系统性红斑狼疮患者血清维生素D和白介素-17水平变化及其临床意义

doi:10.3969/j.issn.1000-8535.2017.03.003

广州医药 ›› 2017, Vol. 48 ›› Issue (3): 12-16.DOI: 10.3969/j.issn.1000-8535.2017.03.003

系统性红斑狼疮患者血清维生素D和白介素-17水平变化及其临床意义

唐莼, 林小军, 余纳, 叶静华, 李伟念, 何志翔, 李芳菲, 蔡小燕

广州市第一人民医院风湿免疫内科(广州 510180)

收稿日期:2017-01-12 发布日期:2021-12-01
通讯作者: 蔡小燕, E-mail: xycai@medmail.com.cn
基金资助:
广州市科技计划项目(201607010145)

Clinical significance of changes on serum levels of vitamin D and interleukin-17 in patients with systemic lupus erythematosus

TANG Chun, LIN Xiaojun, YU Na, YE Jinghua, LI Weinian, HE Zhixiang, LI Fangfei, CAI Xiaoyan

Department of Rheumatology ＆ Immunology, Guangzhou First People's Hospital, Guangzhou 510180, China

Received:2017-01-12 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨系统性红斑狼疮(SLE)患者外周血中25-羟基维生素D(25-OH-D)和白介素-17(IL-17)水平的变化及其临床意义。方法选取40例SLE患者作为研究对象, 20例健康体检人员为健康对照组。运用电化学发光法检测25-OH-D水平,酶联免疫吸附法检测IL-17水平。结果 SLE患者25-OH-D水平明显低于健康对照组(P<0.01),活动期SLE患者25-OH-D水平明显低于缓解期患者(P<0.01)。SLE患者IL-17水平明显升高(P<0.01)。低25-OH-D水平与肾损害(P<0.01)相关,与疾病活动度评分(SLEDAI评分)(r=-0.844,P<0.01)及IL-17水平(r=-0.596,P<0.01)负相关。结论 SLE患者25-OH-D水平降低,低25-OH-D水平与肾损害、病情活动及高IL-17水平相关,25-OH-D可能参与了SLE的炎症进程。

关键词: 系统性红斑狼疮, 25-羟基维生素D, 白介素-17

Abstract: Objective To assess the 25-hydroxyvitamin D (25-OH-D) and interleukin-17(IL-17) status in patients with systemic lupus erythematosus(SLE) and its clinical significance. Methods 40 SLE patients along with 20 matched controls were collected. Chemilumineseent immunoassay (CLIA) was used to detect the levers of serum 25-OH-D. The levels of serum IL-17 were evaluated using enzyme-linked immunosorbent assay (ELISA). Results Serum 25-OH-D level in SLE patients was significantly lower than in healthy controls (P<0.01). Serum 25-OH-D level in active SLE patients was significantly lower than in inactive SLE patients (P<0.01). Lever of IL-17 was significantly higher in SLE patients than in healthy controls (P<0.01). Insufficiency of 25-OH-D was related to renal disorders. Serum 25-OH-D level was negatively correlated with systemic lupus erythematosus disease activity index (SLEDAI) scores(r=-0.844, P<0.01)and serum levels of IL-17(r=-0.596, P<0.01). Conclusion Insufficiency of 25-OH-D is prevalent in SLE patients. It is associated with nephritis, disease activity and high serum levels of IL-17, thus it may play an important part in the inflammatory process in SLE.

Key words: Systemic lupus erythematosus, 25-OH-D, Interleukin-17

唐莼, 林小军, 余纳, 叶静华, 李伟念, 何志翔, 李芳菲, 蔡小燕. 系统性红斑狼疮患者血清维生素D和白介素-17水平变化及其临床意义[J]. 广州医药, 2017, 48(3): 12-16.

TANG Chun, LIN Xiaojun, YU Na, YE Jinghua, LI Weinian, HE Zhixiang, LI Fangfei, CAI Xiaoyan. Clinical significance of changes on serum levels of vitamin D and interleukin-17 in patients with systemic lupus erythematosus[J]. Guangzhou Medical Journal, 2017, 48(3): 12-16.

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系统性红斑狼疮患者血清维生素D和白介素-17水平变化及其临床意义

Clinical significance of changes on serum levels of vitamin D and interleukin-17 in patients with systemic lupus erythematosus

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