来曲唑和氯米芬治疗极严重少精子症的疗效分析

doi:10.3969/j.issn.1000-8535.2022.05.022

广州医药 ›› 2022, Vol. 53 ›› Issue (5): 105-108.DOI: 10.3969/j.issn.1000-8535.2022.05.022

来曲唑和氯米芬治疗极严重少精子症的疗效分析

甄国志, 林冰, 麦福劲, 叶宇, 曹健欣, 梁宇玲

广东医科大学顺德妇女儿童医院生殖医学中心(顺德 528300)

收稿日期:2022-01-21 出版日期:2022-09-20 发布日期:2022-10-11

Efficacy of letrozole and clomiphene in the treatment of extremely severe oligospermia

ZHEN Guozhi, LIN Bing, MAI Fujing, YE Yu, CAO Jianxin, LIANG Yuling

Department of Reproductive Medicine, Shunde Women's and Children's Hospital, Guangdong Medical University,Shunde 528300,China

Received:2022-01-21 Online:2022-09-20 Published:2022-10-11

摘要/Abstract

摘要： 目的比较来曲唑和氯米芬治疗极严重少精子症的治疗效果。方法选取2020—2021年在本生殖中心门诊50例极严重少精子症病例,分为2组,A组(来曲唑,研究组n=26)、B组(氯米芬,对照组n=24)。结果来曲唑和氯米芬治疗后1月、3月,A组精子浓度明显提高,优于B组[(4.5±3.1) vs (2.0±1.3);(8.3±3.5) vs (2.0±1.8),P<0.05]。通过卵胞浆内单精子注射/体外受精胚胎移植治疗,A组妊娠16例(61.5%),B组妊娠11例(45%)。2组治疗后的血清卵泡刺激素、黄体生成素、睾酮升高[(5.9±3.8) vs (20.3±2.6);(3.6±2.8) vs (9.5±5.7);(13.6±10.5) vs (25.3±10.8),P<0.05],A组雌二醇水平降低[(36.8±20.6) vs (7.6±2.5),P<0.05]。结论来曲唑治疗极严重少精子症有较理想的临床治疗效果,明显优于氯米芬。

关键词: 来曲唑, 氯米芬, 极严重少精子症

Abstract: Objective To explore and compare the therapeutic effects of letrozole and clomiphene in the treatment of extremely severe oligospermia. Methods A tatal of 50 cases of extremely severe oligosperospermia in the reproductive center from 2020 to 2021 were selected and divided into two groups, group A (letrozole, study group n=26) and B (clomiphene, control group n=24). Results After letrizole and clomiphene treated for 1 and 3 months, sperm concentration in group A was significantly better than group B[(4.5±3.1) vs (2.0±1.3);(8.3±3.5) vs (2.0±1.8),P<0.05]. With ICSI/IVF, 16 cases (61.5%) succeed in encyesis in group A, 11 cases (45%) in group B. Serum follicle stimulating hormone, luteinizing hormone and testosterone levels were significantly increased after treatment [(5.9±3.8) vs (20.3±2.6), (3.6±2.8) vs (9.5±5.7), (13.6±10.5) vs (25.3±10.8), P<0.05]. The level of estradiol in group A decreased [(36.8±20.6) vs (7.6±2.5), P<0.05]. Conclusions Letrozole has ideal clinical treatment effect, which is obviously superior to clommiphene.

Key words: letrozole, clomeiphene, extremely oligospermia

甄国志, 林冰, 麦福劲, 叶宇, 曹健欣, 梁宇玲. 来曲唑和氯米芬治疗极严重少精子症的疗效分析[J]. 广州医药, 2022, 53(5): 105-108.

ZHEN Guozhi, LIN Bing, MAI Fujing, YE Yu, CAO Jianxin, LIANG Yuling. Efficacy of letrozole and clomiphene in the treatment of extremely severe oligospermia[J]. Guangzhou Medical Journal, 2022, 53(5): 105-108.

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来曲唑和氯米芬治疗极严重少精子症的疗效分析

Efficacy of letrozole and clomiphene in the treatment of extremely severe oligospermia

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