广州医药 ›› 2015, Vol. 46 ›› Issue (6): 44-45.DOI: 10.3969/j.issn.1000-8535.2015.06.014

• 论著 • 上一篇    下一篇

儿童支原体肺炎免疫球蛋白、补体水平及动态变化

梁少媛, 汤少珊, 陈广道   

  1. 广州市番禺区中心医院 儿科(广州 511400)
  • 收稿日期:2015-06-18 发布日期:2021-11-30
  • 通讯作者: 陈广道,E-mail:doctor_cgd79@126.com
  • 基金资助:
    广州市医药卫生科技项目(20131A011191);广州市番禺区科技计划项目(2013-Z03-10)

The changes of serum immunoglobulins and complements in children with mycoplasma pneumoniae pneumonia

Liang Shaoyuan, Tang Shaoshan, Chen Guangdao   

  1. Department of Pediatrics, Central Hospital of Panyu District, Guangzhou 511400, China
  • Received:2015-06-18 Published:2021-11-30

摘要: 目的 比较肺炎支原体肺炎(MPP)、非MPP患儿和健康儿童的免疫球蛋白、补体水平,以探讨儿童MPP体液免疫指标的变化规律。方法 分别检测52例MPP、55例非MPP患儿和33例健康儿童的血清免疫球蛋白(IgG、IgA、IgM)、补体(C3、C4),并比较儿童MPP急性期和恢复早期体液免疫指标。结果 MPP组急性期血清IgM、C3、C4水平高于非MPP组急性期和健康儿童(P<0.05)。儿童MPP恢复早期IgM水平高于急性期,C4水平低于急性期(P<0.05)。结论 与非MPP和健康儿童比较,MPP患儿存在明显体液免疫功能紊乱,从急性期到恢复早期,血清IgM逐渐升高,补体C4先升高后降低,自身免疫反应可能参与了儿童MPP的发病过程。

关键词: 肺炎支原体肺炎, 免疫球蛋白, 补体, 变化, 儿童

Abstract: Objective To investigate the changes of serum immunoglobulins and complement in children with mycoplasma pneumoniae pneumonia (MPP). Methods 52 children with MPP, 55 children with non-MPP and 33 healthy children were enrolled. The levels of serum immunoglobulins (IgG, IgA and IgM) and complements (C3, C4) were detected. Results Compared with the non-MPP group and healthy control, the levels of IgM, C3 and C4 in MPP group during their acute phase were significantly higher (P<0.05). And among the MPP group the levels of IgM were hisher and C4 were lower than that in the acute phase. Conclusion Immune function disturbance exists in children with MPP. From acute to recovery stage, the level of IgM increased while C4 increased firstly and then decreased. Immune injury may be involved in the pathophysiology of childhood MPP.

Key words: Mycoplasma pneumoniae pneumonia, Immunoglobulin, Complement, Change, Children