FtsZ抑制剂作为新型抗菌分子的研究进展

doi:10.3969/j.issn.1000-8535.2023.02.002

广州医药 ›› 2023, Vol. 54 ›› Issue (2): 9-17.DOI: 10.3969/j.issn.1000-8535.2023.02.002

FtsZ抑制剂作为新型抗菌分子的研究进展

郭琦¹, 郭泽莉¹, 吴文玉¹, 孙宁²

1 中山大学中山眼科中心,眼科学国家重点实验室,广东省眼科视觉科学重点实验室(广州 510060)
2 广州市第一人民医院/华南理工大学附属第二医院(广州 510180)

收稿日期:2022-12-01 出版日期:2023-02-20 发布日期:2023-02-27
通讯作者: 郭琦,现就职于中山大学中山眼科中心药学部,从事药事管理、临床药学及眼科临床药物试验管理工作。2011年毕业于中山大学药学院。参与发表学术论文6篇,参与完成国家自然科学基金、广东省自然科学基金各一项。参与编撰人民卫生出版社出版《五官科疾病》一书。现任广东省药学会眼科药学专家委员会委员。E-mail: 348363178@qq.com;孙宁,广州市第一人民医院临床医学研究所副教授/副研究员。曾任香港理工大学化学生物学与药物研发国家重点实验室Research Fellow、美国亚利桑那大学药理毒理系访问学者、广州医科大学“南山学者”特聘副教授。现任《广州医药》、Frontiers in Microbiology等期刊的编委或客座编委;Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry、Antibiotics等期刊的特邀审稿人。主要研究方向为抗菌新靶点的发现及抗菌分子的机制研究。E-mail: ning.sun@connect.polyu.hk
基金资助:
国家自然科学基金(81703333)

Recent advances of FtsZ inhibitors as new antibacterial agents

GUO Qi¹, GUO Zeli¹, WU Wenyu¹, SUN Ning²

1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060,China
2 Guangzhou First People's Hospital, Second Affiliated Hospital of South China University of Technology, Guangzhou 510180, China

Received:2022-12-01 Online:2023-02-20 Published:2023-02-27

摘要/Abstract

摘要： 近年来,由于抗生素的不合理使用,导致新型耐药性细菌不断出现,严重危害人类健康,迫使我们急需发现新型抗菌药物来对抗耐药性细菌引起的感染。FtsZ蛋白是细菌分裂的必需蛋白,在细菌分裂增殖过程中起着关键作用。当FtsZ的功能受到抑制时,细菌的分裂增殖亦会被抑制,最终导致细菌死亡。FtsZ蛋白是目前热门的抗菌新靶点之一。本文回顾了FtsZ蛋白的生物学功能,总结了以FtsZ为靶标的新型抗菌分子的研究进展。

关键词: 耐药性细菌, 细菌分裂蛋白FtsZ, FtsZ抑制剂

Abstract: Antibiotic-resistant bacterial infection has become epidemic all over the world. To overcome the drug resistance problem, antibacterial agents targeting at new binding sites become critical. FtsZ, a bacterial cell division protein, has become a new attractive target for antibacterial agents’ discovery because it is the most important and conserved protein in bacterial cell division. Cell division will be inhibited when the functions of FtsZ were disturbed. In this article, the biological functions of FtsZ have been reviewed, and recent advances in discovery of FtsZ inhibitors were summarized.

Key words: drug-resistant bacteria, cell division protein FtsZ, FtsZ inhibitors

郭琦, 郭泽莉, 吴文玉, 孙宁. FtsZ抑制剂作为新型抗菌分子的研究进展[J]. 广州医药, 2023, 54(2): 9-17.

GUO Qi, GUO Zeli, WU Wenyu, SUN Ning. Recent advances of FtsZ inhibitors as new antibacterial agents[J]. Guangzhou Medical Journal, 2023, 54(2): 9-17.

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FtsZ抑制剂作为新型抗菌分子的研究进展

Recent advances of FtsZ inhibitors as new antibacterial agents

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