胃蛋白酶原、胃泌素17和HP感染与慢性萎缩性胃炎和肠上皮化生的相关性

doi:10.3969/j.issn.1000-8535.2018.03.007

广州医药 ›› 2018, Vol. 49 ›› Issue (3): 26-28.DOI: 10.3969/j.issn.1000-8535.2018.03.007

胃蛋白酶原、胃泌素17和HP感染与慢性萎缩性胃炎和肠上皮化生的相关性

伦伟健, 梁晓燕, 黄鹤

佛山市南海区人民医院(佛山 528000)

收稿日期:2018-01-23 出版日期:2018-05-20 发布日期:2021-12-01
基金资助:
佛山市医学类科技攻关项目(2015AB000302)

Correlation in pepsinogen,gastrin 17 and helicobacter pylori infection, chronic atrophic gastritis and intestinal metaplasia

LUN Weijian, LIANG Xiaoyan, HUANG He

Foshan Nanhai District People's Hospital, Foshan 528000,China

Received:2018-01-23 Online:2018-05-20 Published:2021-12-01

摘要/Abstract

摘要： 目的研究血清胃蛋白酶原(PG)、胃泌素17(G-17)水平和HP感染与慢性萎缩性胃炎(CAG)和肠上皮化生的相关性。方法连续选择2016年6月—2017年6月于我院诊断慢性非萎缩性胃炎60例,CAG 40例和肠上皮化生40例,比较患者血清PGI、II和PGI/II,G-17水平以及HP阳性感染率。结果 CAG和肠上皮化生患者PGI和PGI/II低于非萎缩性胃炎患者,而PGII水平升高,G-17水平和HP阳性感染率也增加,差异均有统计学意义(P＜0.05)。结论血清PG、G-17水平和HP感染是CAG和肠上皮化生的重要机制。

关键词: 胃蛋白酶原, 胃泌素17, 幽门螺旋杆菌, 慢性萎缩性胃炎, 肠上皮化生

Abstract: Objective To study correlation in serum pepsinogen(PG),gastrin 17(G-17) levels and helicobacter pylori(HP) infection and chronic atrophic gastritis(CAG), intestinal metaplasia. Methods A total of 60 cases as non-CAG,40 of CAG and other 40 of intestinal metaplasia from June 2016 to June 2017 were consecutives enrolled, then to compare differences of serum PGI,II,PGI/II,G-17 levels, HP infection positive rate. Results The PGI and PGI/II values in patients with CAG and intestinal metaplasia were both lower than non-CAG patients, while PGII level got more,G-17 level and HP infection positive rate were higher too(P＜0.05). Conclusion The expressions of serum PG,G-17 and HP infection may be the important mechanism to CAG and intestinal metaplasia.

Key words: Pepsinogen, Gastrin 17, Helicobacter pylori, Chronic atrophic gastritis, Intestinal metaplasia

伦伟健, 梁晓燕, 黄鹤. 胃蛋白酶原、胃泌素17和HP感染与慢性萎缩性胃炎和肠上皮化生的相关性[J]. 广州医药, 2018, 49(3): 26-28.

LUN Weijian, LIANG Xiaoyan, HUANG He. Correlation in pepsinogen,gastrin 17 and helicobacter pylori infection, chronic atrophic gastritis and intestinal metaplasia[J]. Guangzhou Medical Journal, 2018, 49(3): 26-28.

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胃蛋白酶原、胃泌素17和HP感染与慢性萎缩性胃炎和肠上皮化生的相关性

Correlation in pepsinogen,gastrin 17 and helicobacter pylori infection, chronic atrophic gastritis and intestinal metaplasia

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