四金石灵膏配合间苯三酚治疗输尿管结石伴肾绞痛的疗效观察

doi:10.3969/j.issn.1000-8535.2020.06.011

广州医药 ›› 2020, Vol. 51 ›› Issue (6): 53-56.DOI: 10.3969/j.issn.1000-8535.2020.06.011

四金石灵膏配合间苯三酚治疗输尿管结石伴肾绞痛的疗效观察

张海¹, 肖勇辉¹, 王晓民², 邓汪东²

1 梅州市中医医院药学部(梅州 514000)
2 梅州市中医医院二外科(梅州 514000)

收稿日期:2020-02-27 出版日期:2020-11-20 发布日期:2021-11-28

Analysis of curative effect of four-gold-stone-ling confection combined with phloroglucinol in the treatment of ureteral calculus with renal colic

ZHANG Hai¹, XIAO Yonghui¹, WANG Xiaoming², DENG Wangdong²

1 Department of Pharmacy,Meizhou Hospital of Traditional Chinese Medicine, Meizhou 514000,China
2 The Second Surgery Department,Meizhou Hospital of Traditional Chinese Medicine, Meizhou 514000, China

Received:2020-02-27 Online:2020-11-20 Published:2021-11-28

摘要/Abstract

摘要： 目的探讨四金石灵膏联合间苯三酚治疗输尿管结石伴肾绞痛的应用价值。方法随机将76例输尿管结石伴肾绞痛患者分为两组,以接受中药安慰剂联合间苯三酚治疗者为对照组,以接受四金石灵膏联合间苯三酚治疗者为观察组,每组38例。对比两组临床治疗效果,并分析尿液相关指标的变化情况。结果两组7 d治疗过程中VAS评分及尿Ga水平呈降低趋势、WHOQL-BREF评分及尿OPN水平呈升高趋势(P<0.05),而治疗3 d及7 d后,治疗组VAS评分及尿Ga水平低于对照组、WHOQL-BREF评分及尿OPN水平高于对照组(P<0.05)。同时,治疗7 d后,观察组排石率高于对照组(P<0.05),而观察组排石时间及止痛时间短于对照组(P<0.05)。此外,治疗7 d后,治疗组治疗总有效率高于对照组(P<0.05),而两组间治疗不良反应发生率比较未见差异有统计学意义(P>0.05)。结论四金石灵膏联合间苯三酚可有效的提高输尿管结石伴肾绞痛的临床治疗效果,具有较为理想的应用价值。

关键词: 四金石灵膏, 间苯三酚, 输尿管结石, 肾绞痛

Abstract: Objective To explore the application value of four-gold-stone-ling confection and phloroglucinol in the treatment of ureteral calculus with renal colic. Methods 76 patients with ureteral calculus with renal colic were randomly divided into two groups, with those receiving traditional Chinese medicine placebo combined with phloroglucinol as the control group, and those receiving four-gold-stone-ling confection combined with phloroglucinol as the observation group,38 cases in each group. The clinical treatment effects of the two groups were compared, and the changes of urine-related indicators were analyzed. Results The VAS score and urine Ga level of the two groups showed a decreasing trend during 7d treatment, and the WHOQL-BREF score and urine OPN level showed an increasing trend(P<0.05). After 3d and 7d treatment, the VAS score and urine Ga level of the treatment group were lower than that of control group, the WHOQL-BREF score and urine OPN level were higher than that of control group(P<0.05). Meanwhile, After 7d of treatment, the rate of stone drainage in the observation group was higher than that of control group(P<0.05), while the time of stone drainage and pain relief in the observation group was shorter than control group(P<0.05). In addition, after 7d treatment, the total effective rate of the treatment group was higher than control group (P<0.05), while the difference of incidence of adverse reactions between the two groups was not significant(P>0.05). Conclusion Four-gold-stone-ling confection combined with phloroglucinol may effectively improve the clinical effect of ureteral calculi with renal colic, and have ideal application value.

Key words: Four-gold-stone-ling confection, Phloroglucinol, Ureteral calculus, Renal colic

张海, 肖勇辉, 王晓民, 邓汪东. 四金石灵膏配合间苯三酚治疗输尿管结石伴肾绞痛的疗效观察[J]. 广州医药, 2020, 51(6): 53-56.

ZHANG Hai, XIAO Yonghui, WANG Xiaoming, DENG Wangdong. Analysis of curative effect of four-gold-stone-ling confection combined with phloroglucinol in the treatment of ureteral calculus with renal colic[J]. Guangzhou Medical Journal, 2020, 51(6): 53-56.

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四金石灵膏配合间苯三酚治疗输尿管结石伴肾绞痛的疗效观察

Analysis of curative effect of four-gold-stone-ling confection combined with phloroglucinol in the treatment of ureteral calculus with renal colic

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