肝胆胰外科中吲哚菁绿荧光成像技术的应用研究进展

doi:10.20223/j.cnki.1000-8535.2026.02.002

广州医药 ›› 2026, Vol. 57 ›› Issue (2): 133-143.DOI: 10.20223/j.cnki.1000-8535.2026.02.002

肝胆胰外科中吲哚菁绿荧光成像技术的应用研究进展

黄宇¹, 匡姣², 刘辉¹, 伍兆锋¹, 翁杰锋¹, 张帅³, 古维立⁴

1 华南理工大学附属第二医院（广州市第一人民医院）肝胆胰外科（广东广州 510180）;
2 华南理工大学附属第二医院（广州市第一人民医院）胃肠外科（广东广州 510180）;
3 华南理工大学附属第二医院（广州市第一人民医院）体检中心（广东广州 510180）;
4 广州医科大学附属中医医院肝胆外科（广东广州 510640）

收稿日期:2025-03-11 出版日期:2026-02-20 发布日期:2026-04-03
通讯作者: 古维立,E-mail：lili-6423@163.com
作者简介:古维立日本长崎大学医学博士,主任医师,博士生导师,日本长崎大学客座教授,现任广州医科大学附属中医医院肝胆外科主任导师。历任广州市第一人民医院大外科主任、普外科主任、肝胆胰外科主任。现为广州市医学会加速康复外科分会主任委员、广东省医学会加速康复外科分会副主任委员、广东省医师协会肝胆分会ERAS组组长、广东省医师协会肝胆分会胆道学组副组长、广东省医师协会普通外科分会副主任委员、日本肝胆胰外科学会委员。2015年获首届“羊城好医生”称号。主要研究方向：肝癌肿瘤干细胞构建肝癌类器官研究,肝纤维化再生机制与小分子药物影响的研究,肝脏移植免疫耐受机制的研究等。主持多项省项部级课题,获得国家发明及实用新型技术专利各1项。近三年以第一或通讯作者发表SCI论文15篇,累计影响因子60.9分。
基金资助:
广东省医学科研基金项目（A2024088）; 广州市科技计划项目（2024A03J1016）; 广州市中医药和中西医结合科技项目（20242A011001）

Progress of indocyanine green fluorescence imaging in hepatobiliary and pancreatic surgery

HUANG Yu¹, KUANG Jiao², LIU Hui¹, WU Zhaofeng¹, WENG Jiefeng¹, ZHANG Shuai³, GU Weili⁴

1 Department of HBP Surgery,Guangzhou First People's Hospital,the Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China;
2 Department of Gastrointestinal Surgery,Guangzhou First People's Hospital,the Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China;
3 Center of Physical Examination,Guangzhou First People's Hospital,the Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China;
4 Department of Hepatobiliary Surgery,the Affiliated TCM hospital of Guangzhou Medical University,Guangzhou 510640,China

Received:2025-03-11 Online:2026-02-20 Published:2026-04-03

摘要/Abstract

摘要： 吲哚菁绿（ICG）荧光成像技术基于ICG独特的代谢特性及近红外光激发特性,通过动态荧光显影成像为手术提供精准导航,其在肝胆胰外科领域展现出重要的应用价值。随着多版国内外指南的迭代更新,ICG荧光导航技术已被确立为肝胆胰外科手术的重要辅助手段,其安全性和有效性得到充分验证。文章就ICG荧光成像技术的原理、在肝胆胰外科应用中的现状、在临床应用中面临的问题以及其应用展望展开综述。

关键词: 吲哚菁绿, 荧光导航技术, 腹腔镜手术, 微创外科, 肝胆胰外科

Abstract: Based on the unique metabolic properties and near-infrared light excitation characteristics of indocyanine green（ICG）,the ICG fluorescence imaging technology provides dynamic fluorescence imaging for precise surgical navigation．This technology has demonstrated significant value in hepatobiliary and pancreatic surgery．With iterative updates to international and domestic guidelines,ICG-based fluorescence navigation has been established as an essential adjunctive tool in hepatopancreaticobiliary procedures,with its safety and efficacy validated through extensive clinical research．This review systematically explores the underlying principles of ICG fluorescence imaging,its current applications in liver,biliary,and pancreatic surgeries,the challenges encountered in clinical practice,and future directions for technological optimization and clinical translation．

Key words: indocyanine green, fluorescent navigation technology, laparoscopic surgery, minimally invasive surgery, hepatopancreaticobiliary surgery

黄宇, 匡姣, 刘辉, 伍兆锋, 翁杰锋, 张帅, 古维立. 肝胆胰外科中吲哚菁绿荧光成像技术的应用研究进展[J]. 广州医药, 2026, 57(2): 133-143.

HUANG Yu, KUANG Jiao, LIU Hui, WU Zhaofeng, WENG Jiefeng, ZHANG Shuai, GU Weili. Progress of indocyanine green fluorescence imaging in hepatobiliary and pancreatic surgery[J]. Guangzhou Medical Journal, 2026, 57(2): 133-143.

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肝胆胰外科中吲哚菁绿荧光成像技术的应用研究进展

Progress of indocyanine green fluorescence imaging in hepatobiliary and pancreatic surgery

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