2023, 54(11): 30-35.

LUO Hanyu, FENG Jun, CAO Rui, WANG Benlong. The correlation of NLR,PLR and MLR with coronary artery disease severity[J]. Guangzhou Medical Journal, 2023, 54(11): 30-35.

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