广州医药 ›› 2015, Vol. 46 ›› Issue (3): 28-30.DOI: 10.3969/j.issn.1000-8535.2015.03.008

• 论著 • 上一篇    下一篇

小儿泌尿系统感染常见病原菌及耐药相关性分析

王洁琳, 李飞, 李家文, 钟秋月   

  1. 广州市妇女儿童医疗中心检验科(广州 510623)
  • 收稿日期:2015-01-07 出版日期:2015-05-20 发布日期:2021-11-30
  • 基金资助:
    广州市医药卫生科技自助项目(20121A011066)

Common pathogens and resistance correlation analysis caused by urinary tract infections in children

Wang Jielin, Li Fei, Li Jiawen, et al   

  1. Department of Clinical Laboratory, Guangzhou Women and Children's Medical Centre, Guangzhou 510623, China
  • Received:2015-01-07 Online:2015-05-20 Published:2021-11-30

摘要: 目的 探讨本中心引起儿童泌尿系统感染的常见病原菌的分布以及耐药情况,为临床合理选用抗菌药物提供参考。方法 回顾性分析本医疗中心2012年1月—2013年12月2463例泌尿系统感染患儿中段尿标本培养及药敏检测结果。结果 2463例患儿中段尿标本共培养病原菌479株,阳性率为19.45%。其中革兰阴性杆菌309株(64.51%),革兰阳性球菌138株(28.81%),真菌32株(6.68%,主要为白假丝酵母菌)。分离率前7位的病原菌依次为大肠埃希菌(36.53%)、肺炎克雷伯菌(12.73%)、粪肠球菌(D群)(12.32%)、屎肠球菌(D群)(10.23%)、真菌(6.68%)、铜绿假单胞菌(5.22%)、奇异变形菌(3.13%),革兰氏阴性杆菌以大肠埃希菌和肺炎克雷伯菌为主,其中产超广谱β‐内酰胺酶菌株125株,比例高达71.42%;革兰阳性球菌以肠球菌(D群)为主,金黄色葡萄球菌检出率为2.30%,其中耐甲氧西林株占27.27%。结论 大肠埃希菌仍为儿童泌尿系统感染的主要病原菌,且存在多重耐药菌感染情况,革兰氏阳性球菌有增多的趋势;明确病原菌种类及药敏结果,对临床合理应用抗菌药物治疗儿童泌尿系统感染有重要意义。

关键词: 儿童, 泌尿道感染, 病原菌, 耐药性

Abstract: Objective To research the distribution of common pathogenic bacteria and drug resistance of urinary tract infection in the hospital for providing reference of antimicrobial drugs for clinical reference. Methods Pathogenic bacteria isolated from the germiculture positive specimens of midstream urine and the antimicrobial susceptibility test results from Jan 2012 to Dec 2013 in our hospital were retrospective summarized. Results 479 strains pathogenic bacteria were isolated from 2463 urine samples totally. The positive rate was 17.3%, with 309 strains of gram-negative bacilli (64.51%),138 strains of gram-positive coccus(28.81%),32 strains of fungi(6.68%).The top 7 isolation of pathogens were strains of escherichia coli(36.53%),strains of klebsiella pneumoniae(12.73%),strains of enterococcus faecalis D group(12.32%),strains of enterococcus faecium D group(10.23%),strains of fungi(6.68%),strains of pseudomonas aeruginosa(5.22%),strains of staphylococcus epidermidis(3.13%).125 strains of klebsiella pneumoniae produced ESBL were detected out with the rates of up to 71.42%. The strains of gram-negative bacteria were based on enterococcus faecalis (D group),yet staphylococcus aureus methicillin resistant strains accounted for 27.27%. Conclusion Escherichia coli is the main pathogenic bacteria of child urinary tract infection and the multidrug resistance of the pathogenic bacteria is in a very serious situation. And gram-positive cocci is going to be increasing. It is necessary to make clear pathogens and drug sensitivity results, which is important to guide clinic make use of antibacterial agents exactly to cure infection of urinary system in children.

Key words: Child, Urinary tract infections, Pathogens, Resistance