木棉花水提取物抗炎镇痛作用的实验研究

doi:10.3969/j.issn.1000-8535.2018.01.002

广州医药 ›› 2018, Vol. 49 ›› Issue (1): 5-8.DOI: 10.3969/j.issn.1000-8535.2018.01.002

木棉花水提取物抗炎镇痛作用的实验研究

刘金泳¹, 邱素君¹, 陈芳超¹, 吴彬¹, 王红珊¹, 孔智毅¹, 臧林泉²

1 广州市第一人民医院南沙医院药学科(广州 511458);
2 广东药科大学药学院药理系(广州 510006)

收稿日期:2017-09-28 出版日期:2018-01-20 发布日期:2021-12-01

Experimental study on the anti-inflammatory and analgesic effects of the water extract of Bombax Malabaricum DC. Flower

LIU Jinyong¹, QIU Sujun¹, CHEN Fangchao¹, WU Bin¹, WANG Hongshan¹, Kong Zhiyi¹, ZANG Linquan²

1 Department Of Pharmacy,Nansha Hospital of Guangzhou First People's Hospital, Guangzhou 511458,China
2 Pharmacology,College of Pharmacy, Guangdong Pharmaceutical University,Guangzhou 510006,China

Received:2017-09-28 Online:2018-01-20 Published:2021-12-01

摘要/Abstract

摘要： 目的初步研究木棉花水提取物抗炎镇痛作用。方法采用二甲苯和醋酸作为致炎和致痛因子,通过小鼠耳廓肿胀实验、腹腔毛细血管通透性实验与扭体实验,考察灌胃高、中、低剂量的木棉花水提取物的抗炎、镇痛作用。结果小鼠对于木棉花水提取物的最大耐受量为300 g/kg;木棉花水提取物高剂量(150 g/kg)和中剂量(100 g/kg)均能抑制小鼠耳廓肿胀,降低小鼠腹腔血管通透性;木棉花水提取液各剂量组均能有效地减少小鼠的扭体次数,且作用随剂量增加而增强。结论木棉花水提取物具有抗炎镇痛作用。

关键词: 木棉花, 抗炎, 镇痛

Abstract: Objective To study the anti-inflammatory and analgesic effect of water extract of Bombax malabaricum DC. Flower. Methods The xylene and acetic acid were used as inflammation and pain factors. The auricle swelling test,intraperitoneal capillary permeability test and writhing experiment were performed to study the anti-inflammatory and analgesic effect with high,medium and low dose of water extract of Bombax malabaricum DC. Flower. Results The maximum tolerated dose of mice for Bombax malabaricum DC. Flower was 300 g/kg. High dose (150 g/kg) and medium dose (100 g/kg) of water extract of Bombax malabaricum DC. Flower could both inhibit mouse auricle swelling and reduce mouse peritoneal vascular permeability. All dosages of the water extract of Bombax malabaricum DC. Flower were effective in reducing the number of writhing in mice,and the effect is strengthened with the increase of dosage. Conclusion Water extract of Bombax malabaricum DC. Flower has anti-inflammatory and analgesic effects.

Key words: Bombax malabaricum DC. Flower, Anti-inflammatory, Analgesic

刘金泳, 邱素君, 陈芳超, 吴彬, 王红珊, 孔智毅, 臧林泉. 木棉花水提取物抗炎镇痛作用的实验研究[J]. 广州医药, 2018, 49(1): 5-8.

LIU Jinyong, QIU Sujun, CHEN Fangchao, WU Bin, WANG Hongshan, Kong Zhiyi, ZANG Linquan. Experimental study on the anti-inflammatory and analgesic effects of the water extract of Bombax Malabaricum DC. Flower[J]. Guangzhou Medical Journal, 2018, 49(1): 5-8.

[1]	贾梦岩, 肖军. 镇痛活络酊和外用非甾体抗炎药治疗肱骨外上髁炎的短期疗效对比研究[J]. 广州医药, 2020, 51(5): 123-129.
[2]	沈峰, 王博文. 水解乳清蛋白对炎症性肠病大鼠的抗炎作用及机制研究[J]. 广州医药, 2015, 46(6): 18-19.

木棉花水提取物抗炎镇痛作用的实验研究

Experimental study on the anti-inflammatory and analgesic effects of the water extract of Bombax Malabaricum DC. Flower

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