电针联合草酸艾司西酞普兰治疗对抑郁障碍患者抑郁状态的影响

doi:10.3969/j.issn.1000-8535.2021.01.003

广州医药 ›› 2021, Vol. 52 ›› Issue (1): 12-17.DOI: 10.3969/j.issn.1000-8535.2021.01.003

电针联合草酸艾司西酞普兰治疗对抑郁障碍患者抑郁状态的影响

古智文¹, 黄雄², 薛丹³

1 广州市第一人民医院精神心理科(广州 510180)
2 广州医科大学附属脑科医院精神科(广州 510370)
3 广州市第一人民医院中医科(广州 510180)

收稿日期:2020-06-22 出版日期:2021-01-20 发布日期:2021-11-22
通讯作者: 黄雄,E-mail:hxiong1968@163.com
基金资助:
广州市中医药和中西医结合科技项目(20182A010009)

The effect of electroacupuncture combined with escitalopram oxalate on cognitive function in patients with depression

GU Zhiwen¹, HUANG Xiong², XUE Dan³

1 Department of Psychiatry, Guangzhou First People's Hospital,Guangzhou 510180,China
2 Department of Psychiatry, Brain Hospital of Guangzhou Medical University,Guangzhou 510370,China
3 Department of Traditional Chinese Medicine, Guangzhou First People's Hospital,Guangzhou 510180,China

Received:2020-06-22 Online:2021-01-20 Published:2021-11-22

摘要/Abstract

摘要： 目的研究电针治疗对重性抑郁障碍患者的抑郁状态的影响。方法本研究共分为3组,药物组、和药物+电针组及对照组(每组各50 例),药物组给予艾司西酞普兰抗抑郁治疗连续6周,药物+电针组在给予艾司西酞普兰抗抑郁治疗的基础上,进行电针治疗6周。比较治疗前后三组的HAMD 24 项评分,并对三组的HAMD 24 项评分与血清细胞炎症因子IL-1β、IL-2、IL-6、TNF-α水平进行相关性分析。采用多元逐步回归法,分析影响基线药物组和药物+电针组HAMD 24 项评分的主要因素。结果与治疗前比较,药物组和药物+电针组患者治疗后HAMD 24 项评分均降低,差异有统计学意义(P＜0.05或P＜0.01),与药物组比较,治疗后药物+电针组HAMD 24 项评分较低,差异有统计学意义(P＜0.05或P＜0.01)。药物组HAMD 24 项评分与血清细胞炎症因子IL-6(r=0.335,P<0.001)、TNF-α(r=0.269,P<0.001)、IL-2(r=0.257,P=0.001)和IL-1β(r=0.205,P=0.021)呈正相关。药物+电针组HAMD24 项评分与血清细胞炎症因子IL-6(r=0.338,P<0.001)、TNF-α(r=0.271,P<0.001)、IL-2(r=0.255,P=0.015)和IL-1β呈正相关(r=0.208,P=0.026)。影响药物组HAMD24 项评分的主要因素有:血清细胞炎症因子IL-6、TNF-α、IL-1β、IL-2、婚姻(已婚)、文化程度(受教育年限少),标准化回归系数分别为0.585、0.516、0.452、0.318、-0.290、0.262(P＜0.05或P＜0.01)。影响药物+电针组HAMD24 项评分的主要因素有:血清细胞炎症因子IL-6、TNF-α、IL-2、IL-1β、婚姻(已婚)、文化程度(受教育年限少),标准化回归系数分别为0.592、0.521、0.448、0.323、-0.295、0.271(P＜0.05或P＜0.01)。结论药物联合电针治疗能有效改善重性抑郁障碍患者的抑郁状态,细胞炎症因子与HAMD24 项评分相关,可影响重性抑郁障碍患者的抑郁状态。

关键词: 电针, 重性抑郁障碍,认知功能, 细胞炎症因子

Abstract: Objective To explore the effect of electroacupuncture on patients with severe depression. Methods Patients was divided into three groups, acupuncture group, drug group and the control group. Each group had 50 patients. The drug group was treated with escitalopram for 6 weeks.The acupuncture group were treated with escitalopram and electroacupuncture for 6 weeks. We compared the HAMD24 among 3 groups before or after treatment. The correlation of the levels of IL-1 β, IL- 2, IL- 6, TNF-α and the total HAMD24 score among 3 groups were taken by the correlation analysis. And the main factors influencing the total HAMD24 score before the study were analyzed by the multiple inear step regression method. Results Compared with the pre-treatment group, the HAMD score of the drug group and the acupuncture group decreased after treatment, the difference was statistically significant (P<0.05 or P<0.01). Compared with the drug group, the HAMD score of the acupuncture group was lower after treatment; the difference was statistically significant (P<0.05 or P<0.01). The drug group, HAMD scores were positively correlated with IL- 6, TNF-α, IL- 2 and IL-1 β (r=0.335, 0.269, 0.257 and 0.205, respectively, P<0.05 or P<0.01). The acupuncture group HAMD scores were positively correlated with IL- 6, TNF-α, IL- 2 and IL-1 β(r=0.338, 0.271, 0.255 and 0.208, respectively, P<0.05 or P<0.01). The main factors influencing the HAMD score before the study included: serum cytokines IL- 6, TNF-α, IL β, IL- 2, marriage and education. The standardized regression coefficients were 0.585,- 0.516, 0.452, 0.318, 0.290, 0.262, respectively (P<0.05 or P<0.01). The main factors influencing the HAMD score of the drug group before the study included: serum cytokines IL- 6, TNF-α, IL β, IL- 2, marriage and education. The standardized regression coefficients were 0.585,- 0.516, 0.452, 0.318, 0.290, 0.262, respectively (P<0.05 or P<0.01). The main factors of the acupuncture group influencing the HAMD score before the study included: serum cytokines IL- 6, TNF-α, IL β, IL- 2, marriage and education. The standardized regression coefficients were 0.592,0.521,0.448,0.323,- 0.295,0.271(P＜0.05 or P＜0.01). Conclusion Escitalopram combination with electroacupuncture may improve the the depressive state. Inflammatory cytokines were associated with HAMD24 scores and it affects the depressive state of patients with major depressive disorder.

Key words: Electroacupuncture, Major depressive disorder, Cognitive function, Inflammatory cytokines

古智文, 黄雄, 薛丹. 电针联合草酸艾司西酞普兰治疗对抑郁障碍患者抑郁状态的影响[J]. 广州医药, 2021, 52(1): 12-17.

GU Zhiwen, HUANG Xiong, XUE Dan. The effect of electroacupuncture combined with escitalopram oxalate on cognitive function in patients with depression[J]. Guangzhou Medical Journal, 2021, 52(1): 12-17.

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电针联合草酸艾司西酞普兰治疗对抑郁障碍患者抑郁状态的影响

The effect of electroacupuncture combined with escitalopram oxalate on cognitive function in patients with depression

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