逍遥散治疗首发抑郁症的疗效与5-羟色胺2A受体基因多态性的关联研究

doi:10.3969/j.issn.1000-8535.2016.01.029

广州医药 ›› 2016, Vol. 47 ›› Issue (1): 81-82.DOI: 10.3969/j.issn.1000-8535.2016.01.029

逍遥散治疗首发抑郁症的疗效与5-羟色胺2A受体基因多态性的关联研究

陈健华, 葛鑫宇, 黄俊东, 伍远菲, 朱志敏

广州市脑科医院中医科 (广州 510370)

收稿日期:2015-06-10 出版日期:2016-01-20 发布日期:2021-11-30
基金资助:
广州市中医药科技项目(20132A011019)

Association between the curative effect of Xiaoyao San in the treatment of first-episode depression and 5-HT2A Receptor Gene Polymorphisms

Chen Jianhua Ge Xinyu Huang Jundong, et al

Received:2015-06-10 Online:2016-01-20 Published:2021-11-30

摘要/Abstract

摘要： 目的探讨逍遥散治疗首发抑郁症的疗效与5-HT2A受体基因多态性的关联。方法采用病例对照研究方法,以120例首发抑郁症患者(研究组)和120例正常人(对照组)为研究对象,研究组予逍遥散治疗,疗程8周。于治疗前后采用汉密顿抑郁量表评定。采用高温连接酶检测反应法(LDR)检测5-HT2A受体基因,分析其与抗抑郁药物疗效的关系。结果 5-HT2A受体基因(T102C)T／C基因型、C／C基因型频率及等位基因频率与对照组相比差异无统计学意义(P﹥0.05)。不同基因型的疗效无差异(P﹥0.05)。结论 5-HT2A受体基因(T102C)多态性与逍遥散治疗抑郁症的疗效无关联。

陈健华, 葛鑫宇, 黄俊东, 伍远菲, 朱志敏. 逍遥散治疗首发抑郁症的疗效与5-羟色胺2A受体基因多态性的关联研究[J]. 广州医药, 2016, 47(1): 81-82.

Chen Jianhua Ge Xinyu Huang Jundong, et al. Association between the curative effect of Xiaoyao San in the treatment of first-episode depression and 5-HT2A Receptor Gene Polymorphisms[J]. Guangzhou Medical Journal, 2016, 47(1): 81-82.

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逍遥散治疗首发抑郁症的疗效与5-羟色胺2A受体基因多态性的关联研究

Association between the curative effect of Xiaoyao San in the treatment of first-episode depression and 5-HT2A Receptor Gene Polymorphisms

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