低浓度布比卡因联合全身麻醉对腹腔镜下直肠癌根治术患者体征及苏醒质量的影响

doi:10.3969/j.issn.1000-8535.2024.03.013

广州医药 ›› 2024, Vol. 55 ›› Issue (3): 295-299.DOI: 10.3969/j.issn.1000-8535.2024.03.013

低浓度布比卡因联合全身麻醉对腹腔镜下直肠癌根治术患者体征及苏醒质量的影响

宋水涛¹, 周辉¹, 丁国埕¹, 李阳²

1 信阳一五四医院麻醉科（河南信阳 464000）;
2 信阳一五四医院普外科（河南信阳 464000)

收稿日期:2023-03-27 出版日期:2024-03-20 发布日期:2024-04-12
基金资助:
河南省医学科技攻关项目（LHGJ2021004421）

Clinical study on the effect of low concentration bupivacaine combined with general anesthesia on the physical signs and recovery quality of patients undergoing laparoscopic radical resection of rectal cancer

SONG Shuitao¹, ZHOU Hui¹, DING Guocheng¹, LI Yang²

1 Department of Anesthesiology,Xinyang 154th Hospital,Xinyang 464000,China;
2 Department of General Surgery,Xinyang 154th Hospital,Xinyang 464000,China

Received:2023-03-27 Online:2024-03-20 Published:2024-04-12

摘要/Abstract

摘要： 目的观察低浓度布比卡因联合全身麻醉在腹腔镜下直肠癌根治术中的应用及对患者体征及苏醒质量的影响。方法选择2020年1月—2021年6月在信阳一五四医院实施腹腔镜镜下直肠癌根治术治疗的126例直肠癌患者为研究对象,通过抽签法对患者进行分组,将其中63例列为全麻组,术中单纯实施全身麻醉,其余63例列为联合组,术中采用低浓度布比卡因联合全身麻醉,比较两组患者体征变化情况,苏醒质量,麻醉相关不良反应,并开展为期1.5年的随访,评估两组患者远期生存质量。结果联合组术中、术后的心率、平均动脉压均低于全麻组（P<0.05）;术后,联合组的Steward麻醉苏醒评分略低于全麻组、麻醉恢复室停留时间略高于全麻组（P>0.05）;但联合组的视觉模拟疼痛评分、镇静评分均低于全麻组（P<0.05）;联合组的麻醉相关不良反应发生率略高于全麻组（P>0.05）;随访期间,联合组的肠癌患者生存质量测定量表各维度评分均高于全麻组（P<0.05）。结论低浓度布比卡因联合全身麻醉的麻醉效果更加平稳、安全性高。

关键词: 腹腔镜下直肠癌根治术, 低浓度布比卡因, 全身麻醉, 麻醉效果

Abstract: Objective To observe the application of low concentration bupivacaine combined with general anesthesia in laparoscopic radical resection of rectal cancer and its effect on the physical signs and recovery quality of patients. Methods In this study,126 rectal cancer patients who underwent laparoscopic radical resection of rectal cancer in Xinyang 154th Hospital from January 2020 to June 2021 were selected as the research subjects．The patients were divided into groups by drawing lots．Among them,63 patients were included in general anesthesia group,and the rest 63 patients were included in combined group．Low-concentration bupivacaine combined with general anesthesia was used in combined group during the operation．The changes of physical signs and the quality of recovery were compared between the two groups．Anesthesia related adverse events,and the long-term quality of life of the two groups of patients was evaluated through one-year and a half follow-up. Results The heart rate and mean arterial pressure during and after surgery in the combined group were lower than those in the general anesthesia group（P<0.05）．After surgery,the Steward anesthesia recovery score of the combined group was slightly lower than that of the general anesthesia group,and the PACU stay time was slightly higher than that of the general anesthesia group（P>0.05）．However,the VAS score and Richmond Agitation-Se dation Scale score of the combined group were lower than those of the general anesthesia group（P<0.05）．The incidence of anesthesia related adverse reactions in the combination group was slightly higher than that in the general anesthesia group（P>0.05）．During the follow-up period,the FACT-C scores of all dimensions in the combination group were higher than those in the general anesthesia group（P<0.05）. Conclusions The anesthesia effect of low concentration bupivacaine combined with general anesthesia is significant and safe．

Key words: laparoscopic radical resection of rectal cancer, low-concentration bupivacaine, general anesthesia, anesthetic effect

宋水涛, 周辉, 丁国埕, 李阳. 低浓度布比卡因联合全身麻醉对腹腔镜下直肠癌根治术患者体征及苏醒质量的影响[J]. 广州医药, 2024, 55(3): 295-299.

SONG Shuitao, ZHOU Hui, DING Guocheng, LI Yang. Clinical study on the effect of low concentration bupivacaine combined with general anesthesia on the physical signs and recovery quality of patients undergoing laparoscopic radical resection of rectal cancer[J]. Guangzhou Medical Journal, 2024, 55(3): 295-299.

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低浓度布比卡因联合全身麻醉对腹腔镜下直肠癌根治术患者体征及苏醒质量的影响

Clinical study on the effect of low concentration bupivacaine combined with general anesthesia on the physical signs and recovery quality of patients undergoing laparoscopic radical resection of rectal cancer

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