CD28和PD-1在自发性脑出血预后中的研究进展

doi:10.20223/j.cnki.1000-8535.2025.04.003

摘要/Abstract

摘要： 自发性脑出血（SICH）是脑卒中的一种常见形式,其预后通常较差,因此早期评估和调节患者出血后的免疫状态至关重要。免疫检查点是评估T淋巴细胞活跃性和增殖状态的关键指标,监测这些检查点有助于预测脑出血患者的预后。程序性死亡蛋白1（PD-1）和细胞分化抗原28（CD28）作为两个典型的免疫检查点,它们在脑出血预后评估中的应用正逐渐成为研究的热点。该文综述了脑出血后机体免疫状态的变化,以及PD-1和CD28在脑出血后评估和治疗中的研究进展。

关键词: 自发性脑出血, 免疫检查点, PD-1, CD28, 脑出血后免疫抑制

Abstract: Spontaneous intracerebral hemorrhage（SICH）is a common cause of stroke,with specific outcomes often being poor．Therefore,early assessment and modulation of the immune status after hemorrhage are of critical importance．Immune checkpoints serve as key indicators for assessing the activation and proliferation of T cells,and monitoring these checkpoints can help to predict the outcomes of patients with intracerebral hemorrhage．PD-1（programmed death 1）and CD28（Cluster of Differentiation 28）are two representative immune checkpoints,and their use in prognostic assessment after intracerebral hemorrhage is becoming a focus of research．This article reviews the changes in the immune state of the body after intracerebral hemorrhage,as well as the research progress on the use of PD-1 and CD28 in the evaluation and treatment following intracerebral hemorrhage．

Key words: spontaneous intracerebral hemorrhage, immune checkpoint, PD-1, CD28, immune suppression after intracerebral hemorrhage

沈俊杰, 蔡勇, 钟兴明. CD28和PD-1在自发性脑出血预后中的研究进展[J]. 广州医药, 2025, 56(4): 446-451.

SHEN Junjie, CAI Yong, ZHONG Xingming. Research progress of CD28 and PD-1 in the prognosis of spontaneous intracerebral hemorrhage[J]. Guangzhou Medical Journal, 2025, 56(4): 446-451.

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