干细胞疗法及神经调控技术在脊髓损伤中的研究进展

doi:10.3969/j.issn.1000-8535.2024.07.001

广州医药 ›› 2024, Vol. 55 ›› Issue (7): 689-704.DOI: 10.3969/j.issn.1000-8535.2024.07.001

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干细胞疗法及神经调控技术在脊髓损伤中的研究进展

张彩玲^1,2, 兰月², 马瑗锾¹

1 华南理工大学附属第二医院（广州市第一人民医院）临床医学研究所（广东广州 510180）;
2 华南理工大学附属第二医院（广州市第一人民医院）康复医学科（广东广州 510180）

收稿日期:2024-04-09 出版日期:2024-07-20 发布日期:2024-08-21
通讯作者: 马瑗锾,E-mail：eymayuanhuan@scut.edu.cn;兰月,E-mail：bluemooning@163.com
作者简介:马瑗锾 华南理工大学附属第二医院（广州市第一人民医院）临床医学研究所，副研究员，医学博士，硕士研究生导师。国家自然科学基金及广东省自然科学基金评审专家，教育部学位论文评审专家，广东省专家库在库专家。中国研究型医院学会神经再生与修复专业委员会委员，北大核心期刊《中国组织工程研究》杂志社医工融合联盟委员，广东省自然医学研究会干细胞与中医再生医学专业委员会常务委员。Frontiers in Molecular Neuroscience、Neurospine、Bioengineering、Journal of Neurotrauma等多个国际期刊审稿人，《广州医药》杂志编委。
主要研究方向：干细胞再生医学、组织工程、生物材料、神经调控技术等修复中枢神经系统损伤的基础和临床转化研究。在国际上发表科研论文 20余篇，其中第一或通讯作者6篇，授权发明专利2项，实用新型专利1项，主持国家级课题1项，省部级课题3项。荣获《中国组织工程研究》杂志2023年优秀审稿专家，作为主要完成人研究成果荣获2022年广东省医学科技奖一等奖。
兰月华南理工大学附属第二医院（广州市第一人民医院）康复医学科主任。博士，主任医师/教授，华南理工大学基础医学博士生导师，暨南大学临床医学博士生导师，博士后合作导师。广州市“老年衰弱与神经康复”重点实验室负责人，广东省杰出青年医学人才，广州市医学重点人才，岭南英杰工程后备人才培养对象。美国佛罗里达大学访问学者。国家自然科学基金评审专家，广州市科技与信息化局科技项目评审专家，国家级大学生创新训练项目指导老师。现为中国康复医学会脑功能检测与调控康复分会副主任委员。广东省医学会社区康复分会副主任委员，广东省康复医学会吞咽障碍分会副主任委员，广东省康复医学会神经调控分会副主任委员，广州市医学会康复医学分会副主任委员，广州市医学会物理医学与康复分会副主任委员。任Brain Network and Modulation副主编，Frontier in neurology客座编辑，《中华物理医学与康复杂志》通讯编委，《广州医药》杂志编委，Dysphagia、《中国康复医学杂志》审稿专家。
主要研究方向：老年康复与神经康复，专注于卒中后功能障碍的生物力学及功能重组机制、经颅磁刺激精准靶向治疗及脑可塑性，老年虚弱的早期预防及干预等研究。擅长老年性疾病、脑血管疾病、脑外伤、脊髓损伤的诊断与治疗，脑损伤后功能障碍的评估与治疗，老年性疾病预后及生活质量研究。2010—2011年获国家留学基金委资助赴美国佛罗里达大学吞咽研究所，师从美国著名吞咽障碍专家、吞咽研究领域的先驱Micheal A.Crary教授进行吞咽障碍的生物力学及功能重组机制研究。回国后在国内率先开展吞咽造影数字化分析及高分辨率咽动力检测等创新性吞咽功能量化评定技术，突破了既往研究中吞咽功能无法量化评定的瓶颈，提高了对临床上疑难复杂的吞咽障碍诊断与治疗能力。
目前主持国家自然科学基金5项，广东省公益研究与能力建设重点项目，广州市产学研协同创新重大项目等省部级课题5项，其他课题4项。参与国家重点研发计划、国家“十五”“十一五”科技攻关项目分课题、中国芬兰政府间科技合作项目等多项。获得发明及实用新型技术专利5项，计算机软件著作权2项。国内外核心期刊发表论文70余篇，其中第一作者或通讯作者SCI论文50余篇。主编《吞咽障碍居家康复指导》，副主编《吞咽障碍的评估与治疗》（第一版），先后参与《痉挛的评估与治疗》《康复医学-理论与实践》等10余部专著的编写。
基金资助:
广东省自然科学基金青年提升项目（2023A1515030254）; 广州市科技计划项目（202206010197）

Research progress on application of stem cell and neuromodulation technology in spinal cord injury

ZHANG Cailing^1,2, LAN Yue², MA Yuanhuan¹

1 Guangzhou Institute of Clinical Medicine,Guangzhou First People's Hospital,the Second Affiliated Hospital,South China University of Technology,Guangzhou 510180,China;
2 Department of Rehabilitation Medicine,Guangzhou First People's Hospital,the Second Affiliated Hospital,South China University of Technology,Guangzhou 510180,China

Received:2024-04-09 Online:2024-07-20 Published:2024-08-21

摘要/Abstract

摘要： 脊髓损伤是一种高致残性中枢神经系统疾病,目前缺乏有效的治疗措施。干细胞组织工程兴起和神经调控技术的发展,给脊髓损伤的治疗带来新的希望。目前,多项针对脊髓损伤的干细胞相关治疗项目的临床研究已在全球注册,干细胞疗法是脊髓损伤领域的研究热点,具有良好的应用前景。而神经调控技术一直在临床上脊髓损伤后的康复治疗中发挥着重要作用,特别是靶向神经调控技术近年在脊髓损伤治疗方面取得突破性进展。有研究尝试联合干细胞疗法和神经调控技术应用治疗脊髓损伤,试图取得更好的效果。本文综述了干细胞疗法和神经调控技术在脊髓损伤治疗中的研究进展,旨在探讨其作用效果、修复机制、应用前景以及面临的问题,进一步为脊髓损伤的基础研究和临床转化提供参考。

关键词: 脊髓损伤, 干细胞, 组织工程, 类器官, 神经调控技术, 再生医学

Abstract: Spinal cord injury is a highly disabling disease of the central nervous system without effective treatment to date．With the rise of stem cell and tissue engineering,and the breakthrough of neuromodulation technology,it brings new hope to the treatment of spinal cord injury．At present,a number of clinical studies on stem cell-related treatment projects for spinal cord injury have been registered worldwide,which has become a research hotspot．Neuromodulation technology has been playing an important role in the clinical rehabilitation of spinal cord injury．Especially,breakthroughs have been made in the treatment of spinal cord injury by targeted neuromodulation technology in recent years,which is encouraging．Some studies have attempted to combine stem cell therapy and neuromodulation technology to treat spinal cord injuries in an attempt to achieve better effect．This review summarizes the research progress of stem cell therapy and neuromodulation technology in the treatment of spinal cord injury,with the aim of discussing their effect,repair mechanisms,application prospect and various problems to face,and providing further reference for the basic research and clinical transformation of spinal cord injury．

Key words: spinal cord injury, stem cells, tissue engineering, organoids, neuromodulation technology, regenerative medicine

张彩玲, 兰月, 马瑗锾. 干细胞疗法及神经调控技术在脊髓损伤中的研究进展[J]. 广州医药, 2024, 55(7): 689-704.

ZHANG Cailing, LAN Yue, MA Yuanhuan. Research progress on application of stem cell and neuromodulation technology in spinal cord injury[J]. Guangzhou Medical Journal, 2024, 55(7): 689-704.

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干细胞疗法及神经调控技术在脊髓损伤中的研究进展

Research progress on application of stem cell and neuromodulation technology in spinal cord injury

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