儿童孤立性直肠溃疡综合征的诊治进展

doi:10.20223/j.cnki.1000-8535.2025.09.003

广州医药 ›› 2025, Vol. 56 ›› Issue (9): 1175-1181.DOI: 10.20223/j.cnki.1000-8535.2025.09.003

儿童孤立性直肠溃疡综合征的诊治进展

马泓镔¹, 熊莉娅², 王洪丽²

1 广州医科大学儿科学院（广东广州 511436）;
2 广州医科大学附属广州市妇女儿童医疗中心消化科,国家儿童区域医疗中心（中南）（广东广州 510623）

收稿日期:2024-07-09 出版日期:2025-09-20 发布日期:2025-10-31
通讯作者: 王洪丽,E-mail：94126186@qq.com
基金资助:
广州市基础研究计划市校院联合资助项目（202202020631）

Advances in the diagnosis and treatment of isolated rectal ulcer syndrome in children

MA Hongbin¹, XIONG Liya², WANG Hongli²

1 School of Pediatrics, Guangzhou Medical University, Guangzhou 511436, China;
2 Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China

Received:2024-07-09 Online:2025-09-20 Published:2025-10-31

摘要/Abstract

摘要： 儿童孤立性直肠溃疡综合征（SRUS）是一种较为罕见的慢性直肠疾病,儿童发病率低且缺乏明确统计学数据。该病主要表现为便血、排黏液便和排便不尽感,临床诊断较为困难,常易误诊为其他疾病。其发病机制尚不明确,可能与排便习惯异常、直肠黏膜异常、血管异常以及遗传易感性等多种因素有关,其中 CHEK2 基因的 p.H371Y 突变可能在发病机制中起关键作用。诊断需综合病史、体格检查以及排粪造影、超声内镜、肠镜检查与组织病理活检等多种辅助检查手段。治疗上目前尚无统一指南,主要包括改善饮食和排便习惯、生物反馈治疗、药物治疗、内镜下治疗和外科手术治疗等,但总体治疗难度较大且复发率较高。本文对儿童 SRUS 的流行病学、发病机制、临床表现、诊断和治疗等方面的研究进展进行综述,旨在提高临床医师对该病的诊疗水平,为未来进一步的研究提供参考依据。

关键词: 孤立性直肠溃疡综合征, 儿童, 诊断, 治疗

Abstract: Solitary rectal ulcer syndrome（SRUS）in children is a chronic and benign disease of the rectum characterized by ulcers. The clinical incidence of SRUS in children is not high,but it is prone to misdiagnose and miss diagnosis,which can delay the optimal treatment opportunity. This article reviews the research progress on the epidemiology,pathogenesis,clinical manifestations,diagnosis and treatment of SRUS in children,aiming to improve the diagnostic and therapeutic level of clinicians.

Key words: isolated rectal ulcer syndrome, children, diagnosis, treatment

马泓镔, 熊莉娅, 王洪丽. 儿童孤立性直肠溃疡综合征的诊治进展[J]. 广州医药, 2025, 56(9): 1175-1181.

MA Hongbin, XIONG Liya, WANG Hongli. Advances in the diagnosis and treatment of isolated rectal ulcer syndrome in children[J]. Guangzhou Medical Journal, 2025, 56(9): 1175-1181.

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儿童孤立性直肠溃疡综合征的诊治进展

Advances in the diagnosis and treatment of isolated rectal ulcer syndrome in children

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