广州医药 ›› 2023, Vol. 54 ›› Issue (8): 17-21.DOI: 10.3969/j.issn.1000-8535.2023.08.003

• 论著 • 上一篇    下一篇

河源市源城区2 468例儿童呼吸道感染病原体核酸检测结果分析

陈运恒, 邱莉, 廖翠芳, 骆红   

  1. 广东省河源市妇幼保健院(河源 517000)
  • 收稿日期:2022-11-13 出版日期:2023-08-20 发布日期:2023-09-13

Analysis of nucleic acid detection results of respiratory tract infection pathogens in 2 468 children in Yuancheng District of Heyuan City

CHEN Yunheng, QIU Li, LIAO Cuifang, LUO Hong   

  1. Heyuan Maternal and Child Health Hospital,Heyuan 517000,China
  • Received:2022-11-13 Online:2023-08-20 Published:2023-09-13

摘要: 目的 分析不同年龄、不同季节河源市源城区呼吸道感染的病原学情况,指导临床用药。方法 回顾性研究2020年3月—2022年2月2 468例呼吸道感染的住院患儿,取咽部分泌物送广州达安临床检验中心进行呼吸道核酸六项检测并分析结果。包括:肺炎链球菌(Sp)、呼吸道合胞病毒(RSV)、卡他莫拉菌(MC)、流感嗜血杆菌(Hi)、肺炎支原体(LP)、腺病毒(ADV)。结果 (1)2 468例患儿的标本中阳性率52.8%,其中RSV最高,其他依次为Sp、Hi、MC、MP、ADV。而混合感染仅次于RSV。(2)婴儿组和幼儿组以RSV感染为主,在学龄前组和学龄组儿童中,以Sp感染为主,各病原体的混合感染组合很多,一种细菌合并一种病毒多见。(3)秋冬季是河源市源城区呼吸道感染的高发季节,RSV是秋冬季呼吸道感染最主要的病原体。结论 秋冬季节为河源市源城区呼吸道感染的高发季节,RSV为该季节的主要病原体。RSV也是婴幼儿组感染的主要致病菌,随着年龄增大,细菌感染导致的呼吸道疾病逐渐占优势。混合感染在各年龄组中均占比较高,值得临床诊疗的重视。

关键词: 儿童, 源城区, 呼吸道感染, 呼吸道核酸检测, 病原体

Abstract: Objective To analyze the etiology of respiratory tract infection in Yuancheng District of Heyuan City ,which was in different ages and seasons,and to provide guidance of clinical drug usage.Methods Cases of 2 468 hospitalized children with respiratory tract infection from March 2020 to February 2022 were analyzed.The secretion from pharynx was collected and sent to Guangzhou Da’an Clinical Examination Center for six respiratory nucleic acid tests and then the results were analyzed,including Streptococcus pneumoniae(Sp),respiratory syncytial virus(RSV),Moraxella catarrhalis(MC),Haemophilus influenzae(Hi),Mycoplasma pneumonia(MP),adenovirus(ADV).Results The positive rate of 2 468 hospitalized children with respiratory tract infection was 52.8%,of which the highest was RSV,followed by Sp,Hi,MC,MP,ADV.Meanwhile the mixed infection rate was second to RSV.RSV infection was the main infection in infant group and early-aged children group,while in preschool group and school-aged group,Sp infection was the main infection.There were many mixed infection of pathogen,and one bacteria combined with one virus was more common.Respiratory tract infection had high incidence in autumn and winter in Yuancheng District of Heyuan City,RSV was the major pathogen.Conclusions Autumn and winter were the seasons with high respiratory tract infection incidence in Yuancheng District of Heyuan City,and RSV was the main pathogen in these two seasons.RSV was also the main pathogen of infant group infection.But with the increase of children’s age,bacterial infection became the main reason of respiratory tract diseases.Mixed infection accounts for a high proportion in all age groups,which should be valued in clinical diagnosis and treatment.

Key words: children, Yuancheng District, respiratory tract infection, respiratory nucleic acid detection, pathogen