白癜风初诊患者外周血细胞因子水平与临床分型、皮损面积的相关性研究

doi:10.3969/j.issn.1000-8535.2016.03.012

广州医药 ›› 2016, Vol. 47 ›› Issue (3): 33-35.DOI: 10.3969/j.issn.1000-8535.2016.03.012

白癜风初诊患者外周血细胞因子水平与临床分型、皮损面积的相关性研究

文昌晖

贵阳中医学院第一附属医院(贵阳 520100)

收稿日期:2016-01-26 出版日期:2016-05-20 发布日期:2021-11-30

The correlation of cytokine level of peripheral blood cells, clinical classification and skin lesion in primary diagnosis patients with vitiligo

Wen Changhui

The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guiyang 520100,China

Received:2016-01-26 Online:2016-05-20 Published:2021-11-30

摘要/Abstract

摘要： 目的探讨白癜风初诊患者外周血细胞因子水平与临床分型、皮损面积的相关性。方法收集我院2009年7月—2013年7月4年间收治的初诊白癜风患者78例及健康志愿者37例,用ELISA检测外周血血清IL-6、IL-2, IFN-γ、TNF-α浓度并判断其与白癜风分型、皮损程度的相关性。结果与对照组相比,白癜风各分型组的IL-6、IL-2水平均升高,其中,散在性的升高幅度最为明显。IL-6及IL-2与皮损面积呈正相关,其相关系数分别为0.664及0.483,P值分别为0.021及0.014。结论 IL-2及IL-6在白癜风的发病过程中起重要作用,且在不同的分型中的表达存在差异,并与皮损面积呈正相关。

关键词: 白癜风, 分型, 细胞因子, 相关性

Abstract: Objective To evaluate the correlation of cytokine level of peripheral blood cells, clinical classification and skin lesion in preliminary diagnosis of vitiligo. Methods A total of 78 patients with vitiligo of preliminary diagnosis and 37 health volunteers were collected from July 2009 to July 2013. The peripheral blood were collected for ELISA measurement of IL-6, IL-2, IFN-γand TNF-α, and evaluated whether the cytokines concentration was correlated to clinical classification and skin lesion. Results Compared to control group, IL-6 and IL-2 in all of classification of vitiligo was higher, and the most increase was observed in scattered group. Both IL-6 and IL-2 showed the positive correlation with skin lesion (CI: 0.664 and 0.483, P=0.021 and 0.014). Conclusion IL-2 and IL-6 maybe play a key role in vitiligo etiology, and showed different level in different classification of vitiligo. Besides, they showed a positive correlation with skin lesion.

Key words: Vitiligo, Classfication, Cytokine, Correlation

文昌晖. 白癜风初诊患者外周血细胞因子水平与临床分型、皮损面积的相关性研究[J]. 广州医药, 2016, 47(3): 33-35.

Wen Changhui. The correlation of cytokine level of peripheral blood cells, clinical classification and skin lesion in primary diagnosis patients with vitiligo[J]. Guangzhou Medical Journal, 2016, 47(3): 33-35.

参考文献

[1] YAGHOOBI R,0MIDIAN M,BAGHERANI N. Vitiligo:a review of the published work[J]. J Dermatol,2011,38(5):419-431.
[2] 中国中西医结合学会皮肤性病专业委员会色素病学组.白癜风临床分型及疗效标准 [J]. 中华皮肤科杂志,2004,37(7):440.
[3] ARYA RK,GUPTA DK,CHAUDHARY SC. A rare case of autoimmune polyglandular syndrome type IIIc[J]. Indian J Endoerinol Metab,2012,16(3):480.
[4] 张孟丽,马鹏程.白癜风免疫学研究进展[J]. 中国美容医学,2011,20(7):1181-1183.
[5] PICHLER R, SFETSOS K, BADICS B, et al. Lymphocyte imbalance in vitiligo patients indicated by elevated CD4C/CD8C T-cell ratio[J]. Wien Med Wochenschr,2009,159:337-341.
[6] ZHOU L,LI K,SHI YL, et al. Systemic anaIyses of immunopheno-types of peripheralT ceIls in non-segmental vitiligo:implication of defective nalural killer T celIs[J]. Pigment cell Melanoma Res,2012,25(5):602-611.
[7] YU HS, CHANG KL, YU CL, et al. Alterations in IL-6, IL-8, GM-CSF, TNF-alpha, and IFN-gamma release by peripheral mononuclear cells in patients with active vitiligo[J]. Invest Dermatol,1997,108:527-529.
[8] ZAILAIE MZ. Decreased proinflammatory cytokine production by peripheral blood mononuclear cells from vitiligo patients following aspirin treatment[J]. Saudi Med,2005,26:799-805.
[9] KIRNBAUER R, CHARVAT B, SCHAUER K, et al. Modulation of intercellular adhesion molecule-1 expression on human melanocytes and melanoma cells: Evidence for a regulatory role of IL-6, IL-7, TNF-α and UVB light[J]. Invest Dermatol,1992,98:320-326.
[10] MORELLI JG, NORRIS DA. Influence of inflammatory mediators and cytokines on human melanocyte function[J]. Invest Dermatol,1993,100:191-195.
[11] YEO UC, YANG YS, PARK KB, et al. Serum concentration of the soluble interleukin-2 receptor in vitiligo patients[J]. Dermatol Sci,1999,19:182-188.
[12] GALADARI I. Serum levels of the soluble interleukin-2 receptor in vitiligo patients in UAE. Eur Ann Allergy[J]. Clin Immunol, 2005,37:109-111.

白癜风初诊患者外周血细胞因子水平与临床分型、皮损面积的相关性研究

The correlation of cytokine level of peripheral blood cells, clinical classification and skin lesion in primary diagnosis patients with vitiligo

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