氟伐他汀联合环磷腺苷葡胺治疗慢性肺心病急性加重期疗效观察

doi:10.3969/j.issn.1000-8535.2016.03.024

广州医药 ›› 2016, Vol. 47 ›› Issue (3): 66-68.DOI: 10.3969/j.issn.1000-8535.2016.03.024

氟伐他汀联合环磷腺苷葡胺治疗慢性肺心病急性加重期疗效观察

林雄方¹, 陈浩²

1 广东江门鹤山人民医院急诊科 (江门 529700)
2 广东省人民医院消化内科 (广州 510000)

收稿日期:2016-01-26 出版日期:2016-05-20 发布日期:2021-11-30
通讯作者: 林雄方,E-mail:lxf2043@sina.com

Observation of the clinical efficacy of Fluvastatin combined with Meglumine Adenosine Cyclophosphate on acute exacerbation of chronic pulmonary heart disease

Lin Xiongfang, Chen Hao

Lin Xiongfang. Emergency Department,Guangdong Heshan People's hospital,Heshan 529700, China
Chen Hao. Department of Gastroenterology,Guangdong General Hospital,Guangzhou 510000,China

Received:2016-01-26 Online:2016-05-20 Published:2021-11-30

摘要/Abstract

摘要： 目的观察氟伐他汀联合环磷腺苷葡胺治疗慢性肺心病急性加重期的临床疗效。方法将我院收治的74例慢性肺心病急性加重期病人,使用随机数字表法分为联合用药组与对照组,每组各37例。对照组单独使用环磷腺苷葡胺,联合用药组在对照组的基础上加服氟伐他汀。两组疗程均为7周。观察比较两组患者治疗前后的NO,ET-1,CRP,PaO₂水平以及治疗效果。结果经7周疗程治疗后,对照组有效率为64.86%,联合用药组94.59%。两组间比较,差异有统计学意义(P<0.05)。两组NO,ET-1,CRP,PaO₂水平比较,联合用药组均优于对照组,差异有统计学意义(P<0.05)。结论氟伐他汀联合环磷腺苷葡胺治疗慢性肺心病急性加重期的临床疗效更为显著,值得临床推广。

关键词: 肺心病, 氟伐他汀, 环磷腺苷葡胺

Abstract: Objective To observe the clinical efficacy of combined treatment of Fluvastatin combined with Meglumine Adenosine Cyclophosphate on acute exacerbation of chronic pulmonary heart disease. Methods 74 patients with acute exacerbation of chronic pulmonary heart disease were randomly divided into combined treatment group and control group. The control group was treated by Meglumine Adenosine Cyclophosphate for 7 weeks.The combined treatment group was treated by Meglumine Adenosine Cyclophosphate and Fluvastatin for 7 weeks. The clinical efficacy and the score of NO,CRP,ET-1,PaO₂ were assessed before and after the treatment. Results After 7 weeks treatment, the total clinical efficacy rate was 64.86% in the control group and 94.59% in the combined treatment group. The differences between them has statistically significant(P<0.05). The score of NO,ET-1,CRP,PaO₂ in combined treatment group were significantly improved compared to control group (P<0.05). Conclusion The clinical efficacy of Fluvastatin combined with Meglumine Adenosine Cyclophosphate on acute exacerbation of chronic pulmonary heart disease is more efficient. It is worth to develop clinically.

Key words: Pulmonary heart disease, Fluvastatin, Meglumine Adenosine Cyclophosphate

林雄方, 陈浩. 氟伐他汀联合环磷腺苷葡胺治疗慢性肺心病急性加重期疗效观察[J]. 广州医药, 2016, 47(3): 66-68.

Lin Xiongfang, Chen Hao. Observation of the clinical efficacy of Fluvastatin combined with Meglumine Adenosine Cyclophosphate on acute exacerbation of chronic pulmonary heart disease[J]. Guangzhou Medical Journal, 2016, 47(3): 66-68.

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氟伐他汀联合环磷腺苷葡胺治疗慢性肺心病急性加重期疗效观察

Observation of the clinical efficacy of Fluvastatin combined with Meglumine Adenosine Cyclophosphate on acute exacerbation of chronic pulmonary heart disease

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