靳三针联合多奈哌齐治疗卒中后认知障碍的研究观察

doi:10.3969/j.issn.1000-8535.2022.02.005

广州医药 ›› 2022, Vol. 53 ›› Issue (2): 23-26.DOI: 10.3969/j.issn.1000-8535.2022.02.005

靳三针联合多奈哌齐治疗卒中后认知障碍的研究观察

唐梁¹, 陈志宁¹, 梁伟海¹, 刘晓俊¹, 欧阳樱君²

1 广州市第一人民医院中医科(广州 510180)
2 广州市第一人民医院神经内科 (广州 510180)

收稿日期:2021-05-13 发布日期:2022-04-12
通讯作者: 刘晓俊,E-mail:alxj@163.com
基金资助:
广东省中医药局科研项目(20191266);广州市科技计划项目(202102080672);刘晓俊广州市名中医传承工作室建设项目(ky01050002)

Observation of Jin's three-needle therapy combined with donepezil in the treatment of post-stroke cognitive impairment

TANG Liang¹, CHEN Zhining¹, LIANG Weihai¹, LIU Xiaojun ¹, OUYANG Yingjun²

1 Department of Traditional Chinese Medicine, Guangzhou First People's Hospital,Guangzhou 510180,China
2 Department of Neurology, Guangzhou First People's Hospital,Guangzhou 510180,China

Received:2021-05-13 Published:2022-04-12

摘要/Abstract

摘要： 目的观察靳三针治疗卒中后认知功能障碍(PSCI)的临床疗效。方法选取广州市第一人民医院南沙医院中医科、神经内科、精神科卒中后出现认知功能障碍的患者60 例,随机分为治疗1组,治疗2组和对照组,每组20例。对照组予盐酸多奈哌齐片口服,治疗1组予靳三针治疗,治疗2组予多奈哌齐口服及靳三针治疗。各组均在治疗前、治疗12周进行中医症候临床疗效评定和精神状态简易量表(MMSE)评定。结果 MMSE疗效评定中,治疗1组和对照组总有效率相当,治疗2组治疗有效率高于对照组及治疗1组。中医症候疗效评定中,治疗2组愈显率高于对照组及治疗1组,治疗2组愈显率较治疗1组明显升高,对比差异有统计学意义(P<0.05)。对照组、治疗1组、治疗2组经过12周治疗后MMSE评分较前升高,治疗前后比较差异均有统计学意义(P<0.05)。3组中风病诊断与疗效评定评分治疗后有所下降,治疗前后比较差异有统计学意义(P<0.05)。治疗2组与对照组、治疗1组对比,2组对比差异均有统计学意义(P<0.05)。结论靳三针联合多奈哌齐治疗PSCI效果明显,针刺与药物结合应用治疗更有利于PSCI的恢复。

关键词: 卒中后认知障碍, 靳三针, 多奈哌齐

Abstract: Objective To observe the clinical effect of Jin's three-needle therapy on post-stroke cognitive impairment (PSCI). Methods A total of 60 patients with cognitive dysfunction after stroke in the department of traditional Chinese medicine (TCM), department of neurology and department of psychiatry in Nansha Hospital of Guangzhou First People's Hospital were randomly divided into treatment group 1, treatment group 2 and control group, 20 cases in each group.The control group was given donepezil hydrochloride orally, the treatment group 1 was given Jin's three-needle therapy, the treatment group 2 was given donepezil oral therapy and Jin's three-needle therapy.All groups were assessed with mini-mental state examination (MMSE) before and 12 weeks after treatment. Results In MMSE, the total effective rate of treatment group 1 was similar to that of control group, and the effective rate of treatment group 2 was higher than that of control group and treatment group 1.In the evaluation of TCM symptom curative effect, the cure rate of the group 2 was higher than that of the control group and the group 1.The effective rate of group 2 was significantly higher than that of group 1 (P< 0.05). After 12 weeks of treatment, MMSE scores in control group, group 1 and group 2 were significantly higher than those before treatment (P< 0.05). The score of diagnosis and curative effect of stroke in three groups decreased after treatment, and the difference was statistically significant (P<0.05). There were significant differences between control group, group 1 and group 2 (P< 0.05). Conclusion Jin's three-needle therapy combined with donepezil is effective in the treatment of PSCI.Acupuncture combined with medicine is more beneficial to the recovery of PSCI.

Key words: post-stroke cognitive impairment, Jin's three-needle therapy, donepezil

唐梁, 陈志宁, 梁伟海, 刘晓俊, 欧阳樱君. 靳三针联合多奈哌齐治疗卒中后认知障碍的研究观察[J]. 广州医药, 2022, 53(2): 23-26.

TANG Liang, CHEN Zhining, LIANG Weihai, LIU Xiaojun , OUYANG Yingjun. Observation of Jin's three-needle therapy combined with donepezil in the treatment of post-stroke cognitive impairment[J]. Guangzhou Medical Journal, 2022, 53(2): 23-26.

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靳三针联合多奈哌齐治疗卒中后认知障碍的研究观察

Observation of Jin's three-needle therapy combined with donepezil in the treatment of post-stroke cognitive impairment

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