布托啡诺用于剖宫产围术期寒战患者治疗中的有效剂量分析

doi:10.3969/j.issn.1000-8535.2022.01.008

摘要/Abstract

摘要： 目的探讨剖宫产围术期患者采用布托啡诺治疗寒战的最佳剂量。方法选取2019年10月—2020年11月期间于本院分娩的150例剖宫产妇女作为研究对象,按照随机数字表法分为A组、B组、C组,各组50例。A组给予0.01 mg/kg布托啡诺静脉注射,B组给予0.02 mg/kg,C组给予0.03 mg/kg。比较3组临床疗效、血流动力学、镇静(Ramesay)评分、不良反应、新生儿Apgar评分。结果 3组治疗有效率、血流动力学、T₁、T₂时间段Ramesay评分及1 min、5 min、10 min 新生儿Apgar评分比较,差异无统计学意义(P＞0.05);C组不良反应发生率高于B组与A组(P＜0.05);T₃时间段Ramesay评分C组＜B组＜A组(P＜0.05)。结论 0.02 mg/kg剂量布托啡诺治疗剖宫产围术期寒战效果最为理想,产妇围术期血流动力学稳定,不良反应较轻,且对新生儿无明显影响。

关键词: 剖宫产, 布托啡诺, 寒战, 最佳剂量, 不良反应, 血流动力学

Abstract: Objective To investigate the optimal dose of butorphanol in the treatment of shivering in patients underwent cesarean section. Methods A total of 150 women with cesarean section in our hospital from October 2019 to November 2020 were selected as the research objects, and were divided into group A, group B and group C according to random number table method, with 50 cases in each group. Group A was given 0.01 mg/kg butorphanol intravenously, group B was given 0.02 mg/kg, and group C was given 0.03 mg/kg. Clinical efficacy, hemodynamics, sedation (Ramesay) scores, adverse drug reactions (ADR) and neonatal Apgar scores were compared among the three groups. Results There were no significant differences in effective rate, hemodynamics, Ramesay scores at T₁ and T₂ time periods and Apgar scores of neonates at 1 min, 5 min and 10 min among the three groups (P>0.05). The incidence of ADR in group C was higher than that in group B and A (P<0.05). Ramesay score at time of T₃ of group C was lower than group B and group A (P<0.05). Conclusion The 0.02 mg/kg dose of butorphanol in the treatment of perioperative shivering in cesarean section was the most ideal dose, perioperative hemodynamics of puerpera was stable, adverse reactions were mild, and there was no obvious influence on neonates.

Key words: cesarean section, butorphanol, shivering, optimal dose, adverse reactions, hemodynamics

戴中亮, 田迪, 邢燕梅, 陈长友, 林娟, 宋意锋, 田雅, 王萍, 石伟. 布托啡诺用于剖宫产围术期寒战患者治疗中的有效剂量分析[J]. 广州医药, 2022, 53(1): 40-44.

DAI Zhongliang, TIAN Di, XING Yanmei, CHEN Changyou, LIN Juan, SONG Yifeng, TIAN Ya, WANG Ping, SHI Wei. Analysis of effective dose of butorphanol in the treatment of perioperative shivering patients underwent cesarean section[J]. Guangzhou Medical Journal, 2022, 53(1): 40-44.

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