尿液PSA预测老年良性前列腺增生发生急性尿潴留的临床研究

doi:10.3969/j.issn.1000-8535.2023.04.003

广州医药 ›› 2023, Vol. 54 ›› Issue (4): 21-24.DOI: 10.3969/j.issn.1000-8535.2023.04.003

尿液PSA预测老年良性前列腺增生发生急性尿潴留的临床研究

陈见辉¹, 冯奕习¹, 李汉秋¹, 陈凯妮², 黄雪梅¹, 吕慧贤¹

1 东莞市中医院（东莞 523000）;
2 东莞市大朗医院（东莞 523000）

收稿日期:2022-07-08 出版日期:2023-04-20 发布日期:2023-05-18
通讯作者: 冯奕习,E-mail：dkft280@163.com
基金资助:
广东省医学科研基金（C2022126）

Clinical study of urinary PSA in predicting acute urinary retention in elderly patients with benign prostatic hyperplasia

CHEN Jianhui¹, FENG Yixi¹, LI Hanqiu¹, CHEN Kaini², HUANG Xuemei¹, LV Huixian¹

1 Dongguan Hospital of Traditional Chinese Medicine,Dongguan 523000,China;
2 Dongguan Dalang Hospital,Dongguan 523000,China

Received:2022-07-08 Online:2023-04-20 Published:2023-05-18

摘要/Abstract

摘要： 目的探讨尿液前列腺特异性抗原（u-PSA）预测老年良性前列腺增生（BPH）发生急性尿潴留（AUR）的价值。方法选取东莞市中医院100例老年BPH患者（2020年1月—2021年4月）进行回顾性研究,均口服盐酸坦索罗辛+非那雄胺片治疗,随访1年,记录AUR发生情况,据此分为AUR组、非AUR组。比较2组一般资料,Logistic回归模型分析老年BPH发生AUR的危险因素,受试者工作特征（ROC）分析前列腺体积（PV）、u-PSA对老年BPH发生AUR的预测价值。结果 100例老年BPH患者AUR发生率为26%;AUR组u-PSA水平高于非AUR组,PV大于非AUR组（P<0.05）;Logistic回归模型分析,u-PSA水平及PV增高是老年BPH患者发生AUR的独立危险因素（P<0.05）;ROC曲线分析,u-PSA预测AUR的AUC=0.897,高于AUC_PV（P<0.05）。结论 u-PSA可作为老年BPH继发AUR的量化评估指标,有利于临床早期筛查、诊断,采取针对性干预措施,改善预后。

关键词: 前列腺特异性抗原, 急性尿潴留, 良性前列腺增生, 预测价值

Abstract: Objective To investigate the value of urinary prostate-specific antigen（u-PSA）in predicting acute urinary retention（AUR）in elderly patients with benign prostatic hyperplasia（BPH）．Methods A total of 100 elderly patients with BPH in our hospital（from January 2020 to April 2021）were selected for a retrospective study,all of whom were treated with oral tamsulosin hydrochloride + finasteride tablets,followed up for 1 year,and the occurrence of AUR was recorded．The patients were divided into AUR group and non-AUR group．The general data of the two groups were compared．Logistic regression model was used to analyze the risk factors of AUR in elderly BPH patients,and receiver operating characteristic（ROC）was used to analyze the predictive value of prostate volume（PV）and u-PSA for AUR occurrence．Results The incidence of AUR in 100 elderly patients with BPH was 26%;the level of u-PSA in the AUR group was higher than that in the non-AUR group,and the PV was greater than that in the non-AUR group（P<0.05）．Increased PV was an independent risk factor for AUR in elderly patients with BPH（P<0.05）．ROC curve analysis showed that the AUC of u-PSA for predicting AUR was 0.897,which was higher than that of PV（P<0.05）．Conclusions u-PSA can be used as a quantitative evaluation index for AUR secondary to BPH in the elderly,which is conducive to early clinical screening and diagnosing,and taking targeted intervention measures to improve prognosis.

Key words: prostate specific antigen, acute urinary retention, benign prostatic hyperplasia, predictive value

陈见辉, 冯奕习, 李汉秋, 陈凯妮, 黄雪梅, 吕慧贤. 尿液PSA预测老年良性前列腺增生发生急性尿潴留的临床研究[J]. 广州医药, 2023, 54(4): 21-24.

CHEN Jianhui, FENG Yixi, LI Hanqiu, CHEN Kaini, HUANG Xuemei, LV Huixian. Clinical study of urinary PSA in predicting acute urinary retention in elderly patients with benign prostatic hyperplasia[J]. Guangzhou Medical Journal, 2023, 54(4): 21-24.

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尿液PSA预测老年良性前列腺增生发生急性尿潴留的临床研究

Clinical study of urinary PSA in predicting acute urinary retention in elderly patients with benign prostatic hyperplasia

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