大蒜对糖脂代谢调节作用的研究进展

doi:10.3969/j.issn.1000-8535.2024.05.004

广州医药 ›› 2024, Vol. 55 ›› Issue (5): 472-477.DOI: 10.3969/j.issn.1000-8535.2024.05.004

大蒜对糖脂代谢调节作用的研究进展

张瑞祥^1,2, 何志伟^1,2, 韦晓^1,2, 刘超^1,2

1 南京中医药大学附属中西医结合医院内分泌科（江苏南京 210028）
2 江苏省中医药研究院（江苏南京 210028）

收稿日期:2023-08-13 出版日期:2024-05-20 发布日期:2024-06-28
通讯作者: 韦晓,E-mail：weixiaosci@foxmail.com;刘超,E-mail：liuchao@nfmcn.com

Garlic and its regulatory effects on glucose and lipid metabolism

ZHANG Ruixiang^1,2, HE Zhiwei^1,2, WEI Xiao^1,2, LIU Chao^1,2

1 Department of Endocrinology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China
2 Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China

Received:2023-08-13 Online:2024-05-20 Published:2024-06-28

摘要/Abstract

摘要： 大蒜为百合科葱属植物的地下鳞茎,具有药食两用的价值,其含有大蒜素、二烯丙基硫醚、二烯丙基二硫醚、二烯丙基三硫醚、硫-烯丙基半胱氨酸等多种生物活性成分,具有抗氧化、抗感染、免疫调节、心血管保护、抗癌等作用。不仅如此,大蒜在糖脂代谢的调节中功效显著,且相关机制日益明晰,主要包括保护胰岛β细胞功能、改善胰岛素抵抗、阻止脂肪细胞生长、抑制脂合成代谢及调节肠道菌群分布等。不同的提取工艺可影响大蒜的功效,其提取手段及药效关系值得进一步研究。

关键词: 大蒜, 糖代谢, 脂代谢, 分子机制

Abstract: Garlic has values of both medicine and food,with rich allicin,diallyl disulfide（DADS）,diallyl trisulfide（DATS）and other garlic sulfur contents,which have been found to have multiple effets such as antioxidant,anti-infection,immunomodulatory,cardiovascular protection,anti-cancer,etc．Moreover,numerous studies have demonstrated that garlic plays an important role in the regulation of glycose and lipid metabolism,and the relevant mechanisms are becoming better understood,including protecting pancreatic β cells,improving insulin resistance,preventing the growth of fat cells,inhibiting lipid anabolism and adjusting the distribution of intestinal microflora．Different extraction processes can affect the efficacy of garlic,and further investigations are needed to elucidate the relationship between effective extraction methods and pharmacodynamic properties．

Key words: garlic, glucose metabolism, lipid metabolism, molecular mechanism

张瑞祥, 何志伟, 韦晓, 刘超. 大蒜对糖脂代谢调节作用的研究进展[J]. 广州医药, 2024, 55(5): 472-477.

ZHANG Ruixiang, HE Zhiwei, WEI Xiao, LIU Chao. Garlic and its regulatory effects on glucose and lipid metabolism[J]. Guangzhou Medical Journal, 2024, 55(5): 472-477.

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大蒜对糖脂代谢调节作用的研究进展

Garlic and its regulatory effects on glucose and lipid metabolism

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