血清降钙素原与中性粒细胞淋巴细胞比率对急性胰腺炎继发急性肺损伤的预测价值

doi:10.3969/j.issn.1000-8535.2015.03.017

广州医药 ›› 2015, Vol. 46 ›› Issue (3): 60-63.DOI: 10.3969/j.issn.1000-8535.2015.03.017

血清降钙素原与中性粒细胞淋巴细胞比率对急性胰腺炎继发急性肺损伤的预测价值

冯健华

南方医科大学第五附属医院内科(从化 510900)

收稿日期:2015-02-04 出版日期:2015-05-20 发布日期:2021-11-30
通讯作者: 冯健华,E-mail:13928728361@163.com
基金资助:
广州市科技计划项目(201300000196)

The value of serum procalcitonin levels and neutrophil-to-lymphocyte ratio (NLR) in predicting acute lung injury secondary to acute pancreatitis

Feng Jianhua

Department of Medicine,5^th Affiliated Hospital of Southern Medical University,Conghua 510900,China

Received:2015-02-04 Online:2015-05-20 Published:2021-11-30

摘要/Abstract

摘要： 目的探讨血清降钙素原(PCT)与中性粒细胞淋巴细胞比率(NLR)对预测急性胰腺炎(AP)继发急性肺损伤(ALI)的临床适用性。方法回顾性分析60个AP病例,对合并ALI的实验组和没有合并ALI的对照组治疗前后血清PCT和NLR进行均数比较、相关性分析、ROC分析等统计分析。结果两组间治疗前NLR(P=0.019)与治疗期间血清PCT平均值(P<0.001)有统计学差异,ROC分析:治疗前NLR、治疗期间血清PCT平均值对于预测ALI的灵敏度、特异度、约登指数分别为0.778、0.889;0.690、0.881;0.468、0.77,两者的差异有统计学意义(P=0.0134)。结论急性胰腺炎早期治疗前,NLR对于预测ALI有一定的参考价值,而在急性胰腺炎后期,治疗期间的血清PCT平均值对于预测ALI有着良好的灵敏度和特异度,具有一定的临床适用性。

关键词: 急性胰腺炎, 急性肺损伤, 降钙素原, 中性粒细胞淋巴细胞比率

Abstract: Objective To investigate the clinical applicability of serum procalcitonin levels and neutrophil-to-lymphocyte ratio (NLR) in predicting acute lung injury(ALI) secondary to acute pancreatitis(AP). Methods Sixty cases of AP were recruited to explore their serum-PCT and NLR before/after treatment. Means comparison, correlation analysis, ROC analysis were carried out. Results The NLR before treatment (P=0.019)and serum-PCT after treatment(P<0.001)were statistical significance of two groups(ALI、NON-ALI). In ROC analysis, the sensitivity, specificity, Jorden index of above two index were 0.778、0.889;0.690、0.881;0.468、0.77 respectively. There were statistically significant differences between them(P=0.0134). Conclusion In the early phase before treatment in AP, NLR has certain reference value in predicting ALI. On the other hand, in the later phase after treatment in AP, serum-PCT has great sensitivity, specificity and clinical applicability.

Key words: Acute pancreatitis, Acute lung injury, Procalcitonin, Neutrophil-to-lymphocyte ratio

冯健华. 血清降钙素原与中性粒细胞淋巴细胞比率对急性胰腺炎继发急性肺损伤的预测价值[J]. 广州医药, 2015, 46(3): 60-63.

Feng Jianhua. The value of serum procalcitonin levels and neutrophil-to-lymphocyte ratio (NLR) in predicting acute lung injury secondary to acute pancreatitis[J]. Guangzhou Medical Journal, 2015, 46(3): 60-63.

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血清降钙素原与中性粒细胞淋巴细胞比率对急性胰腺炎继发急性肺损伤的预测价值

The value of serum procalcitonin levels and neutrophil-to-lymphocyte ratio (NLR) in predicting acute lung injury secondary to acute pancreatitis

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