布地奈德对支气管哮喘患者气道重塑及肺功能影响的疗效评价

doi:10.3969/j.issn.1000-8535.2015.03.009

广州医药 ›› 2015, Vol. 46 ›› Issue (3): 31-32.DOI: 10.3969/j.issn.1000-8535.2015.03.009

布地奈德对支气管哮喘患者气道重塑及肺功能影响的疗效评价

吴德泰, 肖红, 相英, 朱向阳

广东省东莞市大岭山镇大岭山医院儿科 (东莞 523820)

收稿日期:2015-01-26 出版日期:2015-05-20 发布日期:2021-11-30

Evaluation of Budesonide on airway remodeling and lung functionin in asthma

Wu Detai, Xiao Hong, Xiang Ying, et al

Department of Pediatrics, Hospital of Daling Shan, Dongguan 523820, China

Received:2015-01-26 Online:2015-05-20 Published:2021-11-30

摘要/Abstract

摘要： 目的本研究通过检测吸入布地奈德治疗支气管哮喘患儿前、后气道重塑、肺功能及外周血TGF-β浓度的变化,探讨布地奈德在哮喘患儿气道重塑早期干预的作用。方法将2013年1月—2014年10月在我院确诊为支气管哮喘患儿18例,给予规律吸入布地奈德治疗6个月,分别于治疗前、后检测肺功能、外周血TGF-β浓度以及通过高分辨CT(HRCT)测量支气管管壁厚度(T)并计算管壁面积(WA)、支气管管壁厚度与气管外径之比(WT%)、气道壁横截面面积占气道总截面积的的百分比(WA%)。结果吸入布地奈德治疗治疗6个月后,哮喘患儿WT%、WA%、肺功能以及TGF-β浓度均明显改善,与治疗前比较差异有统计学意义(P<0.05)。结论规律吸入布地奈德治疗能减轻支气管哮喘患儿早期气道重塑,改善肺功能,可能通过下调细胞因子TGF-β的表达有关。

关键词: 布地奈德, 支气管哮喘, 气道重塑, 肺功能

Abstract: Objective We detected the changes of Airway remodeling,lung function and peripheral blood concentrations of TGF-β in asthmatic children before and after inhaled budesonide, and explored the role of budesonide in airway remodeling before early intervention in asthmatic children. Methods 32 cases of children were diagnosed asthma in our hospital,and given treatment of inhaled budesonide for 6 months, and to detect lung function,pheral blood TGF-β concentration as well as measuring the bronchial wall thickness (T) and calculate the wall area (WA), the outer diameter of the trachea and bronchial wall thickness ratio (WT%), the cross-sectional area of the airway wall accounted for airway percentage (WA%) of the total cross-sectional area by high-resolution CT (HRCT) before and after treatment. Results After treatment with inhaled budesonide in six months, the asthma WT%, WA%, lung function, and TGF-β concentrations were significantly improved, the differences compared with that before treatment were statistically significant(P<0.05). Conclusion The treatment of inhaled budesonide can alleviate asthmatic airway remodeling in early, improve lung function,possibly related to down the expression TGF-β.

Key words: Budesonide, Asthma, Airway remode, Lung function

吴德泰, 肖红, 相英, 朱向阳. 布地奈德对支气管哮喘患者气道重塑及肺功能影响的疗效评价[J]. 广州医药, 2015, 46(3): 31-32.

Wu Detai, Xiao Hong, Xiang Ying, et al. Evaluation of Budesonide on airway remodeling and lung functionin in asthma[J]. Guangzhou Medical Journal, 2015, 46(3): 31-32.

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布地奈德对支气管哮喘患者气道重塑及肺功能影响的疗效评价

Evaluation of Budesonide on airway remodeling and lung functionin in asthma

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