急性心衰患者NTpro-BNP,cTnI,hs-CRP的变化及其临床意义

doi:10.3969/j.issn.1000-8535.2017.02.013

广州医药 ›› 2017, Vol. 48 ›› Issue (2): 46-50.DOI: 10.3969/j.issn.1000-8535.2017.02.013

急性心衰患者NTpro-BNP,cTnI,hs-CRP的变化及其临床意义

汤勇才, 廖军, 黄小媛, 李焕庭

广州市第一人民医院检验科(广州 510180)

收稿日期:2016-12-13 发布日期:2021-12-01

NTpro-BNP, CTnI and Hs-CRP changes of patients with acute heart failure and its clinical significance

TANG Yongcai, LIAO Jun, HUANG Xiaohuan, LI Huangting

Department of Clinical Laboratory, Guangzhou First People's Hospital,Guangzhou 510180,China

Received:2016-12-13 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨急性心衰(AHF)患者NTpro-BNP,cTnI,hs-CRP的变化及其临床意义。方法分别选取342例AHF患者和30例同期健康查体者作为观察组和对照组。统计2组NTpro-BNP,cTnI,hs-CRP及LVEF水平及随访期间死亡率。分析患者NTpro-BNP,cTnI,hs-CRP与其LVEF的关系及其联合预测患者死亡率的价值。结果观察组NTpro-BNP,cTnI,hs-CRP均较对照组升高,LVEF则较对照组降低;与T₀比较,患者T₂、T₃、T₄的NTpro-BNP,cTnI,hs-CRP均降低,LVEF则升高;心衰较严重患者其NTpro-BNP,cTnI,hs-CRP较高,LVEF则较低(P<0.05)。观察组存活患者NTpro-BNP,cTnI,hs-CRP较低,LVEF则较高(P<0.05)。AHF患者NTpro-BNP,cTnI,hs-CRP与其LVEF均呈负相关且预测预后的价值良好。结论 AHF患者NTpro-BNP,cTnI,hs-CRP与其心功能相关且其联合预测预后的价值较高,可能作为AHF患者心功能及患者预后评估的参考指标。

关键词: 急性心衰, 左西孟旦, NTpro-BNP, cTnI, hs-CRP

Abstract: Objective To study the NTpro-BNP, cTnI and hs-CRP changes of patients with acute heart failure(AHF)and its clinical significance. Methods 342 patients with AHF and 30 healthy persons were selected as observation group and control group. NTpro-BNP, cTnI, hs-CRP and LVEF level of two groups and mortality during the follow-up period were analyzed. Relationship between NTpro-BNP, cTnI, hs-CRP and LVEF, and value of them unitedly predicting mortality of patients were analyzed. Results NTpro-BNP, cTnI, hs-CRP of observation group were higher than that of the control group while LVEF was lower than that of the control group; Compared with T₀, NTpro-BNP, cTnI, hs-CRP of observation group in T₂, T₃, T₄ were reduced while LVEF increased; Patients with more serious heart failure had higher NTpro-BNP, cTnI, hs-CRP and lower LVEF (P<0.05). NTpro-BNP, cTnI, hs- CRP of survived patients in observation group were lower while LVEF was higher(P<0.05). NTpro-BNP,cTnI and hs-CRP of AHF patients were negative correlated with LVEF and value of them predicting good prognosis. Conclusion NTpro-BNP, cTnI, hs-CRP of AHF patients are related to its heart function and the value of them unitedly predicting prognosis is good, thus they may used cardiac function and prognosis evaluation reference index of AHF patient.

Key words: Acute heart failure, Levosimendan, NTpro-BNP, CTnI, Hs-CRP

汤勇才, 廖军, 黄小媛, 李焕庭. 急性心衰患者NTpro-BNP,cTnI,hs-CRP的变化及其临床意义[J]. 广州医药, 2017, 48(2): 46-50.

TANG Yongcai, LIAO Jun, HUANG Xiaohuan, LI Huangting. NTpro-BNP, CTnI and Hs-CRP changes of patients with acute heart failure and its clinical significance[J]. Guangzhou Medical Journal, 2017, 48(2): 46-50.

参考文献

[1] 任古松,张春霞.左西孟旦治疗老年重度心力衰竭的疗效及安全性分析[J]. 天津医药,2012,40(11):1169-1170.
[2] 张娟.中性粒细胞明胶酶相关载脂蛋白在急性心力衰竭预后评估的价值[J]. 现代预防医学,2013,40(9):1783-1784;1788.
[3] 陈新,王智昊,王丽.重组人脑利钠肽的临床应用研究进展[J]. 中国老年学杂志,2013,33(12):2982-2984.
[4] HUYNH K, van TASSELL B, CHOW S L. Predicting therapeutic response in patients with heart failure: the story of C-reactive protein[J]. Expert Rev Cardiovasc Ther,2015,13(2):153-161.
[5] 余昌平.医院获得性肺炎伴心力衰竭老年患者的心功能评价指标研究[J]. 中国全科医学,2012,15(25):2889-2891.
[6] ZEMAN K, Pohludková L, SPINAR J, et al. Short-term prognosis and treatment of patients hospitalized for acute heart failure in a regional hospital without a cardiocentre[J]. Vnitr Lek,2012,58(4):273-279.
[7] de MELLO B H,OLIVEIRA G B,RAMOS RF,et al.Validation of the Killip-Kimball classification and late mortality after acute myocardial infarction[J]. Arq Bras Cardiol,2014,103(2):107-117.
[8] 杜昌.维生素D水平低下与急性心衰的相关性研究进展[J]. 现代预防医学,2012,39(15):3809-3810;3813.
[9] 田惠君.太极拳对心源性心脏手术后预防急性心衰的辅助治疗[J]. 科技通报,2014(10):19-21.
[10] SRINIVAS P, MANJUNATH C N, BANU S, et al. Prognostic significance of a multimarker strategy of biomarkers in acute heart failure[J]. J Clin Diagn Res,2014,8(9):MC01-6.
[11] 邓明红,林春旺,江少虎,等.氨基末端B型利钠肽前体和改良Ross标准对急性心力衰竭诊断界值的探讨[J]. 广东医学,2013,34(11):1698-1700.
[12] 汪红平,任颖,邵琦.甲状腺激素替代治疗在心力衰竭伴非甲状腺疾病综合征中的应用[J]. 临床心血管病杂志,2012,28(7):549-552.
[13] KALOGEROPOULOS A P, TANG W H, HSU A, et al. High-sensitivity C-reactive protein in acute heart failure: insights from the ASCEND-HF trial[J]. J Card Fail,2014,20(5):319-326.
[14] 郭拥军,张登庆,葛艳.左西孟旦对慢性心力衰竭心室收缩同步性的影响[J]. 临床心血管病杂志,2013,29(4):254-256.
[15] 罗毅,刘路培,黄振宇,等.左西孟旦对急性心肌梗死并发心源性休克患者的疗效观察[J]. 实用医学杂志,2013,29(19):3229-3230.

急性心衰患者NTpro-BNP,cTnI,hs-CRP的变化及其临床意义

NTpro-BNP, CTnI and Hs-CRP changes of patients with acute heart failure and its clinical significance

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价