环状RNA与环境相关疾病

doi:10.3969/j.issn.1000-8535.2023.03.001

广州医药 ›› 2023, Vol. 54 ›› Issue (3): 1-7.DOI: 10.3969/j.issn.1000-8535.2023.03.001

• 专家综述 • 下一篇

环状RNA与环境相关疾病

李美珍, 蒋义国

广州医科大学化学致癌研究所,呼吸疾病国家重点实验室(广州 511436)

收稿日期:2022-12-10 出版日期:2023-03-20 发布日期:2023-04-14
通讯作者: 蒋义国,E-mial: jiangyiguo@vip.163.com
作者简介:蒋义国,二级教授,广州医科大学学术委员会主任委员、公共卫生学院院长、化学致癌研究所所长、呼吸疾病国家重点实验室课题组长。国家百千万人才工程入选专家,享受国务院政府特殊津贴。国际权威杂志Toxicological Sciences副主编,《广州医药》杂志副主编,全国研究生规划教材《分子毒理学》主编,创建了中国毒理学会表观遗传毒理专业委员会,任主任委员,荣获中国毒理学杰出贡献奖。主要从事肿瘤病因、分子毒理学研究,主持国家自然科学基金重点项目2项、面上项目8项。近年在表观遗传学,特别是非编码RNA研究上进行了许多创新性工作,以通讯作者发表高水平论文50余篇。以第一完成人获国家教育部科技成果自然科学二等奖1项,广东省科技成果自然科学二等奖2项。
基金资助:
国家自然科学基金重点项目(82130095),国家自然科学基金重大研究计划重点支持项目(91643204)

Circular RNA and environmental related diseases

LI Meizhen, JIANG Yiguo

Institute for Chemical Carcinogenesis of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou 511436, China

Received:2022-12-10 Online:2023-03-20 Published:2023-04-14

摘要/Abstract

摘要： 人类疾病的发生发展是环境因素与遗传学因素相互作用的结果。环境有害暴露导致的机体功能紊乱和疾病发生,与细胞内环状RNA(circRNA)的表达异常有密切关系,circRNA的功能和作用是医学研究的热点领域。circRNA是表观遗传学的一类具有环状结构的RNA分子,由于其特殊的结构和复杂的功能,在调控疾病发生和病理过程中承担着重要角色。本文系统地介绍了circRNA的来源、功能,结合作者课题组的研究成就,综述了circRNA在环境有害暴露相关疾病中的作用和机制,探讨了circRNA作为潜在生物标志物在研究中所面临的挑战。

关键词: circRNA, 表观遗传学, 环境化学物, 生物标志物

Abstract: The development of human diseases is the result of the interaction between environmental and genetic factor. Abnormal expression of cellular circular RNA (circRNA) is closely related to function disorders and diseases caused by environmental exposure. The function of circRNA is a research focus in medical science. CircRNA is the epigenetic molecular with circular structure. Because of its special structure and complex function, it plays an important role in the regulation of disease occurrence and pathological process. In this paper, the origin and functions of circRNA are systematically described. Combined with the achievements of the author's research group, the functions and mechanism of environmental exposure related diseases were reviewed. And the challenges of circRNA as a potential biomarker in research were discussed.

Key words: circRNA, epigenetics, environmental chemicals, biomarker

李美珍, 蒋义国. 环状RNA与环境相关疾病[J]. 广州医药, 2023, 54(3): 1-7.

LI Meizhen, JIANG Yiguo. Circular RNA and environmental related diseases[J]. Guangzhou Medical Journal, 2023, 54(3): 1-7.

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环状RNA与环境相关疾病

Circular RNA and environmental related diseases

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