表4 GSH敏感DOX前药及其体外释放特征
敏感键 | 考察时间 | 考察指标 | |
PEG-PCL-SS-DOX[36] | 二硫键 | 70 h | 0 mmol/L DTT 70% vs 50 mmol/L DTT 90% |
PP-SS-DOX[37] | 二硫键 | 100 h | PBS 80% vs PBS+DTT 100% |
DOX-SS-H[38] | 二硫键 | 25 h | 0 mmol/L DTT 0% vs 50 mmol/L DTT 38% |
DOX-SS-FOL[39] | 二硫键 | 3 h | PBS 0% vs PBS+GSH 100% |
DOX-SS-PTX[40] | 二硫键 | 120 h | PBS 40% vs PBS+GSH 90% |