急性下呼吸道感染住院患儿病毒病原学分析

doi:10.3969/j.issn.1000-8535.2018.03.017

广州医药 ›› 2018, Vol. 49 ›› Issue (3): 62-64.DOI: 10.3969/j.issn.1000-8535.2018.03.017

急性下呼吸道感染住院患儿病毒病原学分析

黄育涛, 蔡幸生, 朱勇斌

揭阳市人民医院(揭阳 522000)

收稿日期:2018-02-26 出版日期:2018-05-20 发布日期:2021-12-01
通讯作者: 黄育涛,E-mail:113605450@qq.com
基金资助:
揭阳市医学科研项目(201612)

Analysis of viral etiology in hospitalized children with acute lower respiratory tract infection

HUANG Yutao, CAI Xingsheng, ZHU Yongbin

The People's Hospital of Jieyang City, Jieyang 522000, China

Received:2018-02-26 Online:2018-05-20 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨揭阳地区急性下呼吸道感染住院患儿病毒病原学特点。方法对2 125例急性下呼吸道感染患儿应用直接免疫荧光法(DIF)进行A型流感病毒(甲型流感病毒IFA)、B型流感病毒(乙型流感病毒IFB)、呼吸道合胞病毒(RSV)、腺病毒(AdV)、副流感病毒1(PIVⅠ)、2(PIVⅡ)和3型(PIVⅢ)进行病毒学检测。结果 2 125例患儿鼻咽部分泌物标本中有538例检测出至少1种病毒,总阳性率25.3％,其中RSV 阳性率(19.7%)明显高于其他病毒,具有统计学意义。春、夏、冬季的RSV阳性率大致相当,明显高于秋季。婴儿期组RSV阳性率(27.2%)最高,幼儿期组(18.7%)次之,均显著高于学龄前期、学龄期,后2组阳性率无统计学差异,青春期组未检出RSV。结论病毒是急性下呼吸道感染的重要病原体,而其中又以RSV为著,RSV感染具有显著的季节性和年龄特征性。

关键词: 急性下呼吸道感染, 病毒, 直接免疫荧光法

Abstract: Objective To investigate the viral etiology feature in hospitalized children with acute lower respiratory infection in Jieyang area. Methods A total of 2 125 children with acute lower respiratory tract infection were screened by direct immune fluorescence assay (DIF) for influenza virus A (IFA), influenza virus B (IFB), respiratory syncytial virus (RSV), adenovirus (AdV), parainfluenza virus I (PIV Ⅰ), PIV Ⅱ and PIV Ⅲ. Results In 2 125 cases of nasopharyngeal secretory specimens, 538 cases were detected at least one kinds of viruses. The total positive rate was 25.3%, of which the positive rate of RSV (19.7%) was higher than that of other viruses. The positive rate of RSV was similar in spring, summer and winter, much higher than that in autumn.The positive rate of RSV in infancy group (27.2%) was the highest,then the second was the toddler's age(18.7%), both of which were higher than that in preschool age group and school age group. There was no significant difference in the positive rate between preschool age group and school age group. In addition, RSV was not detected in the adolescence group. Conclusion Virus is an important pathogen of acute lower respiratory tract infection. The most common virus is RSV, infection of which has seasonal and age characteristics.

Key words: Acute lower respiratory infection, Virus, Direct immunofluorescenceassay

黄育涛, 蔡幸生, 朱勇斌. 急性下呼吸道感染住院患儿病毒病原学分析[J]. 广州医药, 2018, 49(3): 62-64.

HUANG Yutao, CAI Xingsheng, ZHU Yongbin. Analysis of viral etiology in hospitalized children with acute lower respiratory tract infection[J]. Guangzhou Medical Journal, 2018, 49(3): 62-64.

参考文献

[1] JOHNSON J I, RATARD R. Respiratory syncytial virusassociated hospitalizations in Louisiana[J]. J La State Med Soc,2012, 1640(5): 268-273.
[2] 胡伟. 9项呼吸道病原体检测在呼吸道感染病因分析中的应用 [J]. 国际检验医学杂志,2013,34(23):3158-3161.
[3] 赵延香.小儿肺炎的细菌学耐药性分析与检验质量控制 [J]. 中国医学创新,2015,12(31):124-127.
[4] LIM F J, DE KLERK N, BLYTH C C, et al. Systematic review and meta-analysis of respiratory viral coinfections in children[J]. Respirol,2016,21(4):648-655.
[5] 于德山,任丽丽,陈建华,等.白银市5岁以下急性下呼吸道感染住院儿童病原学分析[J]. 中国病毒病杂志,2017,7(5):360-364.
[6] 江艳微,华军,吴婧,等.苏州地区5岁以下严重急性呼吸道感染(SARI)住院患儿的病毒病原学和临床特征分析[J]. 复旦学报:医学版,2013,40(4):407-412.
[7] 马文瑛,张慧,姜中毅,等.兰州市2009－2013年住院病例中严重急性呼吸道感染病毒病原学监测研究[J]. 中国病毒病杂志,2015,5(4):281-286.
[8] SYRMIS M W, WHILEY D M, THOMAS M, et al. A sensitive, specific, and cost - effective multiplex reverse transcripatase-PCR assay for the detection of seven common respiratory viruses in respiratory samples[J]. J Mol Diagn, 2004, 6(2): 125-131.
[9] 黄志英,程宝金,林红,等.江苏省常州地区急性呼吸道感染患儿呼吸道合胞病毒流行病学特点[J]. 实用临床医药杂志,2014,18(1):125-127.
[10] 江载芳,申昆玲,沈颖,等.诸福棠实用儿科学[M]. 第8版.北京:人民卫生出版社, 2015:938.
[11] LU L,YAN Y,YANG B,et al.Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou,China[J]. BMC Infect Dis,2015(15):431.
[12] 张亚丽,林海玲,兰菊红,等.急性下呼吸道感染住院患儿呼吸道合胞病毒感染分析[J]. 中国小儿急救医学,2014,21(3):143-144.
[13] GHASEMI Y,MAKVANDI M,SAMARBAFZADEH A R,et al.Serotype determination of adenoviruses in children with respiratory infection[J]. Indian J Pediatr,2014,81(7):639-643.
[14] BACKMAN K,PIIPPO-SAVOLAINEN E,OLLIKAINEN H, et al. Adults face increased asthma risk after infant RSV bronchiolitis and reduced respiratory health-related quality of life after RSV pneumonia[J]. Acta Paediatr, 2013, 103(8): 850-855.

急性下呼吸道感染住院患儿病毒病原学分析

Analysis of viral etiology in hospitalized children with acute lower respiratory tract infection

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