抑郁障碍患者血清IL-2和TNF-α水平与认知功能的相关性研究

doi:10.3969/j.issn.1000-8535.2015.04.019

广州医药 ›› 2015, Vol. 46 ›› Issue (4): 58-59.DOI: 10.3969/j.issn.1000-8535.2015.04.019

抑郁障碍患者血清IL-2和TNF-α水平与认知功能的相关性研究

古智文, 潘小平, 张璐璐, 徐利敏, 陈丽萍, 李雪蓉, 曾贤威, 谢韫诗, 梁国强

广州市第一人民医院精神心理科(广州 510180)

收稿日期:2015-01-23 发布日期:2021-11-30
通讯作者: 潘小平,E-mail:14481127@qq.com
基金资助:
广州市重大科技合作项目(2012J5100039)广州市科技计划项目(2012J4300086)

Associations between serum IL-2 and TNF-α level and cognitive function in the depression patients

Gu Zhiwen, Pan Xiaoping, Zhang Lulu, et al

Department of Psychiatry, Guangzhou First People's Hospital,Guangzhou 510180,China

Received:2015-01-23 Published:2021-11-30

摘要/Abstract

摘要： 目的检测抑郁障碍患者血清中IL-2和TNF-α水平,探讨IL-2和TNF-α水平与认知功能情况相关性。方法采用酶联免疫吸附法(ELISA)检测100例抑郁障碍患者(观察组)和100例健康人(对照组)的血清IL-2、TNF-α的水平,并结合汉密尔顿抑郁量表(HAMD)观察患者抑郁障碍的严重程度,应用Loewenstein 认知评定量表评定患者的认知状态情况进行相关分析。结果与对照组相比,观察组的IL-2、TNF-α的水平明显更高(P<0.05)。IL-2、TNF-α的水平与HAMD,LOTCA总分呈正相关(P<0.05)。结论抑郁障碍患者血清中IL-2、TNF-α的水平与抑郁障碍患者的严重程度和认知状态情况呈正相关。

关键词: 抑郁障碍, IL-2, TNF-α, 认知功能

Abstract: Objective To study the levels of serum IL-2 and TNF-α in depressed patients and theircorrelations with the cognitive function. Methods 100 depressed patients (observation group) and 100 healthy people (control group) were enrolled to this study and we compared their levels of serum IL-2 and TNF-α detected by enzyme-linked immunosorbent (ELISA) from two groups. The correlation analyses of the serum IL-2 and TNF-α levels with the severity of depression of depressed patients observed with Hamilton depression scale (HAMD), and the serum IL-2 and TNF-α levels with the cognitive function evaluated with Loewenstein were conducted. Results The levels of serum IL-2 and TNF-α in the observation group were significantly higher than control group (P<0.05).There were positive correlations between the levels of IL-2 and TNF-α and HAMD scores and between the levels of IL-2 and TNF-α and LOTCA scores (P<0.05). Conclusion The levels of serum IL-2 and TNF-α in the depressed patients were positively correlative with the severity of depression and their cognitive function.

Key words: Depression, IL-2, TNF-α, Cognitive function

古智文, 潘小平, 张璐璐, 徐利敏, 陈丽萍, 李雪蓉, 曾贤威, 谢韫诗, 梁国强. 抑郁障碍患者血清IL-2和TNF-α水平与认知功能的相关性研究[J]. 广州医药, 2015, 46(4): 58-59.

Gu Zhiwen, Pan Xiaoping, Zhang Lulu, et al. Associations between serum IL-2 and TNF-α level and cognitive function in the depression patients[J]. Guangzhou Medical Journal, 2015, 46(4): 58-59.

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抑郁障碍患者血清IL-2和TNF-α水平与认知功能的相关性研究

Associations between serum IL-2 and TNF-α level and cognitive function in the depression patients

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