小剂量雄性激素联合左卡尼汀治疗特发性弱精子症的研究

doi:10.3969/j.issn.1000-8535.2015.01.006

广州医药 ›› 2015, Vol. 46 ›› Issue (1): 17-18.DOI: 10.3969/j.issn.1000-8535.2015.01.006

小剂量雄性激素联合左卡尼汀治疗特发性弱精子症的研究

郭顺添, 甄国志, 甄锦壮, 梅凤琦, 何正枝, 麦福劲

广东省佛山市顺德区妇幼保健院生殖中心(佛山 528300)

收稿日期:2014-11-19 发布日期:2021-11-30

Research of low dose androgen combined with levocarnitine on curing idiopathic asthenospermia

Guo Shuntian, Zhen Guozhi, Zhen Jinzhuang, et al

Reproductive Centre of Shunde Maternal and Child Health Hospital,Foshan 528300,China

Received:2014-11-19 Published:2021-11-30

摘要/Abstract

摘要： 目的观察十一酸睾酮联合左卡尼汀治疗特发性弱精症的疗效。方法回顾性分析2012年11月—2014年6月在我科诊断为弱精子症的386例患者的临床资料,按标准分成轻(A组)、中(B组)、重(C组)3组。分别给予左卡尼汀、十一酸睾酮联合左卡尼汀治疗,观察两种治疗方法对特发性弱精子症的疗效。结果 A组、B组患者两种治疗方法治疗后精子PR均有升高,差异有统计学意义(P＜0.05),C组患者给予左卡尼汀治疗患者治疗后PR无改善,差异无统计学意义(P＞0.05);十一酸睾酮联合左卡尼汀治疗患者治疗后PR升高,差异有统计学意义(P＜0.05)。A、B、C组患者给予左卡尼汀治疗的有效率分别是47.6%,41.7%,18.9%,总有效率为37.9%;A、B、C组患者给予十一酸睾酮联合左卡尼汀治疗的有效率分别是52.6%,45.5%,34.7%,总有效率为45.5%。A组、B组患者两种治疗方法疗效无差异(P＞0.05);C组患者给予十一酸睾酮联合左卡尼汀组有效率高于给予左卡尼汀组,差异有统计学意义(P＜0.05)。结论十一酸睾酮联合左卡尼汀治疗特发性弱精子症的疗效优于左卡尼汀单一用药。

关键词: 十一酸睾酮, 左卡尼汀, 特发性弱精子症

Abstract: Objective To observe the effects of eleven acid testosterone combined with L-carnitine on curing idiopathic asthenospermia. Methods Retrospective analysed the clinical data of 386 patients with asthenospermia patients from November 2012 to June 2014 in our department.According to the standard,the patients were divided into mild A,moderate B,severe C in 3 groups,given L-carnitine treatment and given eleven acid testosterone combined with L-carnitine treatment.We observed effect of the two therapeutic methods for the treatment of idiopathic asthenospermia. Results The sperm PR were increased,In group A and group B patients after treated.The difference was statistically significant(P<0.05).In group C,the patients received the treatment of L-carnitine,the sperm PR has no obvious improvement,There was no significant difference(P>0.05).The patients received the treatment of eleven acid testosterone combined with L-carnitine the sperm PR significantly increased,the difference was statistically significant(P<0.05).The treatment efficiency of A,B,C group received L-carnitine were 47.6%,41.7%,18.9%,the total effective rate was 37.9%.The treatment efficiency of A,B,C group received eleven acid testosterone combined with L-carnitine were 52.6%,45.5%,34.7%,the total effective rate was 45.5%;There was no significant difference in group A and group B(P>0.05).The treatment efficiency in group C received eleven acid testosterone combined with L-carnitine group is obviously higher than that given L-carnitine group,the difference was statistically significant(P<0.05). Conclusion The curative effect of eleven acid testosterone combined with L-carnitine in the treatment of idiopathic asthenospermia is better than that of L-carnitine single drug treatment.

Key words: Eleven acid testosterone, levocarnitine, Idiopathic asthenospermia

郭顺添, 甄国志, 甄锦壮, 梅凤琦, 何正枝, 麦福劲. 小剂量雄性激素联合左卡尼汀治疗特发性弱精子症的研究[J]. 广州医药, 2015, 46(1): 17-18.

Guo Shuntian, Zhen Guozhi, Zhen Jinzhuang, et al. Research of low dose androgen combined with levocarnitine on curing idiopathic asthenospermia[J]. Guangzhou Medical Journal, 2015, 46(1): 17-18.

小剂量雄性激素联合左卡尼汀治疗特发性弱精子症的研究

Research of low dose androgen combined with levocarnitine on curing idiopathic asthenospermia

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