碱性磷酸酶对透析患者血管钙化和骨质疏松评估价值

doi:10.3969/j.issn.1000-8535.2018.03.003

广州医药 ›› 2018, Vol. 49 ›› Issue (3): 10-14.DOI: 10.3969/j.issn.1000-8535.2018.03.003

碱性磷酸酶对透析患者血管钙化和骨质疏松评估价值

潘健怡, 胡海棠, 张炜, 陈进忠, 窦献蕊

南方医科大学顺德医院(佛山市顺德区第一人民医院)(顺德 528300)

收稿日期:2018-01-16 出版日期:2018-05-20 发布日期:2021-12-01
通讯作者: 窦献蕊,E-mail:betty9911@163.com
基金资助:
佛山市科技局立项(2015AB002093)

The evaluation value of alkaline phosphatase in vascular calcification and osteoporosis in dialysis patients

PAN Jianyi, HU Haitang, ZHANG Wei, CHEN Jinzhong, DOU Xianrui

Shunde Hospital of Southern Medical University(The First Peopl's Hospital of Shunde), Shunde 528300, China

Received:2018-01-16 Online:2018-05-20 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨血碱性磷酸酶水平对维持性透析患者血管钙化与骨质疏松的评估价值。方法纳入我院186例维持性透析患者,记录相关临床资料并完善实验室检查,以X线片评价血管钙化情况,双能X线吸收法检查骨密度。对上述资料进行双变量相关分析、ROC曲线分析等统计学处理。结果血碱性磷酸酶水平与股骨颈骨密度负相关,与腹主动脉钙化评分正相关。腹主动脉钙化评分与骨密度负相关。ALP对骨质疏松及严重腹主动脉钙化诊断的ROC曲线下面积分别为0.777及0.701。结论碱性磷酸酶是评估透析患者血管钙化骨质疏松的良好指标。

关键词: 维持性透析, 碱性磷酸酶, 血管钙化, 骨密度

Abstract: Objective To explore evaluation value of alkaline phosphatase in vascular calcification and osteoporosis in maintenance dialysis patients. Methods 186 patients in maintenance dialysis were enrolled in this study. The related clinical data was recorded. The examination of X-ray (lateral abdomens) was done to estimate vascular calcification in patients. Bone mineral density was measured by dual energy X-ray absorptiometry. The results above were analyzed by bivariate correlation analysis and receiver operator characteristic curve. Results By bivariate correlation analysis,serum alkaline phosphatase level was negatively associated with femoral neck bone mineral density, and was positively associated with abdominal aortas calcification scores. Abdominal aortas calcification scores were negatively associated with femoral neck bone mineral density. ROC curve revealed AUCs were respectively 0.777 and 0.701 for serum alkaline phosphatase level in diagnosis of osteoporosis and severe abdominal aortas calcification. Conclusion Alkaline phosphatase may be a good index to evaluate calcification and osteoporosis in maintenance dialysis patients.

Key words: Maintenance dialysis, Alkaline phosphate, Vascular calcification, Bone mineral density

潘健怡, 胡海棠, 张炜, 陈进忠, 窦献蕊. 碱性磷酸酶对透析患者血管钙化和骨质疏松评估价值[J]. 广州医药, 2018, 49(3): 10-14.

PAN Jianyi, HU Haitang, ZHANG Wei, CHEN Jinzhong, DOU Xianrui. The evaluation value of alkaline phosphatase in vascular calcification and osteoporosis in dialysis patients[J]. Guangzhou Medical Journal, 2018, 49(3): 10-14.

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碱性磷酸酶对透析患者血管钙化和骨质疏松评估价值

The evaluation value of alkaline phosphatase in vascular calcification and osteoporosis in dialysis patients

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