平胃散联合耳穴对单纯性肥胖的临床疗效及对血清NPY和Leptin的影响

doi:10.3969/j.issn.1000-8535.2018.03.005

广州医药 ›› 2018, Vol. 49 ›› Issue (3): 19-22.DOI: 10.3969/j.issn.1000-8535.2018.03.005

平胃散联合耳穴对单纯性肥胖的临床疗效及对血清NPY和Leptin的影响

邓聪^1,2, 张艳红¹, 岑美婷¹, 蔡敬宙¹, 赖艳娴¹, 杨志敏²

1 广州市第一人民医院南沙医院 (广州 511457)
2 广州中医药大学第二临床医学院(广州 510120)

收稿日期:2018-01-25 出版日期:2018-05-20 发布日期:2021-12-01
基金资助:
广州市第三批优秀中医临床人才研修项目(NO.GZYC03201602)

Effects of Pingwei Powder combined with auricular point therapy on serum levels of NPY and leptin in simple obesity patients

DENG Cong^1,2, ZHANG Yanhong¹, CEN Meiting¹, CAI Jingzhou², LAI Yanxian¹, YANG Zhimin²

1 Nansha Hospital of Guangzhou First Peoole's Hospital, Guangzhou 511457, China
2 The Second Clinical College of Guangzhou University of Chinese Medcine,Guangzhou 510120, China

Received:2018-01-25 Online:2018-05-20 Published:2021-12-01

摘要/Abstract

摘要： 目的观察平胃散联合耳穴治疗单纯性肥胖的临床疗效及其对血清神经肽Y(Neuropeptide Y,NPY)和瘦素(Leptin,LP)水平的影响。方法 64例单纯性肥胖患者,采用数字表法随机分为治疗组33例和对照组31例。治疗组予口服平胃散免煎颗粒配合耳穴治疗,对照组予口服奥利司他胶囊治疗,疗程4周。观察治疗前后体质量、体质量指数(bodymass index,BMI)、体脂百分比(Fat%,F%)、腰臀比(Waist Hip Ratio,WHR)、NPY、LP的变化。结果治疗后,治疗组和对照组体质量、BMI、F%、WHR、相关疾病的危险度均下降(P＜0.001)。比较治疗前后体质量、BMI、F%、WHR差值,治疗组下降均比对照组明显(P＜0.01、P＜0.001)。治疗组临床疗效优于对照组(P＜0.05)。治疗组和对照组血清NPY、LP水平均下降(P＜0.001),且治疗组较对照组下降(P＜0.001)。结论平胃散联合耳穴有较好的减肥作用,其机制可能是通过降低血清中NPY、LP含量。

关键词: 单纯性肥胖, 平胃散, 耳穴, 神经肽Y, 瘦素

Abstract: Objective Clinical observation of Pingwei Powder combined with auricular point therapy in treating simple obesity and the effect on serum NPY and leptin Levels. Methods 64 cases of simple obesity patients were randomized into treatment group(33 cases) and control group(31 cases). The treatment group was given Pingwei Powder combined with auricular point therapy.The control group was given Orlistat capsules. After being treated for 4 weeks, body weight, bodymass index(BMI), fat% (F%), waist hip ratio (WHR),neuropeptide y (NPY) and leptin(LP) were determined. Results After post-treatment in treatment group and control group, body weight, BMI, F%, WHR, the risk of related diseases all decreased (P＜0.001), The body weight, BMI, F%, WHR before and after treatment were lower than those in the control group(P＜0.01, P＜0.001). The clinical efficacy of the treatment group was better than that of the control group(P＜0.05). Serum NPY and LP levels in treatment group and control group were decreased (P＜0.001), and that the treatment group were lower than of the control group (P＜0.001). Conclusion Pingwei Powder combined with auricular point therapy have better in weight loss, which is possibly by way of reducing serum NPY, LP Levels.

Key words: Simple Obesity, Pingwei Powder, Auricular Point Therapy, Neuropeptide Y, Leptin

邓聪, 张艳红, 岑美婷, 蔡敬宙, 赖艳娴, 杨志敏. 平胃散联合耳穴对单纯性肥胖的临床疗效及对血清NPY和Leptin的影响[J]. 广州医药, 2018, 49(3): 19-22.

DENG Cong, ZHANG Yanhong, CEN Meiting, CAI Jingzhou, LAI Yanxian, YANG Zhimin. Effects of Pingwei Powder combined with auricular point therapy on serum levels of NPY and leptin in simple obesity patients[J]. Guangzhou Medical Journal, 2018, 49(3): 19-22.

平胃散联合耳穴对单纯性肥胖的临床疗效及对血清NPY和Leptin的影响

Effects of Pingwei Powder combined with auricular point therapy on serum levels of NPY and leptin in simple obesity patients

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