声学调控实体肿瘤理化微环境的机制与研究进展

doi:10.3969/j.issn.1000-8535.2022.06.002

广州医药 ›› 2022, Vol. 53 ›› Issue (6): 7-13.DOI: 10.3969/j.issn.1000-8535.2022.06.002

声学调控实体肿瘤理化微环境的机制与研究进展

冯玉仪, 柳建华

华南理工大学附属第二医院,广州市第一人民医院超声医学科(广州 510180)

收稿日期:2022-08-23 出版日期:2022-11-20 发布日期:2022-11-30
通讯作者: 柳建华,E-mail:eyliujianhua@scut.edu.cn
作者简介:柳建华,医学博士,华南理工大学附属第二医院(广州市第一人民医院)超声医学科主任、教授、主任医师,博士研究生导师。
从事超声医学工作30余年,擅长腹部和浅表器官超声诊断和介入治疗,获省部级科技进步奖3项,主持国家自然科学基金面上项目1项、863计划子课题1项、省市课题10余项,以第一作者或通信作者发表论文160余篇,主编或参编专著10余部。学术任职:中国医学影像技术研究会超声分会腹部专委会常委、亚太卫生健康协会超声分会副主席、广东省医学会超声分会副主委、广东省超声医学工程学会副会长、广州市医师协会超声医师分会主委、《广州医药》杂志编委等。
基金资助:
国家自然科学基金(82071935)

Received:2022-08-23 Online:2022-11-20 Published:2022-11-30

摘要/Abstract

摘要： 实体肿瘤物理和化学微环境异常阻碍了肿瘤与外界进行物质交换,降低了药物渗入肿瘤组织,是肿瘤对放化疗抵抗的重要原因。目前,已有多种针对肿瘤微环境各个组分的治疗方法,如使血管正常化、降低肿瘤间质液压、降解细胞外基质等,以达到增强药物等的渗出,从而增强肿瘤治疗效果。声学调控是改变肿瘤理化微环境的一种有效方法,本文对声学调控其中几个主要的机制和研究进展进行综述,以期为临床肿瘤治疗提供新思路。

关键词: 声学调控, 肿瘤微环境, 结构, 理化特性

冯玉仪, 柳建华. 声学调控实体肿瘤理化微环境的机制与研究进展[J]. 广州医药, 2022, 53(6): 7-13.

参考文献

[1] WU T,DAI Y.Tumor microenvironment and therapeutic response[J].Cancer Lett,2017(387):61-68.
[2] NIA H T,MUNN L L,JAIN R K.Physical traits of cancer[J].Science,2020,370(6516):eaaz0868.
[3] SPILL F,REYNOLDS D S,KAMM R D,et al.Impact of the physical microenvironment on tumor progression and metastasis[J].Curr Opin Biotechnol,2016(40):41-48.
[4] XIAO N,LIU J,LIAO L,et al.Improved delivery of doxorubicin by altering the tumor microenvironment using ultrasound combined with microbubbles and chemotherapy[J].J BUON,2019,24(2):844-852.
[5] FORSTER J C,HARRISS-PHILLIPS W M,DOUGLASS M J,et al.A review of the development of tumor vasculature and its effects on the tumor microenvironment[J].Hypoxia (Auckl),2017(5):21-32.
[6] SAUTES-FRIDMAN C,PETITPREZ F,CALDERARO J,et al.Tertiary lymphoid structures in the era of cancer immunotherapy[J].Nat Rev Cancer,2019,19(6):307-325.
[7] HELDIN C,RUBIN K,PIETRAS K,et al.High interstitial fluid pressure-an obstacle in cancer therapy[J].Nature Reviews Cancer,2004,4(10):806-813.
[8] GOUARDERES S,MINGOTAUD A F,VICENDO P,et al.Vascular and extracellular matrix remodeling by physical approaches to improve drug delivery at the tumor site[J].Expert Opin Drug Deliv,2020,17(12):1703-1726.
[9] JING X,YANG F,SHAO C,et al.Role of hypoxia in cancer therapy by regulating the tumor microenvironment[J].Mol Cancer,2019,18(1):157.
[10] BROWN J M,WILSON W R. Exploiting tumour hypoxia in cancer treatment[J].Nat Rev Cancer,2004,4(6):437-447.
[11] TREDAN O,GALMARINI C M,PATEL K,et al.Drug resistance and the solid tumor microenvironment[J].J Natl Cancer Inst,2007,99(19):1441-1454.
[12] JAIN R K. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers[J].J Clin Oncol,2013,31(17):2205-2218.
[13] KRISHNA PRIYA S,NAGARE R P,SNEHA V S,et al.Tumour angiogenesis-Origin of blood vessels[J].Int J Cancer,2016,139(4):729-735.
[14] BARLOW K D,SANDERS A M,SOKER S,et al.Pericytes on the tumor vasculature: Jekyll or hyde?[J].Cancer Microenviron,2013,6(1):1-17.
[15] DE PALMA M,BIZIATO D,PETROVA T V. Microenvironmental regulation of tumour angiogenesis[J].Nature Reviews Cancer,2017,17(8):457-474.
[16] WU J. The Enhanced permeability and retention (EPR) effect: The significance of the concept and methods to enhance its application[J].J Pers Med,2021,11(8):771.
[17] MAGNUSSEN A L,MILLS I G. Vascular normalisation as the stepping stone into tumour microenvironment transformation[J].Br J Cancer,2021,125(3):324-336.
[18] DU S,XIONG H,XU C,et al.Attempts to strengthen and simplify the tumor vascular normalization strategy using tumor vessel normalization promoting nanomedicines[J].Biomater Sci,2019,7(3):1147-1160.
[19] LUNT S J,KALLIOMAKI T M,BROWN A,et al.Interstitial fluid pressure,vascularity and metastasis in ectopic,orthotopic and spontaneous tumours[J].BMC Cancer,2008(8):2.
[20] WINSLOW T B,ERANKI A,ULLAS S,et al.A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion,interstitial fluid pressure,hypoxia and efficacy of radiation therapy[J].Int J Hyperthermia,2015,31(6):693-701.
[21] ROSS J P,CAI X,CHIU J,et al.Optical and atomic force microscopic studies on sonoporation[J].J Acoust Soc Am,2002,111(3):1161-1164.
[22] CHEN H,BRAYMAN A A,BAILEY M R,et al.Blood vessel rupture by cavitation[J].Urol Res,2010,38(4):321-326.
[23] WANG T Y,CHOE J W,PU K,et al.Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer[J].J Control Release,2015(203):99-108.
[24] WANG J,ZHAO Z,SHEN S,et al.Selective depletion of tumor neovasculature by microbubble destruction with appropriate ultrasound pressure[J].Int J Cancer,2015,137(10):2478-2491.
[25] GOERTZ D E. An overview of the influence of therapeutic ultrasound exposures on the vasculature: high intensity ultrasound and microbubble-mediated bioeffects[J].Int J Hyperthermia,2015,31(2):134-144.
[26] YANG R,REILLY C R,RESCORLA F J,et al.High-intensity focused ultrasound in the treatment of experimental liver cancer[J].Arch Surg,1991,126(8):1002-1010.
[27] VAN LEENDERS G J,BEERLAGE H P,RUIJTER E T,et al.Histopathological changes associated with high intensity focused ultrasound (HIFU) treatment for localised adenocarcinoma of the prostate[J].J Clin Pathol,2000,53(5):391-394.
[28] GUAN L,XU G. Destructive effect of HIFU on rabbit embedded endometrial carcinoma tissues and their vascularities[J].Oncotarget,2017,8(12):19577-19591.
[29] SON S,KIM J H,WANG X,et al.Multifunctional sonosensitizers in sonodynamic cancer therapy[J].Chem Soc Rev,2020,49(11):3244-3261.
[30] THEOCHARIS A D,SKANDALIS S S,GIALELI C,et al.Extracellular matrix structure[J].Adv Drug Deliv Rev,2016(97):4-27.
[31] NAJAFI M,FARHOOD B,MORTEZAEE K. Extracellular matrix (ECM) stiffness and degradation as cancer drivers[J].J Cell Biochem,2019,120(3):2782-2790.
[32] ZHANG Q,JIN H,CHEN L,et al.Effect of ultrasound combined with microbubble therapy on interstitial fluid pressure and VX2 tumor structure in rabbit[J].Front Pharmacol,2019(10):716.
[33] LI T,WANG Y,KHOKHLOVA T D,et al.Pulsed high-intensity focused ultrasound enhances delivery of doxorubicin in a preclinical model of pancreatic cancer[J].Cancer Res,2015,75(18):3738-3746.
[34] BOHARI S P,GROVER L M,HUKINS D W. Pulsed low-intensity ultrasound increases proliferation and extracelluar matrix production by human dermal fibroblasts in three-dimensional culture[J].J Tissue Eng,2015(6):1013755671.
[35] STYLIANOPOULOS T,MARTIN J D,SNUDERL M,et al.Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse[J].Cancer Res,2013,73(13):3833-3841.
[36] FUKUMURA D,JAIN R K. Tumor microenvironment abnormalities: Causes,consequences,and strategies to normalize[J].J Cell Biochem,2007,101(4):937-949.
[37] TIEN J,DANCE Y W,GHANI U,et al.Interstitial hypertension suppresses escape of human breast tumor cells via convection of interstitial fluid[J].Cell Mol Bioeng,2021,14(2):147-159.
[38] JACOBETZ M A,CHAN D S,NEESSE A,et al.Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer[J].Gut,2012,62(1):112-120.
[39] GOEL S,DUDA D G,XU L,et al.Normalization of the vasculature for treatment of cancer and other diseases[J].Physiol Rev,2011,91(3):1071-1121.
[40] HE Y,YU M,WANG J,et al.Improving the therapeutic effect of ultrasound combined with microbubbles on muscular tumor xenografts with appropriate acoustic pressure[J].Front Pharmacol,2020(11):1057.
[41] XI F,FENG Y,CHEN Q,et al.Microbubbles ultrasonic cavitation regulates tumor interstitial fluid pressure and enhances sonodynamic therapy[J].Front Oncol,2022(12):852454.
[42] MOHAMMADABADI A,HUYNH R N,WADAJKAR A S,et al.Pulsed focused ultrasound lowers interstitial fluid pressure and increases nanoparticle delivery and penetration in head and neck squamous cell carcinoma xenograft tumors[J].Phys Med Biol,2020,65(12):125017.
[43] SASSAROLI E,O'NEILL B E. Modulation of the interstitial fluid pressure by high intensity focused ultrasound as a way to alter local fluid and solute movement: insights from a mathematical model[J].Phys Med Biol,2014,59(22):6775-6795.
[44] MICHIELI P. Hypoxia,angiogenesis and cancer therapy: To breathe or not to breathe?[J].Cell cycle,2009,8(20):3291-3296.
[45] HOLMQUIST L,LOFSTEDT T,PAHLMAN S. Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models[J].Adv Exp Med Biol,2006(587):179-193.
[46] SILKUNAS M,BAVIRSA M,SAULE R,et al.To breathe or not to breathe? Hypoxia after pulsed-electric field treatment reduces the effectiveness of electrochemotherapy in vitro[J].Bioelectrochemistry,2021(137):107636.
[47] OVERGAARD J. Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck--a systematic review and meta-analysis[J].Radiother Oncol,2011,100(1):22-32.
[48] BENNETT M H,FELDMEIER J,SMEE R,et al.Hyperbaric oxygenation for tumour sensitisation to radiotherapy[J].Cochrane Database Syst Rev,2018(4):D5007.
[49] HATFIELD S M,KJAERGAARD J,LUKASHEV D,et al.Immunological mechanisms of the antitumor effects of supplemental oxygenation[J].Sci Transl Med,2015,7(277):230r-277r.
[50] HO Y,CHU S,LIAO E,et al.Normalization of tumor vasculature by oxygen microbubbles with ultrasound[J].Theranostics,2019,9(24):7370-7383.
[51] MCEWAN C,OWEN J,STRIDE E,et al.Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours[J].J Control Release,2015(203):51-56.
[52] 杨希,蒋帅,艾莉莎,等. HIF-1α在不同超声强度联合脂氟显微泡辐照局部化疗肿瘤组织中的表达及意义[J].中国超声医学杂志,2018,34(11):1035-1038.
[53] HOSSEINPOUR M,KHAMECHIAN T,SHAHROKH S. Peritoneal potassium and pH measurement in early diagnosis of acute mesenteric ischemia in rats[J].Arch Trauma Res,2014,3(3):e20957.
[54] KOLTAI T,CARDONE R A,RESHKIN S J. Synergy between low dose metronomic chemotherapy and the pH-centered approach against cancer[J].Int J Mol Sci,2019,20(21):5438.
[55] SETOYAMA T,LING H,NATSUGOE S,et al.Non-coding RNAs for medical practice in oncology[J].Keio J Med,2011,60(4):106-113.
[56] LIANG G,HAN J,XING D. Precise tumor photothermal therapy guided and monitored by magnetic resonance/photoacoustic imaging using a safe and pH-responsive Fe(Ⅲ) complex[J].Adv Healthc Mater,2021,10(3):2001300.
[57] CHEN H,MA A,YIN T,et al.In situ photocatalysis of TiO-porphyrin-encapsulated nanosystem for highly efficient oxidative damage against hypoxic tumors[J].ACS Appl Mater Interfaces,2020,12(11):12573-12583.
[58] 张丽,罗婉贤,杨莉,等. 双配体pH敏感阿霉素前药-微泡复合物制备及体外药物释放研究[J].中华超声影像学杂志,2018,27(4):348-352.

声学调控实体肿瘤理化微环境的机制与研究进展

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