ACE2基因多态性与儿童激素敏感型肾病综合征复发的关系

doi:10.3969/j.issn.1000-8535.2018.02.002

广州医药 ›› 2018, Vol. 49 ›› Issue (2): 6-9.DOI: 10.3969/j.issn.1000-8535.2018.02.002

ACE2基因多态性与儿童激素敏感型肾病综合征复发的关系

邱明瑜, 于力, 王丽娜

广州市第一人民医院儿科(广州 510180)

收稿日期:2017-12-12 出版日期:2018-03-20 发布日期:2021-12-01
通讯作者: 于力,E-mail:yuli828@yeah.net
基金资助:
广州市医药卫生科技项目(20151A011008)

Association between ACE2 gene polymorphism and relapse in childhood with steroid-sensitive nephrotic syndrom

QIU Mingyu, YU Li, WANG Lina

Department of Pediatrics, Guangzhou First People's Hospital, Guangzhou 510180, China

Received:2017-12-12 Online:2018-03-20 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨广东汉族儿童ACE2基因A9570G多态性与儿童激素敏感型肾病综合征(SSNS)复发的关系。方法选取广东汉族SSNS患儿92例,按发病后1年复发情况分为频复发组31例、非频复发组61例,健康体检者60例为对照组,采用聚合酶链反应-DNA直接测序技术观察患儿与对照组ACE2基因A9570G基因型分布和等位基因频率。结果在女性,SSNS组G等位基因频率及GG基因型分布均低于对照组(39％ vs 65％,P<0.05;27％ vs 50％,P<0.05);在男性,SSNS组G等位基因/GG基因型分布亦低于对照组(35％ vs 60％,P<0.05 )。亚组分析发现,在女性,频复发组G 等位基因频率及GG 基因型分布均高于非频复发组(58％ vs 29％,P<0.05;42％ vs 19％,P<0.05);在男性,频复发G基因型/G等位基因频率高于非频复发(58％ vs 24％,P<0.05)。结论 ACE2基因A9570G多态性与儿童SSNS复发相关,携带G等位基因的患儿容易表现为频复发。

关键词: 激素敏感型肾病综合征, 血管紧张素转换酶2, 基因多态性

Abstract: Objective To investigate the association between the A9570G polymorphism of ACE2 gene and the relapse of steroid-sensitive nephrotic syndrome (SSNS) in Han childhood of Guangdong.Methods Ninety-two children with SSNS were selected from Guangdong Han nationality. According to the relapse frequency during the first year of the disease, 31 cases with more than 3 relapses were as frequency relapse group, 61 cases with less than 3 relapses were as non-frequent relapse group, and 60 healthy children were as control group. The gene distribution and allele frequency of ACE2 gene A9570G were observed by polymerase chain reaction-DNA direct sequencing technology.Results In female,the distribution of G allele frequency and GG genotype in SSNS group were significantly lower than that in the control group(39％ vs 65％, P<0.05; 27％ vs 50％, P<0.05). In male, the distribution of G allele/GG genotype in SSNS group was also significantly lower than that in the control group(35% vs 60%, P<0.05). Subgroup analysis found that the distribution of G allele frequency and GG genotype in female of the frequency relapse group were significantly higher than that of the non-frequency relapse group(58% vs 29%, P<0.05; 42% vs 19%, P<0.05), and the distribution of G allele/GG genotype in male of the frequency relapse group was significantly higher than that of the non-frequency relapse group (58% vs 24%, P<0.05).Conclusion The A9570G polymorphism of ACE2 gene was associated with the recurrence of children's SSNS, and the children with G allele were susceptible to recurrence.

Key words: Steroid-sensitive nephrotic syndrome, Angiotensin converting enzyme 2, Gene polymorphism

邱明瑜, 于力, 王丽娜. ACE2基因多态性与儿童激素敏感型肾病综合征复发的关系[J]. 广州医药, 2018, 49(2): 6-9.

QIU Mingyu, YU Li, WANG Lina. Association between ACE2 gene polymorphism and relapse in childhood with steroid-sensitive nephrotic syndrom[J]. Guangzhou Medical Journal, 2018, 49(2): 6-9.

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ACE2基因多态性与儿童激素敏感型肾病综合征复发的关系

Association between ACE2 gene polymorphism and relapse in childhood with steroid-sensitive nephrotic syndrom

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