30岁及以下乳腺癌术后首次复发转移特点分析

doi:10.3969/j.issn.1000-8535.2020.01.012

广州医药 ›› 2020, Vol. 51 ›› Issue (1): 50-54.DOI: 10.3969/j.issn.1000-8535.2020.01.012

30岁及以下乳腺癌术后首次复发转移特点分析

王秋明, 李亮, 张锦丰, 吴静娜

梅州市人民医院化疗科 (梅州 514031)

收稿日期:2019-07-24 出版日期:2020-01-20 发布日期:2021-11-28
通讯作者: 王秋明,E-mail: wangqiuming168@163.com
基金资助:
梅州市医药卫生项目(编号:2016-B-33)

Analysis of the first recurrent pattern after radical surgery in breast cancer aged 30 years and younger

WANG Qiuming, LI Liang, ZHANG Jinfeng, WU Jingna

Department of Chemotherapy,Meizhou People's Hospital, Meizhou 514031,China

Received:2019-07-24 Online:2020-01-20 Published:2021-11-28

摘要/Abstract

摘要： 目的探讨分析30岁及以下青年乳腺癌患者术后首次复发转移特点,以期指导术后随访,早期发现转移病灶。方法回顾性分析2003年1月—2018年8月在梅州市人民医院收治的年龄≤30岁乳腺癌患者73例,所有患者均行根治性手术治疗,分析临床病理特点及术后首次复发转移特点。结果共纳入23例三阴性(31.5%)、20例luminal B(HER2-)型(27.4%)、12例HER-2阳性型(16.4%)、10例 Luminal B(HER2+)型(13.7%)、4例Luminal A型(5.5%)和4例分型不明(5.5%)。中位随访28.4个月,7例三阴性(7/23, 30.4%)、 6例HER-2阳性型(6/12, 50.0%)、 4例Luminal B(HER2-)型(4/20, 20.0%) 和3例 Luminal B(HER2+)型(3/10, 30.0%)出现复发转移。复发转移患者中,90.0%合并远处转移,75.0%合并内脏转移,其中HER-2阳性型均合并内脏转移;92.3%(12/13)激素受体阴性患者复发转移发生在术后2年内。三阴性患者最常见远处转移部位是远处淋巴结,HER-2阳性型患者最常见远处转移部位是肝,luminal B(HER2+)型患者最常见远处转移部位是肺和骨,luminal B(HER2-)型患者最常见远处转移部位是肺和远处淋巴结。结论 ≤30岁青年乳腺癌患者术后首次复发转移多合并远处转移,激素受体阴性患者容易早期复发,不同分子分型患者具有不同的好发远处转移部位。

关键词: 青年, 乳腺恶性肿瘤, 肿瘤转移

Abstract: Objective We retrospectively investigated the first recurrent pattern after radical surgery in breast cancer patients aged ≤30 years, so as to guide postoperative follow-up and early detection of recurrent lesions. Methods A total of 73 consecutive early breast cancer patients aged ≤30years admitted to Meizhou People's Hospital from January 2003 to August 2018 were included. Retrospective analysis was conducted to analyze the clinicpathologic characteristics and characteristics of first recurrent pattern. Results 23 triple negative(31.5%), 20 Luminal B(27.4%), 12 HER2 enriched (16.4%), 10 Luminal/HER2+(13.7%), 4 Luminal A(5.5%) and 4 undifined subtypes(5.5%) were included. After a median follow-up of 28.4 months, 20 patients relapsed, which included 7 triple-negative(7/23, 30.4%), 6 HER2-enriched (6/12, 50.0%), 4 luminal B(4/20, 20.0%) and 3 luminal/HER2+(3/10, 30.0%) subtypes. 90.0% of patients combined with distant metastasis. 75.0% of patients had visceral metastasis, which included all the recurrent HER-2 enriched patients. 92.3% of hormone receptor negative(HR-) patients had a RFS less than 2 years. The most common metastatic sites in triple-negative, HER-2-enriched, luminal/HER2+ and luminal B subtypes were distant nodes, liver, lung and bone, distant nodes and lung, respectively. Conclusion The first recurrent pattern mainly presented as distant metastasis in breast cancer patients aged≤30 years, with early relapse in patients with HR- diseases. Different molecular subtypes of breast cancer favor different distant metastatic sites.

Key words: Young patients, Breast Neoplasms, Neoplasm Metastasis

王秋明, 李亮, 张锦丰, 吴静娜. 30岁及以下乳腺癌术后首次复发转移特点分析[J]. 广州医药, 2020, 51(1): 50-54.

WANG Qiuming, LI Liang, ZHANG Jinfeng, WU Jingna. Analysis of the first recurrent pattern after radical surgery in breast cancer aged 30 years and younger[J]. Guangzhou Medical Journal, 2020, 51(1): 50-54.

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30岁及以下乳腺癌术后首次复发转移特点分析

Analysis of the first recurrent pattern after radical surgery in breast cancer aged 30 years and younger

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