炎症性肠病活动程度与血脂水平的相关性分析

doi:10.3969/j.issn.1000-8535.2019.02.006

广州医药 ›› 2019, Vol. 50 ›› Issue (2): 24-27.DOI: 10.3969/j.issn.1000-8535.2019.02.006

炎症性肠病活动程度与血脂水平的相关性分析

谌黄威¹, 刘浏¹, 熊婷², 罗夏朋¹, 黄鹤¹, 贾柳萍¹

1 南方医科大学附属南海医院消化内科 (佛山 528200)
2 南方医科大学附属南海医院心胸耳鼻喉科(佛山 528200)

收稿日期:2018-12-04 出版日期:2019-03-20 发布日期:2021-12-17
通讯作者: 谌黄威,E-mail: chw1364@163.com
基金资助:
广东省佛山市医学类科技攻关项目(2015AB000012)

Clinical analysis of the correlations between disease activity of inflammatory bowel disease and lipid profiles

CHEN Huangwei¹, LIU Liu¹, XIONG Ting², LUO Xiapeng¹, HUANG He¹, JIA Liuping¹

1 Department of Gastroenterology,Nanhai Hospital of Southern Medical University,Foshan 528200,China
2 Department of Cardiothoracic and E.N.T,Nanhai Hospital of Southern Medical University,Foshan 528200, China.

Received:2018-12-04 Online:2019-03-20 Published:2021-12-17

摘要/Abstract

摘要： 目的通过比较炎症性肠病(IBD)患者的血脂水平,探讨炎症性肠病疾病活动程度与血脂的相关性。方法收集2013年1月—2018年5月在南方医科大学附属南海医院住院的159例IBD患者和159例健康对照为研究对象,检测分析两组的血浆TG、TC、LDL-C、HDL-C、脂蛋白a、白蛋白和超敏C反应蛋白(hCRP)水平差异,分析IBD患者疾病活动程度与血脂异常的关系。结果与对照组比较,IBD患者的TG、TC、LDL-C、HDL-C和白蛋白均下降,但脂蛋白a升高(P＜0.05),且CD组的TC、LDL-C、HDL-C、白蛋白均较UC组更低(P＜0.05)。TC、LDL-C、HDL-C等胆固醇水平随IBD疾病活动程度加重而逐渐下降,且与hCPR呈负相关,脂蛋白a与hCRP呈正相关性,但未见TG水平与疾病活动相关。结论 IBD患者的胆固醇水平下降,脂蛋白a升高,CD患者更明显,胆固醇水平随IBD病情加重逐渐下降,且与hCRP呈负相关。

关键词: 炎症性肠病, 疾病活动程度, 血脂

Abstract: Objective To explore the correlations between disease activity of inflammatory bowel disease(IBD) and lipid profiles levels by compare the levels of plasma lipids in patients with IBD. Methods A total of 159 IBD patients admitted to Nanhai Hospital of Southern Medical University from January 2013 to May 2018 were included in the study and the clinical data were collected. There were 159 healthy people recruited in the control group. The differences of plasma levels of triglycerides(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), lipoprotein(a), albumin and high-sensitivity C-reactive protein(hCRP) between these two groups were analyzed respectively. The relationships between lipids levels and the severity of IBD were analyzed. Results Plasma levels of TG,TC,LDL-C,HDL-C and albumin were lower in IBD group than those in control group,but lipoprotein(a) was higher than control group(P＜0.05). The levels of TC,LDL-C,HDL-C and albumin were lower in CD patients compared to those of UC(P＜0.05). Plasma levels of TC,LDL-C,HDL-C gradually decreased with the severity of IBD. TC,LDL-C,HDL-C values were negatively correlated with hCRP levels in IBD patients. And lipoprotein(a) values was positively correlated with hCRP levels in IBD patient. However, there was no association between TG levels and the severity of IBD. Conclusion TG、TC、LDL-C、HDL-C levels are decreased and lipoprotein(a) is increased in IBD patients, especially CD patients, compared with healthy controls. Moreover, the cholesterol levels are negatively associated with more severe disease activity.

Key words: Inflammatory bowel disease, Disease activity, Lipid profiles

谌黄威, 刘浏, 熊婷, 罗夏朋, 黄鹤, 贾柳萍. 炎症性肠病活动程度与血脂水平的相关性分析[J]. 广州医药, 2019, 50(2): 24-27.

CHEN Huangwei, LIU Liu, XIONG Ting, LUO Xiapeng, HUANG He, JIA Liuping. Clinical analysis of the correlations between disease activity of inflammatory bowel disease and lipid profiles[J]. Guangzhou Medical Journal, 2019, 50(2): 24-27.

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炎症性肠病活动程度与血脂水平的相关性分析

Clinical analysis of the correlations between disease activity of inflammatory bowel disease and lipid profiles

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