关键词: 肝癌, 肝癌根治术, 恶心呕吐, 影响因素, 化学治疗, 严重程度

Abstract: Objective To explore the status and influencing factors of nausea and vomiting after radical resection of liver cancer. Methods A retrospective analysis was conducted on 70 liver cancer patients admitted to the Second People’s Hospital of Tianjin from May 2022 to May 2024. All patients underwent radical surgery for liver cancer,and their postoperative nausea and vomiting conditions were analyzed. According to the occurrence of nausea and vomiting,30 patients who experienced nausea and vomiting after surgery were divided into an observation group,and the remaining 40 patients were divided into a control group. The clinical and pathological characteristics as well as perioperative indicators between two groups of patients were compared. A logistic regression model was established to analyze the influencing factors of postoperative nausea and vomiting in liver cancer patients after surgical resection,with postoperative nausea and vomiting as the dependent variable. Results The incidence of postoperative nausea and vomiting in liver cancer patients was 42. 86%（30/70）,including 14 cases of grade I,accounting for 20. 00%,10 cases of grade II,accounting for 14. 29%,four cases of grade III,accounting for 5. 71%,and two cases of grade IV,accounting for 2. 86%. There were no significant differences in gender,body mass index（BMI）,pathological type,clinical stage,and preoperative fasting time between the observation group and the control group（P>0. 05）. However,there were significant differences in age and chemotherapy status between the observation group and the control group（P<0. 05）. There were no significant differences in the operation time,postoperative VAS score,anesthesia method and postoperative complications between the observation group and the control group（P>0. 05）,but with differences in the portal block time,intraoperative blood loss and postoperative abdominal distension between the observation group and the control group（P<0. 05）. Age,chemotherapy,intraoperative blood loss,and postoperative abdominal distension were independent influencing factors for postoperative nausea and vomiting in liver cancer patients undergoing surgical resection（P<0. 05）. Conclusions The incidence of nausea and vomiting after surgical resection in liver cancer patients is relatively high,with age,chemotherapy,intraoperative blood loss,and postoperative abdominal distension may be influencing factors for nausea and vomiting. Therefore,relevant measures should be taken in a timely manner to intervene in high-risk patients to prevent postoperative nausea and vomiting and reduce its severity.

Key words: liver cancer, radical surgery for liver cancer, nausea and vomiting, influencing factors, chemotherapy, severity degree