微泡超声空化在增强微波消融对肝脏肿瘤的热消融效应中的价值

doi:10.3969/j.issn.1000-8535.2021.01.009

广州医药 ›› 2021, Vol. 52 ›› Issue (1): 43-48.DOI: 10.3969/j.issn.1000-8535.2021.01.009

微泡超声空化在增强微波消融对肝脏肿瘤的热消融效应中的价值

胡志文^1,2, 萧淑宜¹, 格桑卓玛², 金海¹, 董燕¹, 柳建华¹

1 广州市第一人民医院超声医学科(广州 510180)
2 林芝市人民医院功能科(林芝 860000)

收稿日期:2020-08-13 出版日期:2021-01-20 发布日期:2021-11-22
通讯作者: 柳建华,E-mail:eyliujianhua@scut.edu.cn

Valuable study of microbubble ultrasound cavitation enhanced microwave ablation for liver cancer

HU Zhiwen^1,2, XIAO Shuyi¹, GESANG Zhuoma², JIN Hai¹, DONG Yan¹, LIU Jianhua¹

1 Department of Medical Ultrasound,Guangzhou First People's Hospital,Guangzhou 510180, China
2 Function Department,Linzhi People's Hospital,Linzhi 860000, China

Received:2020-08-13 Online:2021-01-20 Published:2021-11-22

摘要/Abstract

摘要： 目的通过研究微泡超声空化增强微波消融对兔VX2肿瘤的热消融效应来探究其在肿瘤治疗中的价值。方法 24只肝脏移植瘤兔随机分为空白对照组、单纯超声空化治疗组、单纯微波消融治疗组、超声空化联合微波消融治疗组4组。利用增强超声显示每组治疗前后肿瘤的大小、形状和轮廓并通过温度针来检测治疗区域的局部温度。结果联合治疗组血流灌注缺损最严重,微波消融组和联合治疗组缺损体积分别为1.53±0.20和1.68±0.43(P=0.117);微波消融组以及联合治疗组消融治疗时温度达平台时间分别为(21.7±5.0)s和(10.3±5.0)s(P<0.01),最高温度(℃)分别为100.9±5.0和134.1±6.0(P<0.01)。结论 MWA联合MEUS治疗肝癌可使治疗区局部温度急剧升高至峰值温度,有望提高肝癌治疗效果。

关键词: 微泡超声空化, 微波消融, 肝癌, 治疗

Abstract: Objective To investigate the thermal ablation effect of microbubble ultrasound cavitation combined with microwave ablation on rabbit VX2 tumors. Methods Twenty-four rabbits with liver transplantation tumors were randomly divided into four groups: blank control group, ultrasound-only cavitation treatment group, microwave-only ablation treatment group, and ultrasound-cavitation combined with microwave ablation treatment group. Enhanced ultrasound was used to show the size, shape and contour of the tumor before and after treatment in each group, and the local temperature of the treatment area was detected by a temperature needle. Results The blood flow perfusion defect was the most severe in the combined treatment group. The defect volume of the microwave ablation group and the combined treatment group were 1.53±0.20 and 1.68±0.43 (P=0.117). The temperature reached the plateau time in the microwave ablation group and the combined treatment group. It was (21.7±5.0)s and (10.3±5.0)s (P<0.01), and the highest temperature (℃) was 100.9±5.0 and 134.1±6.0 (P<0.01). Conclusion MWA combined with MEUS for liver cancer can sharply increase the local temperature in the treatment area to the peak temperature, which is expected to improve the treatment effect of liver cancer.

Key words: Microbubble ultrasound cavitation, Microwave ablation, Liver cancer, Treatment

胡志文, 萧淑宜, 格桑卓玛, 金海, 董燕, 柳建华. 微泡超声空化在增强微波消融对肝脏肿瘤的热消融效应中的价值[J]. 广州医药, 2021, 52(1): 43-48.

HU Zhiwen, XIAO Shuyi, GESANG Zhuoma, JIN Hai, DONG Yan, LIU Jianhua. Valuable study of microbubble ultrasound cavitation enhanced microwave ablation for liver cancer[J]. Guangzhou Medical Journal, 2021, 52(1): 43-48.

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微泡超声空化在增强微波消融对肝脏肿瘤的热消融效应中的价值

Valuable study of microbubble ultrasound cavitation enhanced microwave ablation for liver cancer

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