香芹酚的解酒护肝作用的研究

doi:10.3969/j.issn.1000-8535.2021.01.004

广州医药 ›› 2021, Vol. 52 ›› Issue (1): 18-21.DOI: 10.3969/j.issn.1000-8535.2021.01.004

香芹酚的解酒护肝作用的研究

易杭¹, 徐启钟¹, 陈桢昌¹, 欧仲越¹, 谢晓桐¹, 黄乐琪¹, 朱晓琴²

1 广州医科大学第二临床学院(广州 510045)
2 广州医科大学基础学院机能实验中心(广州 510045)

收稿日期:2020-07-20 出版日期:2021-01-20 发布日期:2021-11-22
通讯作者: 朱晓琴,E-mail:whzhuxiaoqin@163.com
基金资助:
广州医科大学第二临床学院大学生科技创新项目(2018YA03)

Stdudy on the antialcoholism and liver protecting effects of carvacrol

YI Hang¹, XU Qizhong¹, CHEN Zhenchang¹, OU Zhongyue¹, XIE Xiaotong¹, HUANG Yueqi¹, ZHU Xiaoqin²

1 The Second Clinical College, Guangzhou Medical University, Guangzhou 511436, China
2 Academic College, Guangzhou Medical University, Guangzhou 511436, China

Received:2020-07-20 Online:2021-01-20 Published:2021-11-22

摘要/Abstract

摘要： 目的观察香芹酚的解酒护肝作用。方法将实验小鼠随机分为实验组(低剂量香芹酚组,中剂量香芹酚组,高剂量香芹酚组),生理盐水对照组和阳性对照组,观察小鼠行为学,醉酒小鼠的醉酒时间和醉酒潜伏期,检测血液中的乙醇浓度和肝组织中的SOD和MDA,计算肝比重。结果与实验组比较,低,中,高剂量组香芹酚分别能显著延长小鼠的醉酒潜伏期(P<0.05),同时,各剂量的香芹酚组均可使肝组织中丙二醛(MDA)含量降低(P<0.05),肝组织中超氧化物歧化酶(SOD)活性分别增加(P<0.05)。结论香芹酚具有解酒护肝作用,其作用机理可能与抗氧化活性有关。

关键词: 香芹酚, 解酒, 护肝, 氧化应激

Abstract: Objective To observe the effect of carvacrol on MDA and SOD in acute alcoholic liver injury. Methods The experimental mice were randomly divided into the experimental group (low-dose carvacrol group, medium-dose carvacrol group, high-dose carvacrol group), normal saline control group and positive control group. The behavior of the mice was observed, the time and incubation period of drunkenness of the mice were observed, the concentration of alcohol in blood and SOD and MDA in liver tissues were detected, and the specific gravity of the liver was calculated. Results Compared with the experimental group, carvacrol in the low, medium and high dose groups could prolong the intoxication incubation period of mice (P<0.05), meanwhile, the content of malonaldehyde (MDA) in liver tissues was reduced in the carvacrol group (P<0.05), and the activity of superoxide dismutase (SOD) in liver tissues was increased in the carvacrol group (P<0.05). Conclusion Carvacrol has antialcoholism and liver protecting effects, and its mechanism may be related to antioxidant activity.

Key words: Carvacrol, Anti-alcohol, Liver protection, Oxidant stress

易杭, 徐启钟, 陈桢昌, 欧仲越, 谢晓桐, 黄乐琪, 朱晓琴. 香芹酚的解酒护肝作用的研究[J]. 广州医药, 2021, 52(1): 18-21.

YI Hang, XU Qizhong, CHEN Zhenchang, OU Zhongyue, XIE Xiaotong, HUANG Yueqi, ZHU Xiaoqin. Stdudy on the antialcoholism and liver protecting effects of carvacrol[J]. Guangzhou Medical Journal, 2021, 52(1): 18-21.

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香芹酚的解酒护肝作用的研究

Stdudy on the antialcoholism and liver protecting effects of carvacrol

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