可注射水凝胶药物递送系统在肿瘤治疗中的应用

doi:10.20223/j.cnki.1000-8535.2025.08.004

摘要/Abstract

摘要： 肿瘤治疗仍然是生物医学研究的一个突出领域。围绕各种化学治疗（化疗）药物和其他治疗药物的不良反应和靶向疗效的研究推动了各种药物载体的发展。这些载体聚焦于提高肿瘤部位的药物浓度,最大限度地减少全身不良反应,并改善治疗效果。在已报道的递送系统中,可注射水凝胶由于其微创的药物递送特性,已成为化疗药物体内递送的重要载体形式。文章系统地总结了可注射水凝胶的类型和特征,并进一步概括了可注射水凝胶装载药物的方式,同时深入讨论可注射水凝胶在治疗肿瘤的各种药物的递送应用。文章对原位注射水凝胶在治疗肿瘤方面存在的潜在性挑战和可能的解决方案提供了动态前瞻性的参考。可注射的水凝胶作为药物传递系统用于肿瘤治疗具有良好的发展前景。

关键词: 可注射, 水凝胶, 药物递送, 肿瘤治疗

Abstract: Tumor treatment remains a prominent area of biomedical research．The researches surrounding the adverse reactions and targeted efficacy of various chemotherapy drugs and other therapeutic drugs have driven the development of various drug carriers．These carriers focus on increasing drug concentration at tumor site,minimizing systemic adverse reactions,and improving treatment outcomes．In the reported delivery systems,injectable hydrogels have become an important carrier for the delivery of chemotherapeutic drugs in vivo due to their minimally invasive characteristics．This review systematically summarized the types and characteristics of injectable hydrogels,and further summarized their drug loading methods．At the same time,the application of injectable hydrogels in the delivery of various drugs for tumor treatment was discussed in depth．This review provides dynamic and prospective reference for the potential challenges and possible solutions of the in situ injectable hydrogels for tumor therapy．Injectable hydrogels as drug delivery systems are with good prospects for tumor treatment．

Key words: injectable, hydrogel, drug delivery, tumor treatment

董强, 赵志虎. 可注射水凝胶药物递送系统在肿瘤治疗中的应用[J]. 广州医药, 2025, 56(8): 1035-1044.

DONG Qiang, ZHAO Zhihu. The application of injectable hydrogels as drug delivery systems in tumor treatment[J]. Guangzhou Medical Journal, 2025, 56(8): 1035-1044.

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