前药名称

敏感键

考察时间

考察指标

HCCP-BM-DOX[14]

腙键

56 h

pH7.4 15.8% vs pH5.0 28.5%

DOXDT[15]

腙键

90 h

pH7.4 10% vs pH6.8 20% vs pH5.0 70%

mPPDPP-hyd-DOX[16]

腙键

50 h

pH7.4 10% vs pH6.5 20% vs pH5.0 60%

DOX-PhMV-PEG[17]

腙键

192 h

pH7.4 10% vs pH6.4 40% vs pH5.2 80%

DOX-hyd-TS[18]

腙键

50 h

pH7.4 20% vs pH6.8 40% vs pH5.0 85%