胃癌组织miR-9的表达及其与临床病理的关系

doi:10.3969/j.issn.1000-8535.2016.03.003

广州医药 ›› 2016, Vol. 47 ›› Issue (3): 8-10.DOI: 10.3969/j.issn.1000-8535.2016.03.003

胃癌组织miR-9的表达及其与临床病理的关系

余丹纯, 聂玉强, 贾林, 黄耀星, 孙小娟

广州市第一人民医院消化内科(广州 511457)

收稿日期:2015-02-15 出版日期:2016-05-20 发布日期:2021-11-30

The correlation between miR-9 expression and clinicopathology in gastric carcinoma

Yu Danchun, Nie Yuqiang, Jia Lin, et al

Department of Gastroenterology,Guangzhou First People's Hospital, Guangzhou 510180, China

Received:2015-02-15 Online:2016-05-20 Published:2021-11-30

摘要/Abstract

摘要： 目的观察miR-9在胃癌组织中的表达水平及其与临床病理的相关性。方法采用实时荧光定量PCR方法分别检测28例胃癌及正常胃组织中miR-9的表达水平,并分析其表达情况与临床病理资料的关系。结果胃癌组织miR-9的表达水平[0.0078(0.0031~0.0142)]显著低于相应正常胃组织[0.0177(0.0084~0.0311), P<0.05],尤其是伴淋巴结转移者[0.0021(0.0006～0.0685)]miR-9表达水平明显降低。结论胃癌组织中miR-9低表达,且与胃癌淋巴结转移有关。

关键词: 胃肿瘤, 临床病理学, 逆转录聚合酶链反应, miR-9

Abstract: Objective To investigate the correlation between the level of miR-9 expression and clinicopathology in gastric carcinoma. Methods The expression of miR-9 in 28 cases of gastric carcinoma tissues and normal gastric tissues were detected by quantitative real-time PCR, and the relationship between the expression and clinicopathology was analyzed. Results The expression of miR-9 expression in gastric carcinoma tissues [0.0078(0.0031~0.0142)] was significantly lower compared with the corresponding normal gastric tissues [0.0177(0.0084~0.0311), P<0.05], especially in lymph node-invasive carcinoma [0.0021(0.0006～0.0685)]. Conclusion miR-9 was down regulated in gastric cancer tissues, which was significantly associated with lymph node metastasis.

Key words: Gastric neoplasms, Clinicopathology, Reverse transcriptase polymerase chain reaction, miR-9

余丹纯, 聂玉强, 贾林, 黄耀星, 孙小娟. 胃癌组织miR-9的表达及其与临床病理的关系[J]. 广州医药, 2016, 47(3): 8-10.

Yu Danchun, Nie Yuqiang, Jia Lin, et al. The correlation between miR-9 expression and clinicopathology in gastric carcinoma[J]. Guangzhou Medical Journal, 2016, 47(3): 8-10.

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胃癌组织miR-9的表达及其与临床病理的关系

The correlation between miR-9 expression and clinicopathology in gastric carcinoma

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