甲状腺乳头状癌碘治疗前短期严重甲减对血脂的影响

doi:10.3969/j.issn.1000-8535.2022.05.009

广州医药 ›› 2022, Vol. 53 ›› Issue (5): 47-52.DOI: 10.3969/j.issn.1000-8535.2022.05.009

甲状腺乳头状癌碘治疗前短期严重甲减对血脂的影响

吴飞鹏¹, 高勇强², 吴琪燕¹, 洪丽菊¹, 程绘珺¹, 李娇霞¹, 周友俊¹, 郑贤东¹

1 昆明医科大学附属延安医院核医学科(昆明 650051)
2 昆明理工大学附属普洱医院核医学科(普洱 665000)

收稿日期:2021-09-23 出版日期:2022-09-20 发布日期:2022-10-11
通讯作者: 郑贤东,E-mail:332863759@qq.com
基金资助:
春城计划“春城名医”专项基金资助项目(C202012021);昆明医科大学研究生创新基金资助项目(2021S265);昆明市卫生健康委员会卫生科研基金资助项目(20200904-111);昆明市卫生科技人才培养基金支持项目(2020SW-24)

Effect of short-term severe hypothyroidism on blood lipids in patients with papillary thyroid carcinoma before iodine therapy

WU Feipeng¹, GAO Yongqiang², WU Qiyan¹, HONG Liju¹, CHENG HuiJun¹, LI Jiaoxia¹, ZHOU Youjun¹, ZHENG Xiandong¹

1 Department of Nuclear Medicine, the Affiliated Yan'an Hospital of Kunming Medical University, Kunming 650051, China
2 Department of Nuclear Medicine, the Affiliated Pu'er Hospital of Kunming University of Science and Technology, Pu'er 665000, China

Received:2021-09-23 Online:2022-09-20 Published:2022-10-11

摘要/Abstract

摘要： 目的探讨甲状腺乳头状癌患者在严重短期甲减的状态下甲状腺功能及相关因素对血脂水平的影响。方法纳入61例通过病理确诊为甲状腺乳头状癌的患者,采集所有患者在手术前与碘治疗前的甲状腺功能水平与血脂水平等资料,比较患者不同性别、年龄、术式、淋巴结转移情况等相关因素对血脂的影响。结果碘治疗前的全部血脂指标均高于手术前的基线水平;在促甲状腺激素 (TSH)>60 mIU/L组中的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(APO-A1)、载脂蛋白B(APO-B)、脂蛋白(LP)水平明显高于TSH≤60 mIU/L组;女性患者的甘油三酯(TG)、动脉硬化指数(AI)水平明显低于男性患者,男性组的HDL-C、APO-A1水平低于女性组,年龄>45岁的患者TC水平高于年龄≤45岁的患者,差异均有统计学意义(P均＜0.05);不同术式及淋巴结转移分组间的血脂水平未见明显差异(P＞0.05);TC水平与游离三碘甲状原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺素(T4)水平呈负相关(r分别为-0.342、-0.370、-0.340),HDL-C、LDL-C及APO-B水平与T4水平呈负相关(r分别为-0.294、-0.354、-0.324),APO-A1水平与FT4、三碘甲状腺原氨酸(T3)、T4水平呈负相关(r分别为-0.306、-0.262、-0.263),LPa水平与T3、T4水平呈负相关(r分别为-0.268、-0.313)。结论甲状腺乳头状癌碘治疗前短期甲减可以导致全套血脂指标升高,在此甲减状态下程度越严重的甲减可产生越高的血脂水平,同时男性患者与中老年患者也可伴随更高的血脂水平。

关键词: 甲状腺激素, 胆固醇, 甲状腺乳头状癌

Abstract: Objectives To investigate the influence of thyroid function and related factors on blood lipid levels in patients with papillary thyroid cancer under short-term severe hypothyroidism. Methods Sixty-one patients with papillary thyroid carcinoma diagnosed by pathology were included. The data of thyroid function and blood lipid levels of all patients before operation and iodine treatment were collected. The effects of gender, age, operation mode, lymph node metastasis and other related factors on blood lipid were compared. Results Before iodine treatment, all blood lipid indexes were higher than the baseline level before operation. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (APO-A1), apolipoprotein B (APO-B), lipoproteins (LP) in the thyroid stimulating hormone (TSH)>60 mIU/L group were significantly higher than those in the TSH≤60 mIU/L group.Triglyceride (TG) and arteriosclerosis index (AI) levels were significantly lower in female patients compared with male patients, HDL-C and APO-A1 levels were lower in male patients compared with female patients, and TC levels were higher in patients aged>45 compared with those aged≤45, with significant differences (all P<0.05). No significant differences were observed in lipid levels among the different surgical procedures and lymph node metastasis subgroups (P>0.05). TC levels were negatively correlated with free triiodothyronines (FT3), free thyroxine (FT4), thyroxine (T4) levels (r=-0.342,-0.370,-0.340,respectively). HDL-C, LDL-C, and APO-B levels were negatively correlated with T4 levels (r=-0.294, -0.354, -0.324,respectively), APO-A1 levels were negatively correlated with FT4, triiodothyronine (T3), T4 levels (r=-0.306,-0.262,-0.263,respectively), and LP levels were negatively correlated with T3 and T4 levels (r=-0.268,-0.313, respectively). Conclusions Short term hypothyroidism before iodine treatment for papillary thyroid cancer could lead to the increase of full set of blood lipid indexes, male patients and middle-aged and elderly patients could also be accompanied by higher blood lipid levels.

Key words: thyroid hormone, cholesterol, papillary thyroid carcinoma

吴飞鹏, 高勇强, 吴琪燕, 洪丽菊, 程绘珺, 李娇霞, 周友俊, 郑贤东. 甲状腺乳头状癌碘治疗前短期严重甲减对血脂的影响[J]. 广州医药, 2022, 53(5): 47-52.

WU Feipeng, GAO Yongqiang, WU Qiyan, HONG Liju, CHENG HuiJun, LI Jiaoxia, ZHOU Youjun, ZHENG Xiandong. Effect of short-term severe hypothyroidism on blood lipids in patients with papillary thyroid carcinoma before iodine therapy[J]. Guangzhou Medical Journal, 2022, 53(5): 47-52.

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甲状腺乳头状癌碘治疗前短期严重甲减对血脂的影响

Effect of short-term severe hypothyroidism on blood lipids in patients with papillary thyroid carcinoma before iodine therapy

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