6161个自然周期供精人工授精临床妊娠分析

doi:10.3969/j.issn.1000-8535.2015.04.012

广州医药 ›› 2015, Vol. 46 ›› Issue (4): 37-40.DOI: 10.3969/j.issn.1000-8535.2015.04.012

6161个自然周期供精人工授精临床妊娠分析

刘宇¹, 杨桂萍², 宋革¹, 陈瑞玲¹, 钟小英¹, 郑炜炜¹, 李秋华¹, 曾丽萍¹, 陆艳华¹

1 广东省计划生育专科医院 (广州 510060)
2 中山大学附属第一医院 (广州 510080)

收稿日期:2015-05-19 发布日期:2021-11-30
通讯作者: 刘宇,E-mail:2402730282@qq.com
基金资助:
广东省人口计生委科技项目(A2014194)

Analysis of the parameters affecting pregnancy outcome of 6161 cases of artificial insemination by donor

Liu Yu, Yang Guiping, Song Ge, Chen Ruiling, et al

Guangdong Family Planning Institute,Reproductive Department Guangzhou,Guangzhou 510060,China;
The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China

Received:2015-05-19 Published:2021-11-30

摘要/Abstract

摘要： 目的探讨影响自然周期供精人工授精妊娠的因素。方法回顾性分析2007年4月—2013年4月期间在广东省计划生育专科医院行自然周期供精人工授精的6161个周期,其中妊娠组1454周期,对照组4707个周期。采用单因素分析及多因素Logistic回归分析女方年龄、不孕年限、子宫内膜厚度、类型及冻融复苏后前向运动精子总数与AID妊娠结局的关系。结果年龄越大,不孕年限越长,妊娠率越低(P＜0.001); A型子宫内膜妊娠率25.94%较AB型的23.87%及B型的21.54%都高(P=0.001);妊娠组冻融复苏后前向运动精子总数均值(28.95±6.86)×10⁶较对照组的(28.26±6.98)×10⁶高(P=0.001);年龄(OR=1.614,P＜0.001)、不孕年限(OR=1.194,P=0.012)、子宫内膜分型(OR=1.258,P=0.001)影响妊娠率。结论女方年龄、不孕年限、子宫内膜形态及冻融复苏后前向运动精子总数是影响自然周期供精人工授精妊娠的因素。

关键词: 供精人工授精, 自然周期, 临床妊娠, Logistic回归分析

Abstract: Objective To explore the parameters affecting the pregnancy rate from 6161 natural cycles of artificial insemination by donor(AID). Methods Consecutive cases of 6161 natural cycles of AID from April,2009 to April 2013 in Guangdong provincial family planning special hospital were analyzed retrospectively.1454 pregnant cycles were defined as observation group and the other 4707 non pregnant cycles were classified as control group.Related factors in effect of pregnancy rate of AID were analyzed by logistic regression analysis. Results The rate of pregnancy decreased with the increase of women ages and the infertility duration(P＜0.001).And the pregnancy rate of ICI among the women with type A endometrium was the highest among the three types of endometrium(25.94%vs23.87%vs21.54%,P=0.001).The sum of the forward moving sperm after freezing and thawing recovery of observation group is higher than control group(28.95±6.86)×10⁶vs (28.26±6.98)×10⁶.The value of OR of age,infertility duration and types of endometrium were 1.614,1.194 and 1.258,respectively. Conclusion Age of women,infertility duration,types of endometrium as well as the sum of the forward moving sperm after freezing and thawing recovery played an important role in pregnancy rate of natural cycles of AID.

Key words: Artificial insemination by donor, Outcome of pregnancy, Natural cycles, Logistic regression analysis

刘宇, 杨桂萍, 宋革, 陈瑞玲, 钟小英, 郑炜炜, 李秋华, 曾丽萍, 陆艳华. 6161个自然周期供精人工授精临床妊娠分析[J]. 广州医药, 2015, 46(4): 37-40.

Liu Yu, Yang Guiping, Song Ge, Chen Ruiling, et al. Analysis of the parameters affecting pregnancy outcome of 6161 cases of artificial insemination by donor[J]. Guangzhou Medical Journal, 2015, 46(4): 37-40.

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6161个自然周期供精人工授精临床妊娠分析

Analysis of the parameters affecting pregnancy outcome of 6161 cases of artificial insemination by donor

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