广州医药 ›› 2015, Vol. 46 ›› Issue (5): 9-10.DOI: 10.3969/j.issn.1000-8535.2015.05.003

• 论著 • 上一篇    下一篇

12例原发性肺淋巴上皮瘤样癌的临床病理分析

王康玮1, 魏树全2, 陈少红2, 刘国荣2, 唐昭亮1, 史文利1, 杜洪2   

  1. 1 广州市南沙中心医院 (广州 511457)
    2 广州市第一人民医院 (广州 510180)
  • 收稿日期:2015-03-23 发布日期:2021-11-30

Clinicopathologic analysis of 12 cases with primary lymphoepithelioma-like carcinoma of the lung

Wang Kangwei, Wei Shuquan, Chen Shaohong, Liu Guorong, Tang Zhaoliang, Shi Wenli, et al   

  1. Guangzhou Nansha Central Hospital, Guangzhou 511457, China;
    Guangzhou First People's Hospital, Guangzhou 510180, China
  • Received:2015-03-23 Published:2021-11-30

摘要: 目的 分析总结12例原发性肺淋巴上皮瘤样癌(LELC)的临床病理特点。方法 回顾性分析12例肺LELC患者的临床病理资料。结果 12例肺LELC患者的组织学标本中,肿瘤细胞均明显表达HCK,原位杂交EBER阳性率为91.7%。全组中位生存期61.3个月,2年和5年生存率分别为84.6%和57.7%。结论 原发性肺LELC临床罕见,发病可能与EB病毒感染有关,经及时治疗有较好的预后。

关键词: 肺淋巴上皮瘤样癌, 肺癌, 临床病理特征, 回顾性分析

Abstract: Objective To investigate the pathological and clinical significance of 12 cases with primary Lymphoepithelioma-like carcinoma of the lung (LELC). Methods Retrospectively detectded and analyzed the clincalpathological feature of 12 cases of LELC of the lung. Results Histological study showed that tumor cells were significantly expressed HCK by immunohistochemistry staining and showed out 91.7% positive rate of EBER by situ hybridization. In this series, the median survival time was 61.3 months. The overall 2 and 5 year survival rates of the 12 cases were 84.6% and 57.7%. Conclusion Pulmonary LELC is very rare. It may be associated with Epstein-Barr virus infection, and has a batter prognosis after therapy.

Key words: Lung cancer, Lymphoepithelioma-like carcinoma, Pathology, Retrospective analysis