加减香砂六君子汤联合三联疗法治疗慢性萎缩性胃炎临床观察

doi:10.3969/j.issn.1000-8535.2019.01.007

广州医药 ›› 2019, Vol. 50 ›› Issue (1): 28-32.DOI: 10.3969/j.issn.1000-8535.2019.01.007

加减香砂六君子汤联合三联疗法治疗慢性萎缩性胃炎临床观察

罗曼虹

广州市越秀区中医医院（广州 510030)

收稿日期:2018-07-25 出版日期:2019-01-20 发布日期:2021-12-21

Clinical observation of Jiajianxiashaliujunzi decoction combined with triple therapy for chronic atrophic gastritis

LUO Manhong

Guangzhou Yuexiu District Chinese Medicine Hospital,Guangzhou 510030,China

Received:2018-07-25 Online:2019-01-20 Published:2021-12-21

摘要/Abstract

摘要： 目的研究加减香砂六君子汤联合三联疗法治疗慢性萎缩性胃炎的临床疗效。方法将100例慢性萎缩性胃炎患者随机分为对照组和观察组各50例,对照组患者给予三联疗法而观察组在对照组基础上辨证使用加减香砂六君子汤加减进行治疗。对临床疗效进行评估,观察两组患者临床症状并测定血清中超氧化物歧化酶（SOD）、丙二醛（MDA）水平的变化,统计两组的幽门螺杆菌（Hp）转阴率及复发率、根除率。结果治疗以后统计有效率,观察组为92%,而对照组仅有76%,胃胀、胃痛、痞满、反酸、饮食减少等症状均缓解,各症状的积分治疗后均降低,两组相比其差异有统计学意义,观察组的Hp转阴率为92.0%,对照组Hp转阴率为68.0% ,两组Hp转阴率比较,差异有统计学意义。两组SOD水平均较治疗前上升,MDA水平均较治疗前下降,SOD水平高于对照组,MDA水平低于对照组,差异均有统计学意义（P<0.05）。结论加减香砂六君子汤联合三联疗法治疗慢性萎缩性胃炎可显著改善患者的临床症状,有良好的应用前景。

关键词: 慢性萎缩性胃炎, 加减香砂六君子汤, 三联疗法

Abstract: Objective To observe the clinical effect of Jiajianxiangshaliujunzi decoction combined with triple therapy for chronic atrophic gastritis. Methods We selected 100 cases of patients with chronic atrophic gastritis of intertwined,and divided them into the control group and the observation group randomly with 50 cases in each group. The control group was given triple therapy for treatment,while the observation group was additionally given Jiajianxiangshaliujunzi decoction based on the syndrome differentiation for treatment. We observed the changes of clinical symptoms and levels of superoxide dismutase（SOD） and malondialdehyde（MDA） in serum of both groups. The negative conversion rate,recurrence rate and eradication rate of Helicobacter pylori （Hp） in 2 groups were statistically analyzed,in both groups and the clinical effect. Results After treatment,the total effective rates were counted: the observation group was 92%,and the control group was only 76%. The symptoms such as stomach distention,stomachache,distention and fullness,acid reflux,and diet reduction were reduced after the treatment. The difference between the two groups had statistical significance. In the two groups of stomachache,fullness and boredom,low appetite and acid regurgitation scores were all lower than those before treatment,and the differences were statistically significant. The negative rate of Hp in the observation group was 92%,while the negative rate of Hp in the control group was 68%. There was difference between the two groups in the negative rate of Hp. The levels of SOD in both groups were higher than those before treatment,and the levels of MDA were lower than those before treatment,differences being significant（P< 0.05）;the level of SOD in the observation group was higher than that in the control group,and the level of MDA was lower than that in the control group. Difference was statistically significant. （P< 0.05）. Conclusion Jiajianxiangshaliujunzi decoction combined with triple therapy for chronic atrophic gastritis may improve clinical symptoms of patients,and promote the negative rate of Hp as well as the clinical effect.

Key words: Chronic atrophic gastritis, Jiajianxiangshaliujunzi decoction, Triple therapy

罗曼虹. 加减香砂六君子汤联合三联疗法治疗慢性萎缩性胃炎临床观察[J]. 广州医药, 2019, 50(1): 28-32.

LUO Manhong. Clinical observation of Jiajianxiashaliujunzi decoction combined with triple therapy for chronic atrophic gastritis[J]. Guangzhou Medical Journal, 2019, 50(1): 28-32.

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加减香砂六君子汤联合三联疗法治疗慢性萎缩性胃炎临床观察

Clinical observation of Jiajianxiashaliujunzi decoction combined with triple therapy for chronic atrophic gastritis

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[1]	伦伟健, 梁晓燕, 黄鹤. 胃蛋白酶原、胃泌素17和HP感染与慢性萎缩性胃炎和肠上皮化生的相关性[J]. 广州医药, 2018, 49(3): 26-28.
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